Акушерство и гинекология


Abramov M.A., Polonnikova A.A.


Resume. Since the appearance of the new coronavirus infection COVID-19, the question of the impact of the transmitted infection on the human body has become relevant. It is known that NCI is characterized by changes in the functioning of the hemostasis system with the development of adverse thromboembolic complications. Even more relevant is the question of the effect of the NCI on the course of pregnancy, childbirth and the postpartum period. The purpose of the study: to evaluate the features of the course of the postpartum period in women in labor who underwent NCI during pregnancy. Materials and methods. A retrospective analysis of the birth histories of patients who underwent NCI during pregnancy and delivered in the Clinic of Obstetrics and Gynecology of the Military Medical Academy named after S.M. Kirov in the period 2021-2022 was carried out. A total of 30 patients were included in the study, 15 of whom underwent NCI during pregnancy - the main group. The control group included patients with no indication of a transferred NCI.

The results of the study:

Total blood loss in the main group was 378.53±57.92 ml, in the control group 264.60±95 ml (p=0.04). According to ultrasound data immediately after delivery, the uterine body dimensions in the main group of maternity women were 152.00±24.00 mm, 88.00± 11.00 mm, 110.00±15.00 mm in the main group, in the control group - 107.50±33.00 mm(p=0.03), 75.00±18.00 mm(p=0.04), 97.00±19.00 mm(p=0.02). The width of the uterine cavity in the mothers of the main group was 31.00 ± 1.22 mm, in the control group - 8 ± 2.85 mm (p ≤0.5). At the same time, 72 hours after delivery, no statistically significant differences were found between the parameters of pelvic ultrasound in patients of both study groups.


Thus, it was found that in maternity women who underwent NCI during pregnancy in mild form, there is a statistically significant increase in the size of the body and the uterine cavity, as well as increased total blood loss, regardless of the parity of labor. At the same time, 72 hours after delivery, there were no changes detected immediately after delivery. Since there were no postpartum hemorrhages in these cases, it can be argued that the prophylactic administration of oxytocin solution is sufficient to compensate for the detected changes.

Молодежный инновационный вестник. 2023;12(S2):4-6
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Altunina A.I., Chernykh A.D.


This study was conducted to assess the condition of the fetus by automated CTG using computer calculations and analysis of indicators according to the Dawes/Redman criteria. Currently, cardiotographic monitoring is the "gold standard" of examination in obstetrics [1,2]. This method allows you to record changes in heart rate for monitoring and assessing the condition of the fetus, as well as a comprehensive examination of pregnant women and women in labor [3,4].
The study involved 75 primiparous and multiparous patients with various obstetric and extragenital pathologies. It should be noted that during the study, all 75 participants were under the supervision of women's clinic No. 1 of the Central District of Voronezh. On the basis of CCEH No. 10 (Voronezh), an automated mobile fetal monitor "ILIFIA" by USONTEC was used to assess the condition of the fetus by remote monitoring using computer calculations and analysis of CTG indicators according to Dawes / Redman criteria at 32-40 weeks of gestation .
The study also assessed the asphyxia of the newborn at the 1st and 5th minute after birth and compared the correspondence of the CTG findings to the results of the Apgar score.
All data collected from the results of a non-stress test and Apgar scores were analyzed using Spearman's rank correlation with the calculation of the mean error and the arithmetic mean. The sensitivity, specificity and accuracy of the automated mobile CTG method was determined.

Молодежный инновационный вестник. 2023;12(S2):6-7
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Buhtoyarova A.A., Markin D.A.


Relevance. The new coronavirus infection (NKI) significantly exacerbates pregnancy pathologies. Pregnant women with iron deficiency anemia (LDA) are more often admitted to infectious diseases hospitals with NKI (especially in the III trimester, when the inflammation processes are maximally activated). Purpose. To establish how often LDA becomes a predictor of NKI, how it affects the course of pregnancy, childbirth and the postpartum period. Materials and methods. To fulfill the purpose of the study, 133 maternity histories with laboratory-confirmed NKI were analyzed - the main group. The comparison group included 60 pregnant women with HDA only during pregnancy, without NKIs. Results. Studies have shown that pregnant women of the main group had HDD before pregnancy: in most cases, mild rather than severe. The course of pregnancy in women with BIA in 100% of cases complicated NKI in the III trimester: 90% - mild, 10% - moderate. In the comparison group, in 100% of the case in the III trimester of pregnancy, pregnant women were diagnosed with anemia: mild - 90%, moderate - 10%. Anemia in this group was always mild. Delivery of pregnant women with NKI and BIA in 11% of cases occurred during pregnancy from 30 to 36 weeks. There was no preterm birth in the comparison group. Caesarean delivery as a method of delivery was significantly more common in the comparison group. Pregnant women with NKIs gave birth through the natural birth route (62%) with fewer complications than women with pregnant anemia. In the main group, 134 newborns were born: 94% without asphyxia, 6% in asphyxia and 2% stillbirth. In the comparison group, all children (61 newborns) were born alive, full-term, the early neonatal period proceeded without complications. Conclusion. GDA also creates conditions for the formation of an immunodeficiency state, which increases the risk of infection with NKI. Pregnancy anemia, which occurred in the III trimester, corrected with iron drugs, did not affect the immune system of women and did not lead in any case to infection with SARS-CoV-2 strains.

Молодежный инновационный вестник. 2023;12(S2):10-12
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Gorushkina E.S., Kulikova E.V., Markin D.A.


Relevance. Achievements in research aimed at finding the etiological factor of malignant neoplasms make it possible to develop new preventive measures, create targeted therapy and reduce the mortality rate from this pathology. In Russia, one of the most common pathologies in women is cervical cancer. Pathology is associated with the carriage of the human papillomavirus, which creates the preconditions for early detection of infection and the organization of preventive measures to prevent its spread.

Purpose of the study: using a general morphological analysis, tachymetric and crystalloscopic research methods, to identify differences in the manifestation of the phenomenon of arborization during persistence in the body of the human papillomavirus.

Materials and methods: 100 native dried samples of cervical mucus were used for the study, 75 of which were taken from women with confirmed carriage of the human papillomavirus. Survey microscopy using a research microscope ZEISS Axio Imager.A2, processing of statistical data in the software packages STATISTICA (StatSoft Russia 4.0) and Microsoft Office Excel 2010.

Results. A change in the structure of the epithelium, especially in the area of the external cervical os, leads to a violation of its function. The cervical mucus secreted by these cells is a glycoprotein that changes its physicochemical properties depending on the concentration of estrogens. The discovery of new manifestations of the phenomenon of arborization in native dried samples of female carriers of the human papillomavirus will allow the development of a new accessible diagnostic technique.

Молодежный инновационный вестник. 2023;12(S2):12-14
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Amiraeva Z.N., Stakeeva C.A., Iskenderova A.K., Zholdoshbekova G.Z.


Despite the efforts that the country is making, maternal mortality in Kyrgyzstan remains at a high level, about 38.1 cases per 100,000 live births. Realizing that that confidential enquiry into maternal deaths (CEMD) is the international gold standard for a detailed investigation of the deaths of women, Kyrgyzstan has been implementing this methodology at the national level since 2010.

Aim is to study the influence of medical and non-medical risk factors on the maternal mortality rate in the Kyrgyz Republic.

Methods. To identify medical and non-medical causes of maternal mortality, factors of poor-quality treatment, as well as social and family problems that could affect the tragic outcome, the study group included all cases of deaths of women during pregnancy, childbirth and within 42 days of the postpartum period from direct and indirect causes. In addition, cases of deaths of women from causes unrelated to pregnancy were considered, which were classified as "Absence of an obstetric cause (accidents)", and the category "The main cause was not established", when information was insufficient to establish the cause of death of a woman.

Results. The CRMS method was used to analyze 148 cases of deaths of women during pregnancy, childbirth and the postpartum period in the Kyrgyz Republic in 2014-2015. The average age of the deceased women was 32.5 years and ranged from 17 to 48 years.

The increase in the frequency of operative delivery is observed all over the world, including in the Kyrgyz Republic.

Conclusion. Thus, the most vulnerable were women who did not have a permanent job over the age of 35, who were about to give birth for the first time. Caesarean section is a very high risk factor for maternal mortality in the Kyrgyz Republic, when the likelihood of obstetric bleeding and sepsis in the postpartum period increases.

Молодежный инновационный вестник. 2023;12(S2):8-10
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Dorokhova E.A.


Relevance. Currently, bacterial vaginosis is significantly common among women of childbearing age. Today, antibacterial therapy is used to treat BV, but the cure rate is low and the recurrence rate is high. Considering the similar physiological environments of the intestinal tract and the vaginal tract, as well as the pathogenesis of intestinal infection and vaginal infection, the possibility of transplantation of vaginal microbiota (VMT) and its potential use in BV by the type of intestinal (fecal) microbiota transplantation (FMT) for the treatment of intestinal infections is currently being investigated.
The purpose of the study. study and review of a new approach to the treatment of bacterial vaginosis – vaginal microbiota transplantation.
Materials and methods: analysis of foreign and domestic publications (including using databases) devoted to topical methods of treatment of bacterial vaginosis.
Results: Analysis of statistical data shows that TBI demonstrates better efficacy than the current traditional antibiotic treatment in the treatment of recurrent BV, and solves the associated disadvantages of antibiotic abuse, the appearance of drug-resistant bacteria and the high frequency of relapses caused by antibiotic treatment.
Conclusion: Compared with other methods of BV treatment, VMT, which mainly modulates the microbial environment of the vagina, can completely restore the female vaginal microbial environment to a healthy state for the treatment of BV and prevent its recurrence. Industrial production of TDC will reduce the burden on society and bring huge economic benefits.

Молодежный инновационный вестник. 2023;12(S2):14-16
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Dutova O.I.


The relevance: Gestational anemia is one of the most common problems that complicate the course of pregnancy and childbirth. Due to the high prevalence and the huge number of caused complications, anemia during pregnancy is one of the most pressing problems of modern obstetrics. Despite the increased attention of scientists to this condition, there is no tendency to decrease the frequency of occurrence at the moment.

Objective: to study the features of somatic and obstetric-gynecological anamnesis in patients with anemia during gestation.

Research methods: in the period from 01.12.2020 to 20.02.2021, the analysis of exchange cards, birth histories, and newborn histories was carried out in 57 patients delivered on the basis of the 2nd building of the VOKB№1 maternity hospital. We performed a statistical assessment of complications of somatic and obstetric-gynecological anamnesis, the course of pregnancy and childbirth, an anthropometric assessment and the incidence of complications in newborns. The main group consisted of 37 patients with gestational anemia, the control group consisted of 20 patients (without gestational anemia).

Results of the study: Patients with hemoglobin levels below 110 g/l in 89,3% had a complicated somatic history, which is 2 times higher than in the control group. Infertility, erosion, cervical dysplasia, STDs, abortions, and miscarriages were much more frequently diagnosed in the anamnesis. In the process of analyzing the course of pregnancy, placental abnormalities of varying severity, signs of intrauterine fetal hypoxia were most often diagnosed. Complications of childbirth in the main group were diagnosed 30% more often than in the control group.

Conclusion (заключение): The obtained results indicate the need for special vigilance to individuals with gestational anemia; early diagnostics and treatment of anemic conditions will significantly reduce obstetric and neonatal complications.

Молодежный инновационный вестник. 2023;12(S2):16-19
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Zholdoshbekova G.Z., Stakeeva C.A., Turgunbaeva Z.A.


An increase in the frequency of cesarean section above this level, according to WHO studies, on the contrary, increases the frequency of maternal complications and does not improve perinatal outcomes. Methods of termination of pregnancy in mothers with a scar on the uterus and antenatal fetal death in the second trimester of pregnancy continue to be debatable.

Aims. To evaluate the efficacy and safety of medical termination of pregnancy in patients with antepartum fetal death in the second trimester of pregnancy and a scar on the uterus after a previous cesarean section.

Material and methods. We observed 15 patients with antepartum fetal death at 27-28 weeks gestation and a scar on the uterus after cesarean section. The diagnosis of antepartum fetal death was established by the absence of fetal heartbeat during ultrasound examination performed immediately upon arrival of the pregnant woman in the hospital.

Results. The average interval between the start of stimulation (taking misoprostol) and the onset of labor was 6.6 ± 2.2 hours. The interval increased with increasing gestation period (p=0.0001) and was significantly higher in pregnant women who did not give birth vaginally (p=0.0001).

Conclusion. Medical termination of pregnancy in patients with a one scar on the uterus and antepartum fetal death in the second trimester should be carried out in all cases, provided there are no contraindications for vaginal delivery.


Молодежный инновационный вестник. 2023;12(S2):19-22
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Iskenderova A.K., Stakeeva C.A., Zholdoshbekova G.Z., Turgunbaeva Z.A.


Despite the relatively low prevalence, complications associated with Venous thromboembolism (VTE) lead, with a high degree of probability, to maternal mortality. Many deaths in women can be prevented by thromboprophylaxis in risk groups. However, the issues of identifying risk factors for the development of VTE during pregnancy, childbirth and the postpartum period continue to be debatable.

Aims. To study the risk factors for maternal mortality in pulmonary embolism (PE).

Material and methods. A retrospective analysis of primary medical documentation of 8 cases of maternal death from pulmonary embolism in the Kyrgyz Republic for 2014-2015 and 2018-2019 was carried out. To determine the relationship between risk factors for PE, a relative risk (RR) was calculated. The timing of the study was dictated by the fact that the analysis was conducted before the COVID-19 pandemic in the country.

Results. Pregnant women over 35 years of age are 7 times more likely to have PE than younger women. The risk of death after childbirth due to PE is significantly higher than the risk of death during pregnancy. In addition to the above, the parity of childbirth was also a significant risk factor for VTE. The relative risk of 3 in the group of women with obesity allows us to attribute the excess weight factor to the risk group for the development of PE. The risk of dying from PE after operative delivery was higher than after vaginal delivery, which allows us to consider caesarean section as a significant risk factor for VTE.

Conclusion: Failure to identify risk factors for VTE during pregnancy, childbirth and the postpartum period is a high-risk factor for maternal morbidity and mortality due to thrombosis, because prevention of VTE development is not carried out or delayed.

Молодежный инновационный вестник. 2023;12(S2):22-24
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Kalinina K.E., Markin D.A.


Relevance: In an unfavorable demographic situation, the birth of a healthy child becomes one of the urgent problems. Currently, women with a high level of responsibility for the health of the unborn child, who are practically healthy and do not require medical interventions, apply for pre-pregnancy training [3].

Objective: to analyze the importance of pre-gravidar training of women reproductive age. Materials and methods: analytical and statistical methods.

Results: As part of the research, 82 women of reproductive age were interviewed: 90.2% aged 18-35 years, 6.1% aged 36 to 45, and 3.7% were girls under 18 years old. The overwhelming majority of 73.2% of women are in a relationship, of which 32.2% are in a civil marriage. The majority of respondents 74.4% are sexually active and prefer the following methods of contraception: barrier (condom) – used by 42 women (51.2%) out of 82 respondents; natural (interrupted sexual intercourse, calendar

Молодежный инновационный вестник. 2023;12(S2):25-27
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Karpova D.V., Khoperskaya O.V.


Premenstrual syndrome is a set of mental and physical symptoms that occur in the luteal phase of the menstrual cycle and lead to a decrease in the quality of life, performance and productivity of women. The prevalence of premenstrual symptoms varies by ethnicity, age, and social group, but the overall prevalence of premenstrual syndrome is about 80%. The aim of the study was to evaluate the effectiveness of drospirenone-containing combined contraceptives in the treatment of premenstrual syndrome.
The study group consisted of women of the early and optimal reproductive period (18-35 years old) who applied for an appointment at the antenatal clinic of the VGKP No. 1. The inclusion criteria for the study were the presence of symptoms of premenstrual syndrome according to a specially designed questionnaire, as well as the woman's reproductive age. The study involved 43 women voluntarily.
Patients who had symptoms of premenstrual syndrome were prescribed a drug that contains 3 mg of drospirenone and 20 μg of ethinyl estradiol, which the women took on a 24/4 basis for 3 menstrual cycles. The study found that when taking hormonal contraceptives, the severity of symptoms decreased by an average of 46%. The study showed the high efficiency of drospirenone-containing contraceptive in the treatment of women with premenstrual syndrome.


Молодежный инновационный вестник. 2023;12(S2):27-29
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Kolomiets E.V.


Purpose: to study the indicators of rheovasography in pregnant women with excessive weight gain.

Materials and Methods: The course of singleton pregnancy in 88 women diagnosed with excessive body weight gain was analyzed. The volume of circulating fluid was determined using a modern non-invasive method - rheovasography, using a monitor complex of the cardio-respiratory system and tissue hydration KM-AR-01-"DIAMANT-R".
Results: Based on the results of rheovasography, all women were divided into two groups. The 1st group included pregnant women with diagnosed hypovolemia (40 people); real BCC values ​​were 4.0±0.41 l (with due BCC 4.25±0.37 l), deviation of BCC from BCCd was -0.25±0.2 l. Group 2 included pregnant women with diagnosed hypervolemia (48 people); real BCC values ​​were 4.42 ± 0.48 l (with proper BCC 4.0 ± 0.38 l), deviation of BCC from BCCd was 0.42 ± 0.27 l.
Conclusion: The parameters of rheovasography and the mechanism of development of volemic disorders in pregnant women with pathological weight gain were studied.
Молодежный инновационный вестник. 2023;12(S2):29-30
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Kulikova E.V.


Relevance. Currently, the most common method of delivery is caesarean section. The reasons for the increase in the frequency of caesarean section (CS) are an increase in the incidence of pregnant women, a complicated course of pregnancy, a deviation in the course of labor, and also an antenatally diagnosed pathology of the fetus. Over the past 30 years, the processes of adaptation of newborns born by CS have been actively studied by scientists around the world. In this regard, it is interesting to analyze the issue of changes in the adaptive reactions of newborns born surgically. 
The purpose of the study: to analyze and review foreign and Russian-language literature on Relevance. Currently, the most common method of delivery is caesarean section. The reasons for the increase in surgical intervention for cesarean section (CS) are an increase in the incidence of pregnant women, a complicated course of pregnancy, a deviation in the course of childbirth, as well as antenatally diagnosed fetal pathology. Over the past 30 years, operative methods of delivery, and key factors influencing the processes of adaptation of newborns, have been actively studied. In this regard, it is interesting to analyze the issue of changes in adaptive reactions in such newborns. [1]
The purpose of the study: to analyze and review foreign and Russian-language literature on the topic of adaptation of newborns born surgically.
Materials and methods: We analyzed scientific publications on the topic of the impact of the CS on the adaptation of newborns, followed by combining information from various sources.
Results. As a result of the study, complications were considered, which in the vast majority of cases develop in children after cesarean section. Adaptation to environmental factors in these newborns is less favorable and can be manifested by: respiratory disorders, non-rhythmic movements of the chest during breathing, disorders of the cardiovascular activity, a high frequency of dysbiosis of any localization, the development of purulent-inflammatory pathologies, dental status disorders. Such functional disorders on the part of various body systems in the neonatal period indicate the need to single out children in a special risk group.
Conclusion. At this stage, it has been established that the choice of operative delivery has a diverse impact on the processes of adaptation of newborns. It is necessary to continue studying this problem in the future. Properly approach the choice of caesarean section, assess all the risks and long-term consequences. In this regard, performing a caesarean section at the request of a woman without a medical indication is unacceptable.

Молодежный инновационный вестник. 2023;12(S2):31-33
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Morozova A.V., Altukhova O.B., Kukhlii V.Y., Khludeeva N.D.


BACKGROUND. Urinary tract infection (UTI) is a common complication of pregnancy.   The incidence of IMP has increased from 1.6 to 15 per cent over the past 10 years, contributing to a significant increase in perinatal morbidity and mortality.

OBJECTIVE: To identify the dependency of aggravated obstetric history on pregnant women with urinary tract infections.

MATERIALS AND METHODS: As intended, a retrospective analysis was made of the birth records of 25 patients whose pregnancies were complicated by the IMP, which formed the core group. The Monitoring Group consists of 30 patients with mild somatic and obstetric history classified as practically healthy. The statistical processing of the material was carried out using the computer program "Excel". In the statistical processing of the results obtained, the main methods of statistical analysis for biological and medical research were used.

CONCLUSION. A retrospective study showed that urinary tract infection contributed to obstetric pathology. The data obtained from women in the primary and control groups show a significant difference in delivery and complications due to urinary tract infection. For this reason, pregnant women with IMP must be at high risk for obstetric complications, which requires more intensive drug interventions involving related professionals for early diagnosis, treatment and prevention.

RESULTS. By bacteriological method studies have identified the main causative agents of urinary tract infections, among which dominated by Escherichia coli; Enterococcus faecalis , Ureaplasma urealyticum. A number of complications occurring in pregnant women with asymptomatic bacteriuria, pyelonephritis, cystitis, including premature amniotic fluid discharge, preterm birth, compensated placental disorders. Are found fetal complications: fetal distress, low weight for gestational age fetus.

Молодежный инновационный вестник. 2023;12(S2):33-35
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Obernikhin K.I., Ivanov V.S.


Relevance. The development of medical digital technologies is proceeding in a number of areas: prevention, determination of diagnostic parameters, monitoring the course and effectiveness of treatment, consulting support and patient support. Mobile healthcare (mHealth) is a new direction in the IT field, focused on both the doctor and the patient. Digitalization, the transition to electronic document management, the development of telemedicine are the key tasks of the national project "Healthcare".
Purpose of the study. Develop a mobile application that allows you to evaluate the nature of the menstrual cycle both as part of the dynamic monitoring of the attached population, and in the case of the selection of HRT.
Materials and methods: object-oriented programming in the integrated Java IDE environment, current clinical protocols of the Russian Society of Obstetricians and Gynecologists (ROAG)
Results: a mobile application "AMK-Stop" was developed, which allows a woman to independently assess the nature of menstruation, and the attending obstetrician-gynecologist to dynamically monitor the patient's health status.
Conclusion: the introduction of mobile applications in the work of the outpatient service, in particular the antenatal clinic, will significantly improve the availability and quality of medical care, significantly reduce the financial costs of medical institutions for unreasonable calls. The predominant use of software components that do not require access to the Internet allows the population of remote areas to receive reliable and up-to-date information about their health that complies with all current clinical recommendations.

Молодежный инновационный вестник. 2023;12(S2):36-37
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Oboimova A.A.


Relevance: Anemia is a fairly common phenomenon during pregnancy, in connection with this, the definition of an anemic state is of particular relevance, especially in women whose delivery is carried out by caesarean section [1,2]. Blood loss during childbirth is an integral part of them, it is the background for the development of complications. The question of the accuracy of calculating blood loss is also relevant, since the amount of blood lost during surgery determines the subsequent treatment and rehabilitation of patients.



Target. To study the prevalence of anemic syndrome in pregnant women and puerperas delivered by caesarean section.

Material and methods of research: in the period from 12/16/2022 to 12/30/2022, an analysis of exchange cards, birth histories, newborn histories was carried out in 20 patients delivered by caesarean section in departments of the 2nd building of the Perinatal Center in Voronezh. A statistical assessment of the hemoglobin level was made at the first and last visit to the antenatal clinic, before the caesarean section, 3-5 days after the surgery and at discharge from the hospital. The level of hematocrit, ferritin, blood loss during the operation, data on the condition of newborns and the health of the mother were also assessed.

Results of the study. Anemia of varying degrees is detected in 60% of patients at different stages of the examination. Most often, a decrease in hemoglobin level occurred in women over 30 years old, with a complicated medical history, and also 3 times more often after a cesarean section and in the postpartum period.

Conclusion: The results obtained indicate the need for more careful laboratory monitoring of hemoglobin levels in preparation for pregnancy, during pregnancy and after delivery.

Молодежный инновационный вестник. 2023;12(S2):37-39
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Pozhidaeva V.V.




The annual increase in the number of cases of cervical cancer (CC) shows the urgent need to activate diagnostic and preventive measures among women of different age groups. The morphogenesis of CC has not been fully studied, the ideas about the oncomorphogenesis of CC are based on the assumption of the sequence of changes in the squamous epithelium from dysplasia to cancer.

Research objective

To study the clinical and morphological features of dysplasia and CC in women in different age groups.

Materials and methods

Surgical and biopsy material, conclusions of pathologists in patients with dysplasia and CC according to the data of the Voronezh Regional Pathology Bureau for the period 2017-2022. The analysis of the annual occurrence, age groups, categories of disease stages, the structure of the final diagnoses and localization of the malignant process, as well as the area and depth of the lesion was carried out.


The incidence of dysplastic changes (LSIL and HSIL) in the cervix had similar dynamics, most often observed in the age group of 30-39 years. CC in the vast majority of cases (97.2%) was represented by squamous cell carcinoma. The most frequent occurrence of CC was in the age group of 40-49 years, while maintaining a high occurrence in older age groups.


СС is represented by squamous cell carcinoma in 97.2% of cases. Among the dysplastic changes, HSIL (CIN2 and CIN3) significantly prevailed over LSIL (CIN1). The area of the lesion, the depth of invasion in СС in different age groups has no clinical and morphological regularity, which indicates the nonlinearity of cancer development in СС.

Молодежный инновационный вестник. 2023;12(S2):39-40
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Samoilova Y.S., Reutskaya V.V.


Background. One of the factors affecting the normal course and outcome of pregnancy is the good quality of sleep in the mother. During it, the woman's brain concentrates on analyzing information about the current physical state of the body in order to correct the altered parameters of homeostasis and the subsequent development of various action programs, which plays a key role throughout the entire gestational period. But according to research, with increasing pregnancy, women often have sleep disorders, daytime sleepiness, and anxiety-depressive disorders. Unfortunately, despite the high prevalence of the described conditions, routine assessment of sleep quality in patients is usually not performed. 

Objective: to study the prevalence of sleep apnea, anxiety and depressive disorders, the severity of daytime sleepiness and the quality of sleep in pregnant women in the third trimester.

Materials and methods. A screening study of sleep apnea, daytime sleepiness, sleep quality, anxiety and depressive disorders involved 44 pregnant women at 27-41 weeks of gestation. A number of tests were used: the Berlin questionnaire, the Epwort Sleepiness Scale, the Pittsburgh Sleep Quality Index. The Hospital Anxiety and Depression Scale was also used to identify and quantify the severity of symptoms of anxiety and depression.

Results. According to the results of the Berlin questionnaire, half of the women surveyed (22 out of 44) have a high risk of developing sleep apnea, according to the Pittsburgh Sleep Quality Index, 32 patients report poor sleep quality. According to the Epwort Sleepiness Scale , more than half of pregnant women reported the presence of daytime sleepiness of varying severity: mild (18 out of 23), moderate (4 out of 23) and severe (1 out of 23). Assessment of the psychological state showed various anxiety and depressive disorders also in half of the respondents (22 out of 44).

Conclusion. The results obtained show the need to include active screening in the algorithm for examining pregnant women. 

Молодежный инновационный вестник. 2023;12(S2):41-44
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Sidelnikov K.I., Suzdalkina V.M.


Uterine fibrοids are οne οf the mοst cοmmοn gynecοlοgical diseases, it is a benign neοplasm cοnsisting οf cells οf the smοοth muscles οf the uterus. It is fοund in a significant percentage οf wοmen, this is 25-30% οf the age grοup frοm 35 years, causing a significant deteriοratiοn in the quality οf life, reprοductive functiοn and is manifested by the fοllοwing clinical signs: the οccurrence οf frequent pulling pains with lοcalizatiοn in the lοwer abdοmen and lumbar regiοn, dysfunctiοnal bleeding οf the uterus, οvaries, changes and dysfunctiοn οf neighbοring οrgans (fοr example, dysuric disοrders οr chrοnic cοnstipatiοn). Risk factοrs fοr the οccurrence οf the disease include: chrοnic anοvulatοry cycle, οverweight and οbesity, frequent curettage and abοrtiοns, hereditary predispοsitiοn. In wοmen in the age range frοm 36 tο 45 years, in mοst cases, an interstitial-subserοus fοrm οf uterine fibrοids is detected. This fοrm manifests itself in the fοrm οf uterine bleeding, cοntributes tο the develοpment οf infertility, the οccurrence οf hyperplasia οf the endοmetrial layer and small-cystic οvarian changes, and it is alsο pοssible tο develοp diseases οf the mammary glands, which are directly related tο dishοrmοnal disοrders in a wοman's bοdy. 

The prοcess οf treating uterine fibrοids is carried οut by prescribing the drug "Mifepristοne", which, accοrding tο the classificatiοn, is included in the grοup οf synthetic sterοid agents with anti-prοgestοgenic activity, that is, it perfοrms a blοck at the stage οf expοsure tο hοrmοne receptοrs. At the same time, the fοllοwing results were οbtained: in mοst patients οf reprοductive age, a benign tumοr decreases by 50% already when chοοsing an initial dοse οf 25 mg / day. 

Молодежный инновационный вестник. 2023;12(S2):44-46
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Slavova A.O.


Relevance. Pregnancy is a time of significant changes occurring in the composition of the female body in order to support the growth and development of the fetus. Bioelectric impedance analysis (BIA) is used to assess body composition and hydration status. This method is a non-invasive, reliable and fast clinical approach that is well tolerated by patients. Segmental impedance measurement can be useful in pregnant women, especially in late pregnancy.

Purpose. To present an overview of various BIO applications in pregnant women.

Materials and methods. The review of relevant domestic and foreign scientific sources, a number of articles of Pubmed, Nature databases published over the past 10 years on the issue under study is carried out.

Results. According to the given search, 110 articles and clinical reviews devoted to the problem under study were found. The BIA method is successfully used to study the effect of excessive weight gain during pregnancy on the development of obstetric complications, such as gestational hypertension, preeclampsia.

Discussion. Studying the composition of the mother's body and correlating it with her energy balance could contribute to the development of nutrition recommendations for women. Body composition assessment can provide important directions for the diagnosis of gestational hypertension, preeclampsia in pregnant women.

Conclusions. Body composition assessment helps to better understand the importance of maintaining an appropriate body weight during pregnancy, which, in turn, will help reduce the incidence of diseases in women and their children. BIA is also used as one of the additional tests in assessing the risk of developing gestational hypertension and preeclampsia.

Молодежный инновационный вестник. 2023;12(S2):47-49
pages 47-49 views


Tarasov I.E.


Introduction. The World Health Organization (WHO) is concerned about the growing trend of obesity among the female population of reproductive age. Regarding pregnancy, obesity is a prognostically unfavorable risk factor for the development of preeclampsia, gestational diabetes mellitus with fetal macrosomia.
Goal. To conduct a comparative analysis of anthropometric data, eating behavior and motor activity of pregnant women with obesity.
Materials and methods. analysis of 148 individual cards of pregnant women and women in labor who were registered on an outpatient basis in the women's consultation of the BUZ IN "VGKP No. 1" in the period from 2020 to 2022. 2 comparison groups were formed: the main group – women with abdominal obesity diagnosed before pregnancy (n=114), the cotntrol group – with normal BMI (n=34). When registering, studies were conducted: BMI (height, weight), anthropometry (waist and hip circumference), DEBQ eating behavior assessment questionnaire, IPAQ motor activity questionnaire.
Results. the average age of women in the main group was 28.9±0.6 years, in the control group – 23.4± 1.2 years. A detailed analysis of the distribution of the incidence of obesity among pregnant women shows that a high percentage of cases (54%) occur in the age range of 20-29 years, and the smallest – up to 20 and over 40 years. Burdened heredity for violation of fat and carbohydrate metabolism was more often registered in the study group (86% of cases), against 15% of the control group. The average BMI in pregnant women of the main group was 38.9± 2.3 kg/m2, in the control group – 23.4± 0.5 kg/m2. A comparative analysis of anthropometric indicators shows that in the study group the coefficient of OT/O was 0.95±0.014, in the control group – 0.81±0.034. Body weight gain during pregnancy was statistically higher in the study group - 6.5 [2.8;10.2], while in the control group – 5.1 [3.3;6.8]. Conducting a questionnaire aimed at assessing eating behavior and physical activity demonstrates the predominance of indicators of eating disorders (irrational, irregular, excessive), low physical activity in the observation group, while in the control group 96% adherents of an active lifestyle and a rational and balanced diet.
Conclusions. The high incidence of eating disorders, motor regime, fat and carbohydrate metabolism among pregnant women leave the problem of obesity relevant and attracting close attention from the medical community. Lifestyle modification at the stage of pre–pregnancy preparation is a vector for reducing obstetric complications during pregnancy and childbirth.

Молодежный инновационный вестник. 2023;12(S2):49-50
pages 49-50 views


Ushenina E.M., Sapronova A.N., Lisitsa E.V.


Relevance. The problem of birth injuries (RT) of a newborn in the modern world is increasingly attracting the attention of doctors of various specialties due to the presence of an opinion about the obvious or apparent possibility of managing this perinatal pathology.
The purpose of the study is to identify possible risk factors that affect the formation of a birth injury to the fetus.
Materials and methods. 190 observations were analyzed, including 95 cases of birth trauma of a newborn in Omsk (main group) over the past 10 years. For the comparison group, a sample was made of 95 histories of normal childbirth histories.
Results. Obstetric complications contribute to the appearance of fetal injuries during childbirth (prematurity - 15.2%, overmaturity - 7.6%, feto-placental disorders - 20.9%), somatic diseases (20.9%), intrauterine infections (34, 2%). When assessing the course of the birth act, the following risk factors for RT were noted: premature outflow of water (37.5%), a long anhydrous period (16.2%), anomalies of labor forces. Problems in the formation of the placenta and umbilical cord were detected in 30.4% of cases of birth of children with RT (premature exfoliation of the placenta - in 14.3%, entanglement of the umbilical cord of the fetus - 6.7%).
Conclusion. Risk factors that damage the fetus during childbirth are obstetric complications (prematurity, postmaturity, fetoplacental insufficiency, incorrect insertion of the fetal head, macrosomia, narrow pelvis), somatic diseases, defective development of the placenta and umbilical cord, intrauterine infections, complications of childbirth.

Молодежный инновационный вестник. 2023;12(S2):51-53
pages 51-53 views

Медицинская биология


Korobova J.R.


RELEVANCE. The pathogenetic role of extracellular DNA in cardiovascular pathology, in particular hypertension, is not well understood, but its determination is widely used as a promising nonspecific marker of cytolytic processes in predicting the development of complications and mortality in trauma, bronchopulmonary diseases, and lung cancer.

TARGET. The aim of the work was to study the content of free-circulating DNA (scDNA) in the blood plasma of patients with hypertension as a possible biomarker of this pathology.

MATERIALS AND METHODS. The study involved 40 people, of which 20 are conditionally healthy and 20 patients with GB. Detection of ssDNA was carried out using the "diaGene kit for DNA isolation from blood plasma." The resulting DNA samples were used for chromatographic and spectrophotometric analysis.

RESULTS. In the course of the study, it was found that in patients with HD, the content of ss-DNA in the blood is significantly higher than in apparently healthy people. When conducting spectrophotometric analysis, an increase in optical density was also revealed in isolated samples from patients with GB compared with practically healthy individuals.

CONCLUSION. Based on the above, this indicator can presumably be a diagnostically and prognostically significant biomarker of hypertension.

Молодежный инновационный вестник. 2023;12(S2):54-55
pages 54-55 views

Биохимия и клинико-лабораторная диагностика


Zhaglin D.A., Rychenkova O.O., Starikova M.S.



Rheumatoid arthritis (RA) is a widespread polyetiological connective tissue disease that occurs in people of almost all age categories and leads to early disability due to damage to peripheral joints and internal organ systems. The search for drugs that reduce the severity of the disease is currently an urgent problem.

Purpose of the study

 Measurement of superoxide dismutase (SOD) enzyme activity in rat tissues in model RA and under the influence of mitochondria-targeted antioxidant (AO) SkQ1.

Materials and methods

 The study groups are represented by male laboratory rats. SOD activity was measured spectrophotometrically.


 Reactive oxygen species (ROS), the formation of which seems to be characteristic of the pathogenesis of the disease, have a significant effect on the state of the antioxidant system (AOS). It has been established that RA induction is associated with an increase in SOD activity in rat tissues, which may be associated with the activation of the AOS enzymatic link, which has an adaptive character - as a response to increased ROS generation. The introduction of targeted AO SkQ1 at various doses was accompanied by a decrease in SOD activity and their shift towards normal values in all tissues studied. The antioxidant activity of the drug is achieved due to the presence of plastoquinone in the SkQ1 molecule, which is capable of neutralizing ROS, as well as a lipophilic cationic group, which ensures immediate penetration of the compound directly into the mitochondrial matrix.


 The ability of SkQ1 to reduce the severity of oxidative stress (OS) that accompanies the course of RA can lead to a decrease in the load on AOS, which makes the use of the drug in the treatment of RA potentially promising.

Молодежный инновационный вестник. 2023;12(S2):56-58
pages 56-58 views


Rychenkova O.O., Starikova M.S., Zhaglin D.A.


Relevance. High levels of rheumatoid factors (RF) are one of the most significant signals of abnormal immune responses in the body. Since their discovery, RFs have been the subject of extensive studies because of their association with the development of rheumatoid arthritis (RA). Oxidative stress (OS) plays an important role in the pathogenesis of RA, contributing to the initiation and maintenance of local and systemic inflammation in RA. OS is thought to have effects on T-cell function and proliferation. An abnormal immune response involving T cells contributes to an increase in RF concentration. In this regard, it seems promising to use antioxidants in the treatment of the disease.

Objective. The objective of this study was to study the effect of an antioxidant compound, the mitochondrial protector SkQ1 (10-(6' plastoquinonyl)decyltriphenylphosphonium bromide), on the RF level in the blood serum of rats.

Materials and methods. A study was made of changes in RF parameters by the turbidimetric method in the blood serum of rats under experimental RA and exposure to SkQ1 against the background of the development of pathology.

Results. Administration of the drug at doses of 1250 and 650 nmol/kg to RA model rats led to a decrease in RF levels of IgA, IgM, and IgG classes.

Conclusions. The data obtained indicate the ability of the test compound to shift RF parameters towards control values under conditions of RA development due to the antioxidant activity of the SkQ1 molecule.

Молодежный инновационный вестник. 2023;12(S2):58-60
pages 58-60 views


Sekretareva U.S., Kotova A.O.


Relevance. The study of the influence of different temperatures on the structure of protein molecules is important for understanding the mechanism of changes in protein functions, determining the critical denaturation temperature, finds application in solving a number of practical problems, including in medicine. Thus, thermal denaturation can be used to remove proteins from various biological fluids, for example, blood plasma, which facilitates the processes of isolation and analysis of substances. Precipitation of proteins due to denaturation is used to determine their amount in the biomaterial [1].
Goal. The aim of our work was to study the effect of temperature on the protein structure, structural modifications of the protein globule were judged by the spectral properties and hydrodynamic radius of the native and thermomodified protein molecule.
Materials and methods. Bovine serum albumin (BSA) was selected as a model protein, which was heated in a thermostat for 15 minutes to the appropriate temperature (37, 45, 55 and 60 ° C)
Results. We studied the absorption spectra of solutions of native and thermomodified BSA, determined the contribution of light scattering to the absorption spectra of protein solutions. The hydrodynamic radius of the protein globule was studied by the method of dynamic light scattering.
The change in the protein structure is reflected in the change in the absorption spectrum of this solution. During thermomodification of BSA solutions, the optical density of the studied solutions increases. We calculated the contribution of light scattering to the growth of optical density. It is shown that the parameters characterizing light scattering increase with an increase in the BSA heating temperature.
Using the method of dynamic light scattering, it is shown that the radius of the native BSA globule is 3 nm, with an increase in temperature, the size of protein molecules increases.
Conclusion. With the help of spectral methods, it is possible to determine the denaturation of protein molecules, as well as the reversibility of these processes.

Молодежный инновационный вестник. 2023;12(S2):60-62
pages 60-62 views

Влияние факторов внешней среды на здоровье человека

The influence of nutrition on the health of medical university students in different periods of study

Akulova M.S.


Nutrition is one of the factors that has a significant impact on human health. The state of health of students during their studies decreases. And as you know, during the session it takes a lot of effort to safely close the exams, therefore, many students are in a state of pre-illness. This article presents the results of studies conducted to assess the nutrition of students, as a fundamental factor of health, in different periods of study (before and during the session). The aim of the study was to evaluate the nutrition of students taking into account the intensity of training at a medical university before and during the session. As research materials, a questionnaire method and an individual nutrition diary filled in by students throughout the day were used. The analysis of the results obtained was carried out, recommendations were made in order to adjust nutrition to improve health. As a result of the conducted research, it was revealed that the majority of students do not observe the rules of rational nutrition during the academic semester, and this situation worsens during the exams. The nutrition of students has a number of disadvantages, which include non-compliance with the daily diet, the ratio of proteins, fats, carbohydrates. At the same time, most students understand their mistake when building a diet, but do not take measures to eliminate them.

Молодежный инновационный вестник. 2023;12(S2):63-65
pages 63-65 views


Belikova A.M.


Relevance: Breast cancer (breast cancer) in the global structure of malignant neoplasms in women ranks 1st in morbidity and mortality. In 2020, more than 2.2 million cases of breast cancer were registered worldwide and about 685,000 women died from this disease. Today, breast cancer prevention plays a key role in the fight against the disease. Increasing women's awareness of breast cancer, changing their behavior, regular diagnostic examinations can significantly affect the reduction of the incidence of this disease.

Objective: To analyze the data on the incidence of the female population of breast cancer in the territory of the Russian Federation for the period from 2010 to 2020.

Methods: Retrospective epidemiological analysis of the morbidity of the population of the Russian Federation of breast cancer over a 10-year period.

Result: As a result of a retrospective epidemiological analysis, it was noted that the incidence of breast cancer in the population of the Russian Federation is registered annually throughout the analyzed period.In the dynamics of morbidity, there is a persistent tendency to an increase in morbidity with a high approximation coefficient (R = 1, an increase of 14.48 per 100 thousand population).

In the structure of the identified stages of breast cancer disease, the share of newly identified cases of the initial stage of the disease (1-2) accounts for the largest proportion (69%), and to a lesser extent (22% and 9%) – at stages 3 and 4, respectively.In the dynamics of each stage of breast cancer incidence in the population of the Russian Federation, there is a slight tendency to increase the detection of breast cancer at stages 1-2 of the disease and a tendency to decrease the detection of patients with stage 3 and even less often with stage 4 of the disease.

During the first year after the diagnosis of breast cancer, a fatal outcome is registered in 6.9% of patients, there is a tendency to decrease in indicators by 2020.

Conclusion: The dynamics of the incidence of breast cancer in the Russian Federation over the analyzed period has a persistent tendency to increase with a high approximation coefficient (R = 1). Diagnosis of breast cancer disease reveals this disease in patients at the early stages (1-2 stages) – 69%, in other cases, the diagnosis is made already at the late 3-4 stages (31%). The established fact of timely detection of the disease in the early stages can contribute to the timely initiation of therapy, which is the prevention of delayed treatment and cases of death

Молодежный инновационный вестник. 2023;12(S2):65-67
pages 65-67 views


Bervinova E.O.


Relevance: The high incidence of respiratory infections, the lack of availability of etiotropic treatment and means of specific prevention, contributed to the widespread use in medical practice of various groups of antimicrobial drugs, including antiviral and antibacterial.
Objective: The aim of the work was to study the frequency and structure of the use of antimicrobials in respiratory infections before and during the SARS-CoV-2 pandemic among young people aged 18-25.
Materials and methods: A descriptive cross-sectional study was conducted using a questionnaire on a specially designed questionnaire in Google form among the population of Voronezh. Statistical processing of the results was carried out using Microsoft Office Exel 2016 and STATTECH, the results were considered significant at p<0.05.
Results: The study found that with respiratory infections rarely, no more than once a year, more than 70% of young people took antiviral drugs, more than half - antibacterial drugs, significantly more often used antiviral agents. In the pre-pandemic period, antimicrobials were rarely used more often, no more than 1 time per year (p<0.001 compared with the use of 2 or more times per year). The frequency of antimicrobial use during the pandemic has not changed significantly. Changes took place in the structure of prescribing in relation to the use of antiviral drugs, which began to be taken 2 or more times a year 1.5 times more often compared to the pre-pandemic period, respectively, 48.44% versus 35.18%. Antimicrobials were significantly more often prescribed by medical professionals, significantly less often young people used the advice of relatives and acquaintances; 35.29% and 11.86% of respondents independently prescribed antiviral and antibacterial drugs, respectively.
Conclusion: The widespread use of antimicrobials in respiratory infections requires increased attention and monitoring due to the threatening growth of resistance of microorganisms.

Молодежный инновационный вестник. 2023;12(S2):68-70
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Bulgakova M.M., Pobezhimova M.A.


Relevance: The Covid-19 pandemic, with each new wave, has had a significant impact on humanity and has become a serious test for every region of our planet. The territory of the Russian Federation was covered by 5 waves of a new coronavirus infection, the main peaks of which were recorded in the autumn-winter and summer periods, mainly in the form of SARS. The clinical manifestations of a new coronavirus infection are diverse and do not depend on gender and age.

Purpose: Assess the main symptoms of a new coronavirus infection.

Methods: general scientific, hygienic, epidemiological, sociological using questionnaires.

Results: According to the results of the study, it was found that 226,004 cases of COVID-19 were recorded in the Voronezh region. The incidence was recorded throughout the year with peaks in July and from August to November. The highest growth rate was noted in June (158.69%), the largest decline in December (-67.96%). The incidence among the adult population for the analyzed period is 10746.03 per 100 thousand, among children - 1755.24 per 100 thousand of the population. A new coronavirus infection prevailed in people aged 18-44 years and children aged 7-14 years. The largest proportion of cases was registered among female representatives. It was found that the course of a new coronavirus infection prevailed in the form of SARS. Among different age groups, the course of the disease with symptoms of SARS and a laboratory-confirmed case of COVID-19 without clinical manifestations decreased with age, while the diagnosis of pneumonia, on the contrary, increased.

Conclusion: According to the data received, the new coronavirus infection is prone to uneven fluctuations with peaks in July and from August to November (839.06; 978.81; 1515.41; 2514.70 and 1056.56 per 100 thousand population). Among the sick, the adult population prevailed (93.4%), predominantly female (61.08%). It was noted that in 90.95%, regardless of gender, COVID-19 most often proceeded in the form of acute respiratory viral infections, with age the number of people diagnosed with pneumonia increased.

Молодежный инновационный вестник. 2023;12(S2):71-73
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Bulgakova M.M., Pobezhimova M.A.


Relevance: The human body has its own biological clock. These biological clocks are otherwise called the biorhythms of the body, they have a certain effect on the energy and activity of biological processes in organs and organ systems.

Rhythms can be divided into two types: physiological (rhythms that coincide with natural processes) and biological - they are responsible for simple reactions within the cell and behavioral features.

The most important are circadian rhythms, in which body changes are detected within one day. Thus, the biological clock is responsible for the daily normal functioning of a person. Violations often lead to a decrease in immunity, dysfunction of the endocrine glands, an increased risk of developing cardiovascular pathologies and obesity.

Purpose: to compare the effect of circadian rhythms on well-being, activity and mood among schoolchildren and students studying at a medical university.

Methods: a sociological method using the Horn-Ostberg technique and the SAN test (well-being, activity, mood), as well as statistical processing of the results.

Results: Most of the study participants, despite age periodization, are arrhythmics. The manifestations of circadian rhythm disorders in most of the respondents are manifested in the form of a decline in the level of working capacity (38% of respondents) and fatigue and nervous tension (19% of respondents). The influence of the chronotype on the mood of activity and well-being in primary school students has not been reliably confirmed, and in the case of students of 5-6 courses, the correlation indicators between mood in the morning and evening hours and the corresponding chronotype "lark" or "owl" are already more significant r= 0.74 and r=0.71 at p<0.05. Based on the data obtained, an approach was developed for the prevention of circadian rhythm disorders.

Conclusion: Thus, the majority of study participants are arrhythmics. In 38% of the respondents, circadian rhythm disorders are manifested by a decrease in the level of working capacity. It is noted that an increase in workload, a change in lifestyle and daily routine affects circadian rhythms and prevails in senior students.

Молодежный инновационный вестник. 2023;12(S2):74-77
pages 74-77 views


Vugernichek A.Y.


Молодежный инновационный вестник. 2023;12(S2):77-80
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Ionova A.S.


Relevance: Aging is a physiological, increasing with age, destructive process that leads to a decrease in the adaptive abilities of the body. Aging is an irreversible process, but it can prolong (or lengthen) for many decades by maintaining active longevity.Objective: To study the main demographic indicators of the population: mortality, fertility, population size and life expectancy.Materials and methods: The analysis was carried out on the basis of data taken from the official website of the Territorial Body of the Federal State Statistics Service for the Voronezh Region.Results: It was revealed that in recent years the birth rate has decreased by 1.4 times (2015-2021), the indicator of life expectancy decreased by 4.1 years, and mortality increased by 1.4 times (2019-2021). There is an increase in the number of elderly people, which contributes to the dominance of the mortality rate over the birth rate.Conclusion: The population of the Voronezh Region is subject to an intensive aging process. To improve the main indicators, the demographic policy "On the approval of the concept of demographic policy of the Voronezh Region for the period up to 2025" was implemented. This policy plans not only to increase the birth rate, but also to improve the quality of life of the entire population. Currently, the project has not brought the desired results, but the work that is being carried out in this direction contributes to the improvement of the main demographic indicators.

Молодежный инновационный вестник. 2023;12(S2):80-81
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Karakhanova S.Y.


Relevance. Acute respiratory viral infections are a group of infectious diseases characterized by a common mechanism of transmission and clinical symptoms of damage to the upper and lower respiratory system in the gradation from mild to extremely severe severity.

Goal. To study the features of the etiological structure of acute respiratory viral infections, with the exception of the pandemic strain of coronavirus, in outpatient and hospitalized patients of the Voronezh region for the period 2018-2021.

Methods. A retrospective analysis of 15,890 results of studies of clinical material from 2,545 patients for non-pandemic viruses of respiratory infections was carried out. The study was conducted on the basis of the virological laboratory of the Center for Hygiene and Epidemiology in the Voronezh region for 2018-2021 by polymerase chain reaction, with the exception of the pandemic strain of coronavirus, with hybridization–fluorescence detection in real time. Intensive and extensive indicators were calculated.

Results. 708 positive results were obtained (4.46%). The etiological structure of ARVI was characterized by pronounced diversity. In 2018, the leading positions were held by influenza viruses of group A (H1N1) – 54.18% (p<0.001), rhinoviruses and adenoviruses. In the structure of 2019, influenza A (H3N2) viruses occupied the largest share – 25.93% (p<0.001), rhinoviruses and bocaviruses. In the first year of the pandemic of a new coronavirus infection, influenza B and A (H1N1) viruses had the greatest share – 28.57% and 25.97%, respectively (p<0.001), rhino-, boca- and coronaviruses occupied equal shares (10.39% each). In the structure of 2021, rhinoviruses (34.15%), influenza A (H3N2) viruses (24.39%) and respiratory syncytial virus (17.07%) took the leading places without significant differences with each other (p>0.05).

Conclusions. In the subgroup of outpatient and hospitalized patients with positive ARVI results during the studied period, the etiological structure was characterized by pronounced diversity; the leading places were occupied by influenza viruses of group A and rhinoviruses.


Молодежный инновационный вестник. 2023;12(S2):82-84
pages 82-84 views


Lagunova O.R.


Relevance: Cervical cancer (CC) in the global structure of malignant neoplasms in women ranks 4th in terms of morbidity and mortality. According to the World Health Organization, more than half a million women get sick every year and about 300,000 die from cervical cancer. Most often, cancer affects women of childbearing age.
Purpose: Epidemiological analysis of the incidence of cervical cancer in the female population for the period from 2009 to 2021.
To assess the awareness of the population of the Voronezh region (VO) about the etiology and prevalence of cervical cancer through an anonymous survey using a Google form.
Methods: Retrospective epidemiological analysis of cervical cancer incidence over a 13-year period. Statistical processing of anonymous survey data and materials of accounting and reporting forms using the Excel package.
Result: According to the results of a retrospective epidemiological analysis of the incidence of cervical cancer in the population of the Russian Federation and VO, a decrease in incidence rates for the analyzed period was established. On the territory of the Russian Federation until 2019, there was an increase in the incidence rate by an average of 0.45 per 100 thousand population, from 2019 to 2021. there was a decrease in the incidence rate by 12.5%.
On the territory of the VO, the incidence rate of cervical cancer is 25.5% lower than the values of the Russian Federation. From 2009 to 2011 there was a decrease in the incidence to 13.92 per 100 thousand of the population, then until 2016 there was an increase in the incidence and in 2015 the maximum rate was recorded - 20.03 per 100 thousand of the population during the study period, after the incidence decreases by 2021 (13.5 per 100 thousand population).
An anonymous survey was conducted to assess the awareness of the population of the VO about cervical cancer, the causes of occurrence and the degree of prevalence. The survey involved 100 respondents aged 18 to 71, of which the proportion of men was 13%, the proportion of women - 87%. According to the respondents, the human papillomavirus (HPV) is the causal factor in the onset of the disease, and in the structure of malignant neoplasms in women, it ranks second or third. The first cases of the disease, according to 78% of respondents, are registered at the age of 20-30. The average age of detection of CC was 36-40 years, indicated by 38% of the respondents. In the question "can men be a source of HPV infection?" 16.2% answered negatively, 33% of respondents believe that in our country there is a domestic HPV vaccine.
Conclusion: The incidence on the territory of the Russian Federation and VO for the analyzed period tends to decrease.
As a result of an anonymous survey, a good awareness of the population of VO about cervical cancer was established. Shortcomings in the knowledge of respondents about the etiology and vaccination with domestic drugs were revealed.

Молодежный инновационный вестник. 2023;12(S2):84-87
pages 84-87 views


Smolyak A.A.


Relevance: The problem of HIV infection continues to be relevant, despite the stabilization of morbidity since the height of the epidemic. Knowledge and understanding of the risk factors of infection, as well as the ways of HIV transmission, is at the heart of successful prevention strategies that should combine not only medical interventions, but also a behavioral aspect.
Injecting drug users remain one of the population groups in which high levels of HIV infection are registered, as before. Awareness-raising among high-risk groups is an integral part of HIV infection prevention.

Objective: To assess and analyze the awareness of the high-risk group - injecting drug users, about the transmission routes and risk factors of HIV infection for 2021 in Voronezh.

Materials and methods: The materials for the study of awareness among the high-risk group were questionnaires obtained as a result of projects among key population groups implemented by the "VOCCPiBS" in the territory of Voronezh in 2021.

Results: During the entire period of observation, the path of infection of Russian citizens was established in 96.7% of cases of infection, of which 50.5% are infected with intravenous drug use. An important component of the research work was the implementation of its practical part - the survey of citizens belonging to the high-risk group. 223 people took part in the survey. According to the survey, the ratio of respondents by gender was characterized by a predominance of 80% men over 20% women. The average age of the respondents was 33 years. The average experience of drug use was 10 years.
The survey revealed an insufficient level of awareness of respondents about the ways of HIV transmission (74%). According to respondents, unprotected sexual contact with a person whose HIV status is unknown is in the first place among the ways of HIV transmission (92%), the use of common (non-disposable or non-sterile) needles and syringes for injections is in the second place (91%), the use of non-sterile equipment for piercings and tattoos (76%).
7.6% of the respondents do not exclude the possibility of contracting HIV infection from mosquitoes, when shaking hands, kissing, when visiting the pool. 80% of respondents trust the information received from medical professionals, 67% prefer the helpline of the AIDS Center, only 15% prefer to receive information from the media (including the Internet).

Conclusion: The survey conducted showed insufficient awareness among the high-risk group - injecting drug users. In order to prevent HIV infection in this group, systematic information and educational work should be carried out aimed at raising awareness about the disease and risk factors.

Молодежный инновационный вестник. 2023;12(S2):87-89
pages 87-89 views


Taranenko A.E.


Relevance: The problem of parenteral viral hepatitis is relevant at the present time. According to the WHO (World Health Organization), 325 million people are living with viral hepatitis B or C. The Global Health Strategy on Viral Hepatitis 2016-2021 set out plans to fight the disease worldwide. Today, the program is focused on the period up to 2030. The goal was to eliminate viral hepatitis, and the global target was to reduce new infections by 90% and deaths from viral hepatitis by 65% ​​by 2030.

Purpose: To analyze the awareness of medical students about risk factors, prevention and transmission routes of parenteral viral hepatitis.

Materials and methods: A questionnaire was developed, which includes 20 questions. The questionnaire consisted of three sections: 1) questions reflecting: information about the respondent (gender, course of study, work, etc.; 2) awareness of the ways of transmission of viral hepatitis B, C; preventive measures; 3) awareness of students in the issues of vaccination. Statistical processing was carried out using the computer program Microsoft Excel.

Results: According to the survey, the ratio of respondents by sex was characterized by the predominance of women 66% over men - 34%. The average age of students is 20.63±0.19 years. Medical students have the opportunity to work in medical organizations, and thus are at risk of contracting blood-borne infections in the event of an emergency. The questionnaire method is applicable for correcting the knowledge gained during training. The validity of these surveys, as well as their significance in the educational policy of the university, is of great importance. The results obtained in the course of the study are necessary for more rational actions in the educational processes of the university and the improvement of educational programs and learning technologies.

Conclusion: An analysis of the respondents' answers showed that the problem posed is significant and relevant in our time. However, some students need to continue working on the formation of knowledge about risk groups, prevention and the need for vaccination.

Молодежный инновационный вестник. 2023;12(S2):89-91
pages 89-91 views


Churbanova N.Y.


Currently, there are many methods of therapeutic starvation, the main purpose of which is "cleansing the body." In this article, fasting according to Shelton was chosen to evaluate the effectiveness - this is fasting on water, when the drinking regime is not limited, and cleansing enemas and laxatives are not used. Fasting helps to remove unnecessary and harmful substances accumulated in the body, activate autophagy processes, normalize the function of the digestive tract and, of course, reduce dependence on food, develop self-discipline. Also, a stable hormonal background, acid-base balance and water-electrolyte balance are established. Based on this, after the expiration of the fasting period, blood pressure and pulse should normalize, swelling should decrease, activity indicators will increase and well-being will improve. The effect of fasting on the psychophysiological parameters of the human body and the functioning of the cardiovascular system before and after fasting was studied. To assess the effectiveness of the technique, the following criteria were used: blood pressure, pulse, the presence of edema, a well-being-activity-mood test. As a result of the study, the positive effect of fasting according to the Shelton method on the human body was determined: blood pressure and pulse indicators normalized, edema recorded before fasting disappeared , general well-being has improved, new forces have appeared for various types of activities.

Key words: fasting, Shelton, cleansing, well-being-activity-mood test, edema.

Молодежный инновационный вестник. 2023;12(S2):91-93
pages 91-93 views

Внутренние болезни


Axelrod M.M.


Relevance. Despite the fact that coronary heart disease, as a separate disease, is quite well studied, there are many less developed problems associated with the combination of coronary artery disease and other nosologies. According to many authors, it has been established that patients with COPD are much more likely to die from cardiovascular pathology than from COPD itself. It was determined that people with COPD have the most severe atherosclerotic lesions of the coronary arteries in comparison with the group without COPD. There are various classifications of COPD, but none of them reflects the relationship between the severity of coronary atherosclerosis and the COPD phenotype. In this regard, the evaluation of coronary lesions in patients with various COPD phenotypes is of increased interest.

Purpose. Determination of the COPD phenotype most susceptible to severe coronary atherosclerosis.

Materials and methods. The study involved 74 people with a diagnosis of chronic obstructive pulmonary disease, which was confirmed and verified by clinical and functional methods and standardized criteria. All patients were confirmed to have coronary atherosclerosis by coronary angiography. The severity of coronary atherosclerosis was assessed by the Gensini index.

Results. The COPD phenotype most susceptible to coronary atherosclerosis was identified according to coronary angiography data.

Conclusion. According to the study, the risk of developing coronary atherosclerosis in this COPD phenotype is the highest, which can be used as a prognostic indicator at the outpatient stage.

Молодежный инновационный вестник. 2023;12(S2):94-96
pages 94-96 views


Alekseeva A.V., Selimov G.R.


RELEVANCE: currently there is a sharp increase in the incidence of echinococcosis in the Astrakhan region.
PURPOSE: a case of cardiac echinococcosis was demonstrated on a clinical example.
MATERIALS AND METHODS: Case history of patient U., 22 years old, results of laboratory and instrumental studies.
RESULTS: Patient U., 22 years old, was admitted for surgical treatment to the Federal Center for Cardiovascular Surgery in Astrakhan seven days after the onset of the disease and the appearance of the first complaints. During this time, a clinical examination was performed, including laboratory tests (OAC, biochemical blood test) and instrumental studies (CT of the abdomen, chest, brain, ECHO-KG). After the preparatory treatment of CHF, the patient underwent surgical treatment "Removal of the echinococcal cyst of the heart." After 8 days the patient was discharged.
CONCLUSION: the diagnosis of echinococcosis is of paramount importance, it helps to detect the disease at an early stage. The given example describes a fairly quick diagnosis, the correct tactics for managing a patient. The data of examination and diagnostic search are given. The conclusions outline the problems of diagnosing echinococcosis and ways to solve this problem.

Молодежный инновационный вестник. 2023;12(S2):96-98
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Allakhverdiev L.M.


Annotation. A clinical case of a patient with Chf (chronic heart failure with a reduced ejection fraction) is presented. The article evaluates the effectiveness of the use of such a drug as dapagliflozin, a type 2 sodium-glucose cotransporter inhibitor aimed at improving the patient's condition and reducing the risk of cardiovascular mortality.

Aim.To evaluate the effectiveness of the drug dapagliflozin in the treatment of chronic heart failure on the example of a clinical case.

Materials and methods. The object of the study is the medical documentation of a patient of the Orenburg city polyclinic.The research method was the analysis of the medical record, evaluation of the results of examination and treatment.

Results. The therapy was carried out in the period from October 2021 to November 2022. It showed positive results. During this period of observation, the symptoms of heart failure did not worsen, the condition remained satisfactory. When performing EchoCG, an improvement in LV contractility was noted in dynamics, which is expressed in a decrease in LV volume and an increase in the ejection fraction from 39% when prescribing therapy to 45%.

Сonclusion. CHF is the "finale" of cardiovascular diseases. If earlier patients with CHF had an unfavorable outcome, now with proper therapy it is possible to improve the life and condition of patients.This clinical example shows that the addition of dapagliflozin to the standard therapy for the treatment of CHF rEF FC II showed a positive effect associated with an improvement in clinical symptoms and quality of life.


Молодежный инновационный вестник. 2023;12(S2):98-100
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Valiulin R.I., Ibragimova L.M., Khasanova M.S.


Annotation: systemic lupus erythematosus (SLE) is a systemic connective tissue disease of an autoimmune nature, which leads to immunoinflammatory damage to internal organs, and sometimes to death. According to the epidemiological study (USA, 1999–2016, n = 45 million people), in patients with SLE (n = 95 thousand, 0,21%), heart damage was recorded much more often than in the control group: rhythm disturbances and conduction - in 22% and 6%, coronary artery disease - in 13% and 4%, significant valve damage - in 11% and 2%, myocardial infarction (MI) - in 6% and 2%, pulmonary hypertension - in 2,2% and 0,2%, HF — in 1,0% and 0,2% of patients, respectively. In addition, the male gender is a risk factor for the development of cardiovascular diseases. In men, the risk of developing coronary heart disease (CHD) is about 3 times higher than in women of the same age with the same level of cholesterol. Purpose: to study the features of the course of SLE in male patients and complications from the cardiovascular system (CVS). Methods: for the study were studied the medical histories of 35 men with SLE who were treated inpatient at the Cardiorheumatology Department of the Tashkent Medical Academy Clinic from 2017 to the current year. The results of their therapeutic examination and diagnostic measures were analyzed. To compare the data about male patients’ complications, a group of female patients was collected. Results: the classic risk factor for the development of cardiovascular diseases (arterial hypertension) was more often observed in older age groups of patients, but it also occurred in almost 50% of cases in young patients. Hypoxic changes in the myocardium were present in more than half of the men. It was also noted that cardiovascular lesions: valvular defects, aseptic necrosis of the femoral head, Raynaud's syndrome, stroke and heart attack, which were not observed or were rare in the female comparison group, were often observed in men. Conclusion: male gender is one of the risk factors for developing cardiovascular diseases, which is even more aggravated when the patients have complications are caused by systemic disease. According to our study, it was possible to determine that men are more difficult to tolerate the disease and they can expect more serious damage to the cardiovascular system.

Молодежный инновационный вестник. 2023;12(S2):101-102
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Glavatskikh Y.O., Tokmachev R.E., Budnevskaya S.A., Drobysheva V.R.


Background. Since the beginning of the pandemic, the number of coronavirus infections has reached 662,221,274 and the number of deaths has reached 6,701,780. These figures are largely due to the decompensation of heart failure as a result of the addition of SARS-CoV 2 infection.  Increased levels of cardiac biomarkers during coronavirus infection reflect excess inflammation, viral load, cytokine storm, and an atherothrombotic process that can cause direct or indirect heart damage.

Objective. To study the level of NT-proBNP in patients with chronic heart failure who have had COVID-19.

Materials and methods. The study included patients aged 40 to 70 years diagnosed with CHF of ischemic genesis hospitalized with a positive polymerase chain reaction (PCR) smear for SARS-C infection about V-2 (n = 60). The control group consisted of patients hospitalized with a positive PCR smear for SARS-C infection about V-2, without signs of HF in the anamnesis ( n=20). All patients underwent laboratory methods: general clinical and enzyme immunoassays of blood with determination of NT-proBNP levels.

Results. The average NT-proBNP level in patients with CHF and Covid-19 was significantly higher than its value in patients without a history of CVD.  In patients with source III FC CHF (subgr. 1. 3) the level of the biomarker significantly exceeded its value in patients witho II FC CHF and in patients with I FC CHF (subg.1.1)..  The ratio of the odds of a favorable course of CHF and Covid-19 or the transfer to the ICU of patients with CHF and Covid-19 depending on the level of Nt-proBNP (threshold value of ˃300 pg / ml) was studied.  The resulting OR was 12.27, [95% CI 1.53567; 98.1617]. Consequently, the probability of not getting into the ICU in patients with an NT-proBNP level  below the threshold is 12.27 times lower than in patients with an Nt-proBNP level  of ˃300 pg / ml. Also, the ratio of the chances of a favorable course of CHF and Covid-19 or death depending on the level  of Nt-proBNP was studied.  (threshold value ˃300 pg/ml).  The resulting OR was 2.43 [95% CI 0.564593; 10.5233]. Therefore, the probability of non-occurrence of such a checkpoint as death in patients with an NT-proBNP level  below the threshold is 2.43 times lower than in patients with an Nt-proBNP level  of ˃300 pg / ml.

Conclusion. Threshold values  for cardiac  biomarkera (NT-proBNP) for stratification and isolation of risk groups among patients with Covid-19, CHF and Covid-19  have been determined. In patients with Covid-19 and CHF, a strong association has been found between high levels of the cardiac biomarker (Nt-proBNP) and a negative short-term prognosis (ICU transfer/death).  Thus, in patients with CHF and Covid-19 against the background of hypoxia, systemic subclinical inflammation, damage and apoptosis of cardiomyocytes occur, which as a result leads to structural-functional and electrical remodeling of the ventricles with decompensation of heart failure.

Молодежный инновационный вестник. 2023;12(S2):103-105
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Glavatskikh Y.O., Tokmachev R.E., Budnevskaya S.A., Drobysheva V.R., Chernik T.A.


Background. A lot of viruses affect the heart, both as a result of direct viral processes and through indirect mechanisms associated with the body's immune response [1]. Analysis of the results of numerous studies leads to the conclusion that an absolute increase in the activity of viral diseases by 5 to 7% is directly related to an increase in the frequency of hospitalizations for heart failure by 24% or more. An increase in the levels of cardiac biomarkers during Coronavirus infection reflects excess inflammation, viral load, cytokine storm and atherothrombotic process, which can cause direct or indirect damage to the heart.

Objective. To study sST2 levels in patients with chronic heart failure and COVID-19.

Materials and methods. The study included patients aged 40 to 70 years diagnosed with CHF of ischemic genesis hospitalized with a positive polymerase chain reaction (PCR) smear for SARS-C infection about V-2 (n = 60). The control group consisted of patients hospitalized with a positive PCR smear for SARS-CoV-2, without signs of HF in the anamnesis ( n=20). All patients underwent laboratory methods: general clinical and enzyme immunoassays of blood with determination of the level of sST2.

Results. When conducting research, the protein level was determined sST2. In the second group of patients without symptoms and signs CHF level of this biomarker was statistically significantly less compared to gr. 1 (CHF and Covid-19). It is worth noting that the level sST2 at patients with CHF increased with the increase in FC HSN. Higher levels of sST2 in patients with CHF with increasing FC Can reflect more pronouncedе process hypertrophy and myocardial remodeling и Evidence. It's a lot of work. that the induction of sST2 is caused by mechanical overload of cardiomyocytes. Accordingly, an increase in the level of this biomarker may reflect myocardial stress, the processes of changes in the architectonics of the heart during the development of CHF and fibrosis.  Also, the ratio of chances of a favorable course of CHF and Covid-19 or fatal depending on the level sST2 (threshold ˃35 нg/ml).  The frequency of non-occurrence of such a checkpoint as death in patients with a level of sST2 below the threshold in 8,14 times lower than in patients with a level sST2˃35 нg/ml.

Discussion: An increase in sST2 levels in CHF patients after Covid-19 may indicate an intensification of the myocardial remodeling process. The data obtained in the study are consistent with the scientific hypothesis of an increase in sST2 production in mechanically overloaded cardiomyocytes, reflecting myocardial stress, ventricular remodeling, and fibrosis.

Conclusion: Thresholds for cardiac  biomarker a (sST2) for stratification and isolation of risk groups among patients with Covid-19, CHF and Covid-19 have been determined. In patients with Covid-19 and CHF, there is a strong association between high levels of sSt2 and a negative short-term prognosis (ICU transfer/death).  The analysis of the level of sST2 allows us to draw conclusions about the prospects of its implementation in the diagnosis and prognosis of the course  in patients with CHF, as a biomarker of myocardial stress, ventricular remodeling and fibrosis.

Молодежный инновационный вестник. 2023;12(S2):105-107
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Klepov A.A.


Relevance. The problem of psychosomatic disorders remains one of the urgent problems of modern medicine, in particular, it is relevant in gastroenterology. The appointment of psychotropic drugs is mentioned in the latest clinical recommendations for the treatment of chronic pancreatitis and irritable bowel syndrome, however, medical care for the contingent of patients with these diseases is often insufficient, as evidenced by a large percentage of repeat referrals and short clinical remission.
Objective. Analysis of the severity of anxiety and depression in patients with pathology of the gastrointestinal tract who sought medical help in the BUZ IN VGKP No. 7 for the period from 20.04.22 to 13.05.22.
Methods. Five groups of patients were evaluated according to nosological units (gastric ulcer and/or duodenal ulcer, chronic pancreatitis, gastroesophageal reflux disease, irritable bowel syndrome and a group of patients with multiple pathology of the digestive system). The following questionnaires were used: the Hospital Anxiety and Depression Scale (HADS) and the Gastrointestinal Tract Symptoms Assessment Scale (GSRS).
Results. Manifestations of the main syndromes of chronic diseases of the digestive system were more pronounced in patients with anxiety and/or depression. Most patients with anxiety and depression were found in the group with multiple pathology of the digestive tract. Patients with chronic pancreatitis had the maximum severity of abdominal pain syndrome, reflux syndrome - patients with gastroesophageal reflux disease, dyspeptic – with multiple pathology of the digestive system, diarrheal syndrome and constipation syndrome – with irritable bowel syndrome.
Conclusion. Anxiety-depressive disorders increase gastrointestinal manifestations of chronic diseases of the digestive tract, and those, in turn, contribute to the increase of anxiety and / or depression, forming a vicious circle, therefore, treatment of such patients should be comprehensive.

Молодежный инновационный вестник. 2023;12(S2):107-110
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Martynenko D.A., Lagutina S.N., Zuikova A.A., Skuratova O.S.


The aim of the work is to assess adherence to antihypertensive therapy in patients with cardiological and nephrological profile, depending on their age, level of education and gender, as well as to search for risk factors that significantly aggravate the course of the disease.Materials and methods: this work was carried out on the basis of BUZ IN VGKP No.4. The study involved patients suffering from arterial hypertension (30 men and 30 women), whose average age is 52 years. The Morisky-Green test was used - a clinical and psychological test technique designed for preliminary assessment of compliance and screening detection of insufficiently compliant patients in routine medical practice.Results: among the patients who were on outpatient observation by a cardiologist, a nephrologist, half of the respondents have a fairly low adherence to the prescribed therapy. For more effective treatment of patients with arterial hypertension, in addition to drug therapy aimed at a steady decrease in blood pressure, self-control and adherence to medication are necessary. In order to achieve the desired goals and objectives of the study, to increase patients' adherence to treatment, it is necessary, mainly, to establish a doctor-patient contact.Conclusions:The global problem of outpatient therapy of arterial hypertension is low awareness of risk factors, rather high cost of medications, fear of side effects, lack of significant effect from drug therapy, unwillingness to take long-term, regular medications. All of the above indicates a low adherence of patients to antihypertensive therapy – in 69% of cases.

Молодежный инновационный вестник. 2023;12(S2):110-112
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Petrikhina O.N.


Relevance. Currently, rheumatic diseases (RD) are the most common pathologies in practical medicine. They are one of the frequent causes of a persistent decrease in working capacity, the development of disability. Because of this, the number of cases of patients visiting a doctor is steadily growing. Therefore, the study of the prevalence of rheumatic diseases is of no small importance in their diagnosis and treatment.
Purpose: to determine and evaluate the prevalence of the main and concomitant nosological forms of rheumatic diseases in patients of different age categories.
Materials and methods: The study involved 408 patients who were treated at the VUZ VO VGKB No. 20 on the basis of the rheumatology department from February 2022 to January 2023. As a result of the work, all patients were divided into two groups by gender: women and men. Then, in each group, based on age, 6 categories are allocated. They calculated the percentage of patients with the same underlying rheumatic disease, and also identified their comorbidities.
Results: The number of women of the total number of patients was 61.76%, men - 38.24%. In 12 women aged 20-30 years (the first age category), rheumatoid arthritis is diagnosed as the main diagnosis, which is accompanied in 2.941% of cases by type 2 diabetes mellitus, hypertension (AH) grade 2, risk 4 and chronic bronchitis. Men of this age were not treated.
Conclusion: When examining rheumatological patients, a doctor of any specialty needs to know that rheumatoid arthritis, systemic scleroderma and SLE are most common among women, rheumatoid arthritis, psoriatic arthritis and primary gout among men. Among comorbidities, the leading place is occupied by hypertension of varying degrees and risk, coronary artery disease, as well as chronic renal failure, chronic pyelonephritis, osteoporosis, bone fractures, and type 2 diabetes mellitus.

Молодежный инновационный вестник. 2023;12(S2):113-115
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Ryaboshlyk V.R.


Relevance. Modern anticancer drugs and treatment regimens can achieve an increase in the survival of cancer patients, but they often cause cardiotoxicity. Timely detection of damage to the heart muscle and early initiation of cardiotropic therapy will make it possible to successfully carry out the planned chemotherapy treatment.

Target. To assess the cardiotoxicity of chemotherapy regimens in cancer patients.

Methods. The study included 40 patients with morphologically verified diagnoses: breast cancer and lung cancer, who received chemotherapy treatment. Patients were divided into 2 groups, identical in stages and morphological verification. Patients of the first group with a diagnosis of breast cancer received chemotherapy according to the AC scheme, patients of the second group with lung cancer received chemotherapy according to the EU scheme or paclitaxel + carboplatin. The study of cardiotoxicity was carried out by the methods of electrocardiography, echocardiography, daily monitoring of ECG and blood pressure with an assessment of the average daily heart rate in the daytime and at night, a diagnostically significant shift of the ST-T segment, the average daily value of systolic (SBP) and diastolic (DBP) blood pressure. Blood pressure above 140/90 mm was considered as the criterion for arterial hypertension. rt. Art.

Results. Both groups of patients were initially comparable in terms of clinical parameters and comorbidities. The results of the study of cardiotoxicity were evaluated after a course of chemotherapy. When evaluating the results of electrocardiography, it was found that patients of the first group significantly more often had impaired intraventricular conduction (Δ10.3%, p<0.05) and repolarization processes (Δ9.6%, p<0.05). An echocardiographic study showed a comparable decrease in the contractility of the left ventricle in both groups of patients. When analyzing the results of 24-hour ECG monitoring, a comparable increase in the average heart rate during the day and at night was found in both groups of patients. When assessing the dynamics of the ST-T segment, the difference between the groups was Δ11.9% (p<0.05). With daily monitoring of blood pressure, a comparable increase in the average daily SBP and DBP was found in both study groups.

Conclusions. In the course of the study, the presence of a cardiotoxic effect of chemotherapy in patients with breast and lung cancer was proved. At the same time, after a course of chemotherapy in patients of the first group, such manifestations of cardiotoxicity as impaired intraventricular conduction, repolarization processes, and depression of the ST-T segment were significantly more common.

Молодежный инновационный вестник. 2023;12(S2):115-117
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Tokmachev R.E., Glavatskikh Y.O., Budnevskaya S.A., Drobysheva V.R.


Background. Analysis of the results of numerous studies allows us to conclude that an absolute increase in the activity of viral diseases by 5 to 7% is directly related to an increase in the frequency of hospitalizations for heart failure by 24% or more.  Since the beginning of the pandemic, the number of coronavirus infections has reached 662,221,274 and the number of deaths has reached 6,701,780. These figures are largely due to the decompensation of heart failure as a result of the accession of respiratory infections and other intercurrent diseases.  The main systemic effect of Covid-19 is systemic inflammation.  At the same time, the underlying mechanisms are quite diverse and have not yet been sufficiently studied.

Objective. To study the level of systemic inflammation indicators (levels of circulating TNF-α, IL-1β, IL-6) in patients with chronic heart failure who have had COVID-19.

Materials and methods. The study included patients aged 40 to 70 years diagnosed with CHF of ischemic genesis hospitalized with a positive polymerase chain reaction (PCR) smear for SARS-C infection about V-2 (n = 60). The control group consisted of patients hospitalized with a positive PCR smear for SARS-C infection about V-2, without signs of HF in the anamnesis ( n=20). All patients underwent laboratory methods: general clinical and enzyme immunoassays of blood with the determination of the levels of IL-1β, IL-6, TNF-α.

Results. The analysis of cytokine status indicators demonstrated an increase in  the levels of pro-inflammatory cytokines in all the studied subgroups in comparison with their levels in 2021 with a stable course of CHF. At the same time,  there were no significant differences in the content of IL-1β, IL-6, TNF-α in the studied groups.

Concluson. Thus, the course of the new coronavirus infection is accompanied by an aggressive inflammatory reaction with the release of a large number of pro-inflammatory cytokines, which can be considered as potential markers of the prognosis of the course and outcomes of the disease in both patients with CHF and patients without HF.

Молодежный инновационный вестник. 2023;12(S2):117-119
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Tokmachev R.E., Glavatskikh Y.O., Drobysheva V.R., Budnevskaya S.A.


Background. CHF is an urgent medical social problem, characterized byits steady growth over the years. Currently, more than 12 million people in the territory of the Russian Federation suffer from CHF.  Despite the progress made in therapy, the mortality rate from CHF is still high. Patients diagnosed with CHF have steady progress in the course of the disease and are subject to constant hospitalizations, which further leads to persistent disability and loss of working capacity. Also, it is known that the transfer of viral infections often leads to decompensation of HF.  Thus, an increase in the levels of cardiac biomarkers during coronavirus infection may reflect direct or indirect myocardial damage.

Objective To study the level of hs-TnT in patients with chronic heart failure and COVID-19.

Materials and methods: The study included patients aged 40 to 70 years with a diagnosis of CHF of ischemic genesis, hospitalized with a positive polymerase chain reaction (PCR) smear for SARS-C o V-2 infection (n = 60). The control group consisted of patients hospitalized with a positive PCR smear for SARS-C infection about V-2, without signs of HF in the anamnesis (n=20). All patients underwent laboratory methods: general clinical and enzyme immunoassays with determination of the level ofi hs-TnT.

Results: In both the CHF patient group and the control group, in more than 70% of cases, patients had elevated hs-TnT levels, which may indicate acute cardiomyocyte damage in most age-related individuals with Covid-19 infection.  It was found that in a subgroup of patients with cholesterolH, the level of hs-TnT was statistically significantly higher in comparison with gr. 2 (patients without CHF in the anamnesis).  At the same time, in patients of I FC, the level of hs-TnT  was statically significantly lower than in patients of II FC and III FC.  Interms of non-entry intothe NICU, patients with hs-TnT levels below the threshold level are 6.7 timeslower than those with hs-TnT levels of ˃30 ng/ l. In the frequency of non-occurrence of such a checkpoint as death, in patients with a level of hs-TnT below the threshold is 3.4 times lower than in patients with a level of hs-TnT ˃ 30 pg / ml.  It was also noted that normal levels of hs-TnT upon admission were associated with 100% survival rate.

Conclusion: Thresholds for  the cardiac  biomarkera (hs-TnT) for stratification and isolation of risk groups among patients with Covid-19, CHF and Covid-19 have been determined. In patients with Covid-19 and CHF, there is a strong association between high levels of hs-TnT and a negative short-term prognosis.  

Молодежный инновационный вестник. 2023;12(S2):119-121
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Shtanova A.A., Stepina D.A., Kupriyanova I.N.


Relevance. The number of patients with chronic kidney disease stage 5  on program hemodialysis is more than two million people worldwide. This category of patients has disorders of phosphorus-calcium metabolism. The effect of blood flow velocity to maintain optimal levels of calcium (Ca), phosphorus (P) and the ratio of calcium and phosphorus (Ca x P) in serum in patients with PGD has not been studied.
The purpose of the study was to determine the relationship between blood flow velocity and calcium-phosphorus metabolism in patients on program hemodialysis; determination of the number of patients who have reached the target indicative indicators of calcium-phosphorus metabolism according to KDOQI and KDIGO.
Materials and research methods. A retrospective study of 67 medical records was conducted at Ural Medical Center LLC from January to March 2022. The following features were evaluated: demographic data such as age, gender, laboratory parameters (calcium, phosphorus, parathyroid hormone, phosphorus and calcium product) , blood flow velocity (ml/min, CKT). Statistical analysis of the data was carried out using Statistica 13.0. Research results.

A retrospective study of 67 medical records was conducted at Ural Medical Center LLC from January to March 2022. The following features were evaluated: demographic data such as age, gender, laboratory parameters (calcium, phosphorus, parathyroid hormone, phosphorus and calcium product) , blood flow velocity (ml/min, CKT). Statistical analysis of the data was carried out using Statistica 13.0. Research results.

In all groups, the levels of calcium and phosphorus were within the normal range, while the target levels of PTH were not achieved in any group. The maximum calcium level was in group 2 (2.27 ± 0.14 mmol/l), slightly lower in group 1 (2.22 ± 0.14 mmol/l), and the lowest in group 3 (2.19 ± 0.08 mmol/l) (p<0.001). There were no significant differences in the levels of phosphorus and parathormone between the study groups of patients. There was no correlation dependence of CKT with any indicator (p>0.05). Conclusion: Our study showed no correlation between CKT and calcium, phosphorus, and parathyroid hormone.

Молодежный инновационный вестник. 2023;12(S2):122-124
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Yashkova M.A.


Coronavirus infection for the period of its existence and today is a disease to which the eyes of the public health and the world community are constantly turned, because despite the apparent dynamics of reducing the incidence due to compliance with all anti-epidemic measures, there is still a threat of outbreaks and modification of the RNA-containing virus of the Coronaviridae family. Thus, when assessing the burden of COVID-19, the results were summed up – the economic component suffered, there was a social protest against self-isolation measures, changes were identified in the procedures for preventive measures, and a lot of work was done in the re-equipment of departments for patients with a New coronavirus infection, the purchase of additional equipment and research in this area.


Analysis of the course of covid infection with standard methods of treatment, depending on the degree of lung damage according to CT data.

Materials and methods

A retrospective analysis of 93 case histories was carried out on the basis of the BUZ IN "VGKBSMP No. 10". Laboratory, clinical and instrumental research methods were carried out. In the study group, the number of women was 53%, men - 47%. Statistical data processing was performed using Microsoft Office Excel – analysis of the mean value and standard deviation, evaluation of the value of variables of average values using the parametric Student t-test, as well as Spearman correlation.

The results of the study. In all patients – subfebrile temperature, with CT-2-4 increase in heart rate, CT-2-4 increase in BPD. ESR is an increase in CT-0-4. Indicators of general metabolism: glucose – increase with CT-0-3; indicators of liver failure: total bilirubin – increase with CT-4, AlAt – hanging with CT-3-4, AsAt increase with CT-0-4; indicators of renal failure: urea – increase in 1 day with CT-2, creatinine – increased upon admission of CT-0. CRP is an increase in CT-0-4. Ferritin – increased CT-0-4. Indicators of homeostasis: fibrinogen and INR – a slight increase in CT-0-4.


Based on the analysis of the course of covid infection with standard methods of treatment, depending on the degree of lung damage according to CT, we can conclude that women are most often ill, the average age is 61-70 years. Women are more seriously ill, since CT-4 is more common at the time of admission, CT-1 is more common in men. Throughout the day, patients with CT-0-4 had elevated ESR, CRP, ferritin, fibrinogen, INR and an increase in individual indicators at different stages of CT. Individual indicators may be prognostically significant, such as an increase in ESR and platelets, eosinophilia of blood, deviations in liver and kidney function.

Молодежный инновационный вестник. 2023;12(S2):124-126
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Военная и экстремальная медицина


Astafeva O.O., Golubykh R.O.


Relevance. Determining the functional state of military personnel is one of the important areas of military medicine. Many studies cover this problem in sufficient detail, however, it is still relevant to search for methods that will allow you to do this in any conditions, including field conditions. 

Goal. To consider and evaluate the methods of remote study of the functional state of military personnel on the example of cadets studying at the branch of the Military Academy of the RVSN. Peter the Great.Materials and methods. In the course of the work, methods were identified and analyzed that make it possible to study FS remotely using questionnaires, performing functional tests and psychological tests. The subjects for this study were taken from among the cadets of the 3rd faculty of the 3rd year of the branch of the Military Academy of the RVSN. Peter the Great in the number of 16 people. Testing took place between December 20, 2022 and December 25, 2022. Results. The first stage of our work was to create our own questionnaire consisting of 20 questions.   The results showed that among the test group, 50% of people notice any changes in their body, but their number corresponds to the limits of the norm.  The rest of the participants were divided into 2 groups with moderate and mild fatigue with a significant predominance of the latter (37% and 13%). The second stage of the work was the development of precise instructions for self-conducting functional tests, obtaining and analyzing the results from the subjects. The results showed that the excess of normal values (approx. for this age group, the normal values for pulse are 60-80 beats /min, for blood pressure 100-130/70-80 mmHg.) when measuring pulse and blood pressure were not detected. Respiratory samples do not correspond to the reference values in only 3 subjects, which is 18%. An orthostatic test with a heart rate calculation is higher in 1 participant (6%), and a test with a load in 2 (12%).The final stage is the conduct of psychological research. The SAN tests turned out to be very useful for us. During the analysis of the results, it turned out that 2 subjects (12%) had below 4 points in terms of "well-being", 5 (31%) in terms of "activity", 7 (43%) in terms of "mood", the ratio of SAN indicators was violated in 9 (55%) of the study participants.

Conclusions. As a result of the study, material was obtained, the analysis of which shows that the determination of the functional state of military personnel by remote method is possible and quite effective. The methods proposed by us can be used as a screening diagnosis of FS deterioration. Earlier detection of signs of fatigue is the key to successful normalization of the condition of military personnel.

Молодежный инновационный вестник. 2023;12(S2):127-129
pages 127-129 views


Bykova S.A., Baeva V.A.


Relevance. According to WHO experts, a significant share in the structure of mortality due to injuries are those killed in road accidents.

Goal. To analyze road traffic injuries on the territory of the Voronezh Region for the period from 2017 to 2021.

Materials and methods of research. In order to analyze road traffic injuries on the territory of the Voronezh Region, the main data on road accidents, injured and killed as a result of accidents collected by the Voronezh Regional Center for Disaster Medicine for the period from 2017 to 2021 are considered.

 Results. The statistical indicators presented in the paper, obtained by the authors, reflect the problem of injuries not only on the roads of the region, but also of the country as a whole. A comparative analysis of the main statistical indicators of road accidents in the Voronezh region and the Russian Federation is carried out. The characteristic of the structure of sanitary losses as a result of an accident on the territory of the Voronezh region is given. An assessment of mortality in transport accidents during the analyzed period was carried out. According to the results of the work, there is a decrease in the absolute number of affected and dead, as well as injury and mortality rates for the studied period. It is established that the indicators of the region exceed the federal average values. Among the wounded and dead, the dominant majority are able-bodied male citizens.

Conclusion. Due to the fact that the consequences of accidents on the road are of enormous importance for the economic and social significance of the country, it is necessary to further develop and implement a set of systemic measures to prevent road accidents.

Молодежный инновационный вестник. 2023;12(S2):129-131
pages 129-131 views


Volkova S.A., Levchenko L.E.


Relevance. A promising direction in agriculture today is the use of chemical plant protection products — highly toxic pesticides and herbicides — to increase yields and protect against pests and weeds. The need to use such means is obvious, but their use leads to the formation of a large amount of waste in the form of plastic containers with chemical residues that pose a threat to human health and the environment. The Russian Union of Agricultural Producers together with the Association of European Businesses has launched a project: "Collection and disposal of used containers from plant protection products", which allows agricultural producers to hand over waste for recycling.
Aim. To study the effect of pesticides and herbicides on the body of workers of enterprises processing containers from chemical plant protection products, as well as the presence and influence of other occupational harmful factors and ways to organize the safety of life and work in the studied conditions.
Materials and methods. The study was conducted on the basis of the official representative of the manufacturers of chemical plant protection products — LLC "Graphite".
Results. Due to the high toxicity of plastic waste from chemical plant protection products, the work of workers at processing enterprises must be properly and safely organized. The study examines all possible harmful factors of production (directly chemical plant protection products, noise and vibration, a special microclimate) at each stage of waste processing (primary flushing of cans, crushing, secondary cleaning and drying of crushed containers, granulation), their impact on the body of workers is studied and the available ways of organizing the safety of life and work are analyzed in every case. The rationality and safety of the organization of labor is confirmed by the analysis of the facts of the workers' treatment in the health center.
Conclusion. The measures applied in the production practice of the enterprise to organize the safety of life and work provide the necessary protection of employees, which reflects the analysis of the facts of contacting the health center at the enterprise.

Молодежный инновационный вестник. 2023;12(S2):131-134
pages 131-134 views


Gorushkina E.S., Eist N.V., Kurbanov I.B., Pochechueva E.V.


Relevance. The length of Russian railways is 85.6 thousand kilometers, which ensures constant communication even between the most remote points of the country. The low level of operation of railways for sanitary and preventive purposes today requires special attention, since in an emergency this type of transport can make a huge contribution to saving people's lives and the health of the entire population.
Purpose of the study. To study the history of the use of railway transport for sanitary and preventive purposes in Russia, to formulate and justify possible ways of operating railways at the present stage.
Materials and methods. The study of literature, which deals with issues related to the topic under study, the combination of the information received and its consistent presentation, highlighting the beginning of the history of the XIX century.
Results. The experience of using military hospital trains in Russia has a long and significant history. With the start of the work of the first trains that provided evacuation and provided specialized assistance to the wounded and sick right in the car, it became clear that this area of ​​implementation of medical care would become promising. Every year the number of ambulance trains increased, at the same time, the volume of traffic also increased, which made it possible to save millions of lives. The analysis of the information made it possible to identify the ways of development of this direction and highlight the modern interpretation of military hospital trains in the form of health trains.
Conclusion. The volume of traffic, the number of operating trains, and the qualified assistance provided in specialized cars reflect the significant role of railways not only in the implementation of medical care in emergency situations (ES) and in military conflicts, but also in peacetime.

Молодежный инновационный вестник. 2023;12(S2):135-137
pages 135-137 views


Dorokhov A.E., Akperova S.R., Prosvetov S.


According to the World Health Organization (2019-2020) more than 6 million people die each year due to injuries. The aim of the study was to analyze injuries sustained during "SVO", to study qualitative changes in the structure of military injuries, to assess the severity of patients on the ISS scale and the characteristics of medical care.The study group included 52 patients of both sexes who are on inpatient treatment in one of the military hospitals. Data on the structure of injuries, age and sex of patients, as well as on the treatment measures taken were obtained by copying from the case histories. Patients were divided into groups according to the localization of lesions and the leading mechanism of injury. The ISS scale was used to assess the severity of the patients' condition.
The results of the study showed that 60% of all injuries are mine-explosive, 29% are shrapnel wounds, and only 11% are bullet wounds.The most common localization of injuries was the limbs - 56%, abdominal and chest injuries accounted for 15% and 21%, and craniocerebral injuries accounted for only 8%.
In this regard, the provision of medical care to victims in the course of hostilities has its own distinctive features. An unreliable healthcare system is usually the first victim of armed conflict. This is due to the lack of knowledge of military field surgery, as well as resources, which together limit both diagnostic and therapeutic options.

Молодежный инновационный вестник. 2023;12(S2):138-140
pages 138-140 views


Zhdanov V.A., Frolov V.V.


This article discusses the effectiveness of the use of information technology in the structure of disaster medicine. Technological equipment of the disaster medicine service is a necessity that allows to provide medical care more efficiently and quickly, as well as to consult patients using information technology. The greatest need for the use of information technologies is experienced by the field of disaster medicine, since the quality, speed and efficiency of providing assistance to patients, as well as victims in the emergency zone, depends on their implementation. Likewise, the media are a necessary component of disaster medicine and the health care system for effective interaction with the social structures of society.
Purpose: Due to the urgent need to provide medical care in remote areas, it is necessary to point out the effectiveness of the use of telemedicine technologies in this area, thereby provoking their further development.
Materials and methods: Records and data of VOKTSMK on the use of telemedicine technologies by district hospitals for medical consultations with hospitals in the city of Voronezh.
Results: In the process of the conducted research, various patterns were identified, demonstrating which areas use telemedicine technologies more often. There are certain departments that provide consultations more often than others. The types of communication through the telemedicine system are revealed.
Conclusion: At present, it is impossible to imagine everyday life without information technology and other means of communication, this factor also affects the emergence of these means of communication in the field of various public services. These technologies make it possible to achieve the most effective interaction between individual parts, which makes it possible to improve their work for the common good. Thus, the use of information technology is a very popular aspect of many government structures, which will be increasingly in demand in the future.

Молодежный инновационный вестник. 2023;12(S2):140-142
pages 140-142 views


Zyuba Y.P., Kuznetsova A.I.


Relevance. Terrorism is one of the most serious problems of modern society. Due to the current geopolitical situation in the border areas, the risk of terrorist acts within the Russian Federation, including in the Voronezh region, has increased significantly. One of the main tasks facing the state is to strengthen control over compliance with anti-terrorist measures, which are set out in the Federal Law of March 6, 2006 No. 35-FZ "On Countering Terrorism" [2]. The main element of the system of countering terrorism in any state should be the fight against terrorist ideology, which is achieved through the unity of actions of all bodies and organizations designed to participate in ensuring the security of the state and society from terrorist threats. To fulfill these tasks, a center for the prevention of terrorism and extremism was created within the framework of the federal state budgetary educational institution of higher education "Voronezh State Medical University named after N.N. Burdenko".

Objective. Study and evaluation of the effectiveness of anti-terrorist measures carried out by the Center for the Prevention of Terrorism and Extremism at N.N. Burdenko VSMU.

Materials and methods. In the course of the study, the “Regulations on the Center for the Prevention of Terrorism and Extremism of the Federal State Budgetary Educational Institution of Higher Education “Voronezh State Medical University named after N.N. Burdenko” of the Ministry of Health of the Russian Federation”[3]. students about the problem of terrorism, we developed a questionnaire "Anti-terrorist security" and conducted a survey of students. Respondents were asked to anonymously answer 9 questions. Statistical processing of the results was carried out using Microsoft Excel.

Results. 800 students took part in the anonymous survey. After analyzing the results of the questionnaire, it was concluded that the majority of the students surveyed consider the problem of terrorism relevant and are aware of the danger of terrorist acts in modern society. Under the term terrorist, respondents mean a criminal person who deliberately engages in illegal acts. The majority of students consider themselves safe. All this underlines the effectiveness of the work of the Center for the Prevention of Terrorism and Extremism on the territory of the H.H. Burdenko.

Conclusion. Based on the foregoing, we can conclude that the work of the Center for the Prevention of Terrorism and Extremism is an effective measure to combat terrorist activities. In the future, in order to increase the effectiveness of anti-terrorist measures in the face of a growing threat to national security, it is necessary to continue awareness-raising work among students.

Молодежный инновационный вестник. 2023;12(S2):142-145
pages 142-145 views


Karpikova T.S., Soloveva A.A.


Relevance. The predominant category of sanitary losses during armed conflicts are those affected by infectious diseases. In this article, we will study the issue of the impact of infectious diseases on the combat capability of Soviet troops in Afghanistan. Target. To study the impact of infectious disease on the combat capability of a limited contingent of Soviet troops in Afghanistan (1979-1989). Materials and methods. The study was conducted on the basis of the Department of Disaster Medicine and Life Safety of the Voronezh State Medical University. N.N. Burdenko. Results. When studying the literature, it was revealed that infectious processes during the Afghan war (1979-1989) took an atypical course, making it difficult to diagnose and timely treatment, thereby reducing the combat capability of the Soviet troops. The epidemic situation in Afghanistan was complicated by unfavorable climatic and geographical conditions and the same mechanism of transmission of various infections, which was accompanied by an aggravated clinical picture and more often led to an unfavorable outcome of the disease. Conclusion. Thanks to timely changes in the approach to providing specialized medical care to military personnel and a shift in focus to the diagnosis of infectious diseases, doctors managed to maintain the proper combat capability of the Soviet troops, and to some extent increase it.

Молодежный инновационный вестник. 2023;12(S2):145-147
pages 145-147 views


Pogorelov M.D., Kuznetsova V.A.


Relevance. Due to the rapid development of technological progress to date, the dynamics of the growth of man-made emergencies, entailing health and material losses, have been maintained and increased. Therefore, an analysis of the frequency of such events should be used as input for risk management..

Purpose. To analyze technogenic emergencies of the last five years in the territory of the Voronezh region in order to find possible ways to influence the frequency of their occurrence, prevent and minimize the number of human casualties, as well as reduce material damage.

Materials and Methods. Data from the accounting documentation for the five-year period (2017-2021) reflecting qualitative and quantitative characteristics were used. The information was processed by analysing changes in indicators from year to year.

Results. In the course of the work it was found that the most significant from the point of view of medical outcomes are road accidents, which predominate in the structure of man-made emergencies both in the number of accidents and in the number of deaths and injuries. In addition to the importance for the health system, accidents in transport are a serious burden on the economy of the region. Accidents account for 80 per cent of anthropogenic disasters, 18 per cent of fires and 2 per cent of other disasters. Incidents such as the collapse of the bridge, the fall of a helicopter, the explosion of domestic gas, the explosion of a bus, came into the latter category.

Conclusion. The study shows the need for further development and improvement of measures to prevent accidents, due to their most significant health consequences.

Молодежный инновационный вестник. 2023;12(S2):147-149
pages 147-149 views


Rimskiy D.R., Shirobokov N.A.


RELEVANCE. This scientific article will affect the safety of household poisoning. They arise as a result of an acute chemical reaction in the body when exposed to a toxic substance in a certain amount. This leads to an upset of the work of important organs and can pose a threat to life. PURPOSE. This scientific work is aimed at disseminating information about the problem of household poisoning and its discussion not only at the local level, but also among the general public. It also aims to inform people about methods of preventing poisoning in everyday life. MATERIALS AND METHODS. In this study, an analysis of a newsletter from the Office of Rospotrebnadzor in the Voronezh Region was carried out, which provided information on the analysis of the dynamics of household poisoning, including fatal alcohol poisoning, based on social and hygienic monitoring. Statistics from the Office of Rospotrebnadzor in the Voronezh Region on cases of household poisoning for the period from 2019 to 2021 were also processed. Conditions of holding. This work was carried out at the Department of Disaster Medicine and Life Safety of the N.N. Burdenko Voronezh State Medical University. The main result of the study is the conclusions based on the analysis of data on the dynamics of household poisoning, including fatal alcohol poisoning, from 2019 to 2021. CONCLUSION. The conclusion describes the trend of the spread and sale of alcoholic beverages in the Voronezh region.

Молодежный инновационный вестник. 2023;12(S2):149-151
pages 149-151 views


Fedotova E.I., Korovina M.V.


Relevance. The priority direction of modern extreme medicine in our country is the use and development of air ambulance as one of the components of medical evacuation in various emergency situations. The use of air ambulance significantly contributes to reducing the shoulder of medical evacuation, and, accordingly, to reducing the time for making decisions regarding severe victims in various emergency situations.

Purpose: The Voronezh region, due to the large area of the territory, is in urgent need of solving all these problems.

Materials and methods. This paper reflects an attempt to summarize the main directions and problems in the development of sanitary aviation in our region based on the study of medical and sanitary provision in emergency situations in remote areas of the Central Chernozem region.

Results. Our work is based on an analytical analysis of a number of performance indicators of the Voronezh Region State-owned Healthcare Institution "Voronezh Regional Clinical Center for Disaster Medicine" in recent years. This analysis revealed that during the Covid-19 pandemic, the number of requests for medical assistance to the regional clinical center for disaster medicine increased, and, accordingly, the composition of air ambulance significantly increased. The most in-demand specialists who flew to medical organizations of the Voronezh region for 12 months of 2020 - 2022 were anesthesiologists-resuscitators, who made a total of 4,836 departures and departures.

Conclusion. Thus, the air ambulance plays a leading role in the provision of emergency, including specialized medical care.

Молодежный инновационный вестник. 2023;12(S2):152-153
pages 152-153 views


Fominova O.O., Tetushkina A.S.


This article discusses the severity of the burnout syndrome among employees of the disaster medicine center working in conditions of especially dangerous situations that pose a threat to the lives of employees and the people around them. [5] Purpose. The task was to get acquainted with the level of development of the burnout syndrome among employees of the disaster medicine center. Materials and methods. To identify the severity of emotional burnout among specialists, we conducted a survey according to the method of V.V. Boyko. 32 employees of the center were examined. Results. As a result of the survey, out of the total number of surveyed, it was found that burnout syndrome is observed in 21.8%, in the development stage it is 12.5% and there are no signs of the formation of burnout syndrome in 65.6% .Conclusions. A pattern has been revealed that people with a developed burnout syndrome have more than 9 years of work experience in their position. With an increase in work experience in a specialty with hard work in extreme and emergency situations, a burnout syndrome is formed, for the prevention of which it is necessary to carry out rehabilitation measures , psychological support.

Молодежный инновационный вестник. 2023;12(S2):153-155
pages 153-155 views


Tsimbal M.V., Ablaeva A.A., Bikova A.A., Shuklina K.R.



   The relevance of the topic is due to the fact that emergency situations of a biological and social nature in Russia have been and remain important health problems. To date, COVID-19 continues to be one of the most pressing health problems since the end of 2019, which is associated with numerous clinical variants of the course of the Target infection.


   To study and analyze SARS-CoV-2 as a biological emergency.


Materials and methods.


   We conducted an analytical review of the scientific literature on this problem, analysis and selection of the most important information, as well as statistical research methods using data from ROSSTAT, the Ministry of Emergency Situations of Russia and the Operational Headquarters for the new Coronavirus infection.


Keywords: emergency, COVID-19, new coronavirus infection, prevention, anti-epidemic measures.




   From 2019 to 2022, general respiratory morbidity was recorded in the Voronezh Region. During the period taken, 1 662 888 people fell ill with SARS. Registration of COVID-19 cases in the Voronezh Region has been carried out since 2021. In 2021, the total respiratory morbidity was 480,660 people. The diagnosis of a new coronavirus infection was established in 239,057 people (49.7% of the total respiratory morbidity). The number of COVID-19 cases among children under 14 years of age is 15,457 people (6.5% of the total number of cases). In 2022, the number of SARS amounted to 494,947 people. A new coronavirus infection was registered in 314,487 people (63.5% of the total respiratory morbidity). The number of COVID-19 cases among children under 14 years of age is 32,612 people (6.6% of the total number of cases). For the entire period of registration of cases of COVID-19 infection, 21,836,969 cases were confirmed on the territory of the Russian Federation, of which 394,214 deaths. In 2020, there was a trend towards an increase in the number of deaths. In 2021, the increase in mortality reached the maximum mortality for the entire registration period from 2020-2022. In 2022, there was a significant decrease in the number of adverse infection outcomes.




The reason for the decrease in the total number of deaths and the increase in mild clinical forms is primarily due to the mass vaccination of the population, which began in January 2021. 89,423,801 people were fully vaccinated, and the collective immunity is 7.4%. In 2021, immunization against a new coronavirus infection is being carried out in the region, 812997 people received double immunization. Against coronavirus infection, 441487 people received a completed course of immunization in January – November 2022.

Молодежный инновационный вестник. 2023;12(S2):155-157
pages 155-157 views


Chaikina S.V., Zabolotskaya T.I.


Relevance. Among all non-ontogenic lesions of the maxillofacial region, the leading place is occupied by lower jaw fractures and face and neck phlegmon.
Objective: to determine the mechanisms of fractures and phlegmon of the maxillofacial region to select the appropriate treatment tactics.
Materials and methods. Of the 250 patients admitted to the BOKB named after St. Joasaph in May-June 2022, 19 (7.6%) patients with a fracture of the mandible and 58 (23.2%) patients admitted with phlegmon of the maxillofacial region were identified. All patients were examined according to the same schemes: anamnesis collection, palpation of the lesion area, X-ray examinations. Laboratory tests of the blood of patients with phlegmon were performed.
Results. Of all 19 patients with fractures of the mandible, 16 underwent splinting of the jaws, 3 underwent metallosteosynthesis, after interventions these patients were hospitalized from 5 to 8 days, on average 6 days. Surgical treatment was performed in all patients with maxillofacial phlegmon. With phlegmon in one or two areas, the hospital stay averaged 8 days; with deep neck phlegmon, patients were observed in the hospital for an average of 14 days. No fatal cases were observed.
Conclusion. Due to the choice of the correct tactics of diagnosis and treatment, no complications associated with inflammatory processes or concomitant diseases were observed in patients during the study.

Молодежный инновационный вестник. 2023;12(S2):158-159
pages 158-159 views


Shcheglova E.V.


Relevance. The formation of professional competencies among students at the Department of Disaster Medicine and Life Safety using traditional and innovative technologies contributes to the activation of students' cognitive activity on the issues of medical support for the population in emergency situations, but the role of students' adaptation itself is also important for their professional success. Being a complex and resource-intensive process, the adaptation of students not only determines their academic success, personal self-realization and interpersonal relationships, but also sets the pace of their professional development in practical healthcare.

Purpose. The purpose of this study is to analyze the degree of adaptation of students of the same age category to the educational process and to the educational group.

Materials and methods. The test "Adaptation of students in the university" by T.D. was used as a research method. Dubovitskaya, A.V. Krylova, which makes it possible to study the general level of adaptation of senior students to educational activities and the study group, as well as to analyze the cognitive and socio-communicative components in the behavior of students in emergency situations.

Results. The results of the study showed a high level of adaptability of senior students of VSMU. N.N. Burdenko in relation to both educational activities and the educational team.

Conclusions. The analysis of the degree of adaptation is an integral part of the study of the formation of professional competencies among students at the Department of Disaster Medicine and Life Safety. Such indicators as "adaptation to the training group" and "adaptation to educational activities" characterize in detail the degree of communication and cognitive skills of young people on the verge of entering practical health care, and also determine the readiness to carry out their professional activities in emergency situations.

Молодежный инновационный вестник. 2023;12(S2):160-162
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Yurchenko A.S., Tarasov A.S.


Relevance: Reducing child, maternal and infant mortality rates as a result of emergencies is a strategic task of the state.
Purpose: to consider the specifics of medical care, organization and conduct of medical evacuation measures for pregnant women and children affected by emergency situations.
Materials and methods: in the course of the study, the sources of relevant scientific literature were analyzed, as well as a theoretical analysis of data from scientific articles was carried out.
Results: pregnant women and children are the most vulnerable in the event of an emergency. When providing assistance in the disaster area, it is necessary first of all to evacuate pregnant women to a safe place, to calm them down. It is necessary to strive to get the victims to the hospital as soon as possible. Complications often encountered in pregnant women in emergency situations are: increased blood pressure, prenatal discharge of amniotic fluid, anomalies of labor activity, nephropathy. And also often develop conditions that require professional medical care: preeclampsia and eclampsia, premature placental abruption, uterine rupture, bleeding during placenta previa. With an equal degree of defeat, children have an advantage over adults in helping them. First of all, children are evacuated from the hearth, accompanied by relatives, personnel of rescue formations. Children under the age of five are carried out on their hands whenever possible, and as far as possible, sparing types of transportation accompanied by medical personnel are used to evacuate injured children.
Conclusion: The introduction of improved algorithms for providing assistance to pregnant women and children in healthcare, their detailed study in the disciplines of disaster medicine, emergency medicine contribute to the training of qualified medical specialists who will participate in the elimination of the consequences of emergency situations.

Молодежный инновационный вестник. 2023;12(S2):162-164
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Детские инфекционные заболевания


Stefanova Y.A., Skorovarova M.S.


To date, the pandemic of the new coronavirus infection COVID-19 continues with the involvement of the children's population of the globe, including newborns, in epidemic processes. The aim of the study is to analyze the clinical and laboratory features of COVID-19 in infants. There were 44 newborns with a new coronavirus infection COVID-19 who were admitted to the hospital due to perinatal contact with COVID-19 and from intrafamily foci of infection. The main manifestations of the disease were neonatal maladaptation in 63.6% of patients, moderate rhinopharyngitis in 50% of patients, subfebrile fever in 31.8%. Pneumonia (CT-1,2 lesion area) was diagnosed in all who underwent chest CT. It was not accompanied by clinical symptoms of respiratory failure and decreased saturation. The severity was due to metabolic disorders: prolonged retention of elevated values of blood lactate, CPK, LDH, ASAT. There was no increase in DRR.

Молодежный инновационный вестник. 2023;12(S2):165-167
pages 165-167 views

Зуботехническое дело


Burlakowa D.A.


Relevance: In the work of a dental technician, there should always be clarity, uniformity and observance of order, but unfortunately, not always a dental technician can, in the process of work, fulfill these conditions. Non-compliance with cleanliness in the workplace often leads to disruption of the workflow, a decrease in quality and an increase in the production time of prostheses, which often leads to a lack of desire to work and develop in this area.
The purpose of the work: The goal is to improve the work of dental technicians in order to avoid errors.
Materials and methods: To correct this, the 5S system was proposed, which is widely used in many areas of production. It consists of 5 principles: sorting, maintaining order, keeping in order, standardization, improvement. But, of course, nothing can happen without self-control, discipline and teamwork. The most difficult thing in this technique is the development of habits, the observance of cleanliness and order, a person usually needs a lot of time for this.
The results of the study: Thanks to the joint work, the result will be the speed and quality of the manufacture of prostheses, the clarity of all stages.
Conclusion: Most often people have a desire to work in a clean, rationally sorted workplace, since order most often, psychologically, attracts a person and gives a desire to start work

Молодежный инновационный вестник. 2023;12(S2):168-170
pages 168-170 views


Grigorieva A.Y.


Relevance. The significance of this work lies in the fact that the loss of natural teeth is accompanied by a violation of the function of the dental system, diction and a change in the appearance of a person, which has a negative impact on the psyche, mood and behavior of a person. Dental prosthetics helps people to eliminate defects and accompanying psychosomatic disorders, however, prostheses do not always have a positive effect on the psycho-emotional state of the patient. Adaptation to dentures is a complex process of getting used to dentures from the side of psychology and physiology. It is she who is the most difficult stage of dental prosthetics, since not every patient is able to easily get used to a foreign body in the oral cavity. This article examines the impact of dentures on the mental state of people. The problem is urgent, because today an increasing number of people (not only middle-aged and elderly, but also young) resort to dental prosthetics, so it is important to choose such a prosthesis for the patient, so that in addition to replacing the defect and restoring the functions of the dental system, it would also be comfortable for the patient and, importantly, aesthetic for to ensure that the patient does not experience embarrassment and discomfort.
The purpose of the work. Elucidation of the effect of dentures on the mental state of patients of different age groups.
Materials and methods. Conducting a survey. Analysis of the data obtained from 20 patients using a variety of denture designs.
The results of the study. 20 patients were interviewed, of which 10 use removable structures and 10 non-removable ones. According to the survey results, removable plate prostheses have the strongest influence on the psychoemotional state of the patient, and young people are exposed to this effect.
Conclusion. People aged 35 to 50 years are exposed to psychoemotional stress when using prostheses, mainly removable plate ones. Fixed structures of prostheses practically do not cause discomfort in patients, except in rare cases.

Молодежный инновационный вестник. 2023;12(S2):170-172
pages 170-172 views


Ivanina A.S.


Relevance. In orthopedic dentistry, one of the most urgent problems is the restoration of dentition[1]. One of the ways to treat partial and complete absence of teeth is prosthetics using dental implants.
Goal. To study the features of prosthetics with partial and complete adentia using dental implants. One of the main conditions of dental implantation is the proper planning of this procedure, which is the development of an optimal orthopedic treatment plan[2,3].
Materials and methods. The analysis of scientific articles, journals, books on the topic under study was carried out.
Results. According to the principle of its fixation, all structures of prostheses with support on implants can be divided into 3 groups: fixed (fixation is carried out with cement), conditionally removable (screw attachment) and removable prostheses. In the absence of a single tooth, the best solution would be to manufacture a single crown based on an implant[4]. Conditionally removable prosthetics is carried out in the case when only implants are used as a support for a dental prosthesis.
Conclusion. Thus, the study showed that the main advantage of prosthetics based on implants is the preservation of the alveolar ridge and bone tissue, also the load on the jaw joint is evenly distributed and there is a significant improvement in the aesthetic appearance of the patient. These structures are durable and have a high survival rate[5].

Молодежный инновационный вестник. 2023;12(S2):172-175
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Инфекционные болезни и иммунология


Arustamyan A.A., Arinicheva S.A., Shukelait P.A.


Lyme borreliosis (LB) is an infectious natural focal vector–borne disease. Currently, LB remains one of the most common diseases from the group of tick-borne infections. The disease is characterized by polymorphic clinical manifestations and a tendency to a prolonged recurrent course.
For the first time, data on the disease appeared in 1975 in the USA, in the state of Connecticut, the town of Lyme. The first cases of the disease were called juvenile rheumatoid arthritis. Subsequently, it was noted that the disease develops after a tick bite and proceeds in a combination of arthritis and migrating ring-shaped erythema. LB is a ubiquitous disease, found on all continents except Antarctica.
Considering the wide prevalence of LB in Voronezh and the Voronezh region, the polymorphism of clinical manifestations and the tendency to chronic course, knowledge of the features of the clinic and diagnosis of this disease is especially important. The article presents data on the features of the clinical course of LB in the Voronezh region for 2022. The analysis of laboratory data for this pathology is also carried out.
In the Voronezh region, persons 44 ± 13.5 years of age are most often ill with LB, all patients had only an acute manifest erythemic form of the disease with little intoxication. Epidemiological, clinical data and serological diagnostics play a crucial role in the diagnosis of LB.

Молодежный инновационный вестник. 2023;12(S2):176-177
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Zakupnev N.V.


Annotation. A natural focus of ixodic tick-borne borreliosis (ICB) has developed on the territory of the Voronezh Region.The purpose of the study was to assess the epidemic situation of Lyme disease for 2012-2021 and the effectiveness of preventive measures in the region. Materials and methods: with a retrospective epidemiological analysis, data from official sources were studied: reports on sanitary and epidemiological well-being in the Voronezh region, information from the Rosstat form No.2. Results. It has been established that during the studied period, cases of ICD in the region are registered annually, and since 2017 the incidence in the Voronezh region is aligned with those in the country, and over the past 3 years it exceeds the indicators of the Russian Federation. The territorial distribution of cases across municipalities is uneven. Urban residents get sick 2.6 times more often than rural ones, the structure is dominated by the adult population. The appeal of the population about tick bites is increasing, municipal territories with a higher level of registered appeals are noted. According to the results of epizootological monitoring, an increase in the proportion of positive findings of the pathogen RNA in ticks taken from people was noted over the years. The volume of acaricide treatments increased during the studied period, but there was an objective decrease in the areas involved during the period of restrictive measures for COVID-19. Discussion. The incidence in the Voronezh region over the past 3 years exceeds the indicators of the Russian Federation. A higher incidence of ICD among residents of the region's cities is associated with visits to suburban recreational areas or suburban areas, which corresponds to data from other regions of the country. The number of requests for medical help regarding the suction of ticks is lower than in the country. Conclusion: Tick-borne borreliosis is the most common of tick-borne infections registered in the region. There is no correspondence between the increase in the incidence of ICD with an increase in the number of people who have applied for tick bites or suckling. As practical recommendations, in the absence of specific immunoprophylaxis of ICB, the population should be taught proper outdoor recreation

Молодежный инновационный вестник. 2023;12(S2):179-183
pages 179-183 views


Gyulakhmedova A.I., Kaplun A.S.


Relevance.The clinical picture of opisthorchiasis has no specific manifestations characteristic only of this helminthiasis. Symptoms and syndromes are diverse and depend on many factors, which complicates the diagnosis of this disease.
The purpose is to study and analyze the features of clinical manifestations of invasion.
Materials and methods. Medical records of patients diagnosed with acute opisthorchiasis, clinical and epidemiological data, general clinical studies, parasitological and serological studies, ultrasound of the abdominal cavity.
Results. The clinical manifestations of acute opisthorchiasis were analyzed in detail and the main syndromes of the disease were identified. The most informative diagnostic studies have been established – coproovoscopy and blood ELISA with the determination of immunoglobulins G.
Conclusion. The most striking syndromes of opisthorchiasis in the acute stage are dyspeptic, toxic-allergic and asthenovegetative. For the purpose of parasitological confirmation of opisthorchiasis, microscopic examination of the stool is carried out to identify helminth eggs, and also determined
immunoglobulins G in the study of blood by the IF method, the main factor in the transmission of opisthorchiasis is an insufficiently heat-treated fish product.

Молодежный инновационный вестник. 2023;12(S2):178-179
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Korotkova O.M.


Relevance: in patients with diabetes mellitus, infectious diseases, including lesions of the upper respiratory tract, are quite common. It is known that in patients with diabetes mellitus, the damage to the upper respiratory tract is up to 50%, therefore, the relevance of this problem is not disputed.
Purpose: to analyze the composition and characteristics of the microflora from the tonsils in otorhinolaryngological patients with chronic tonsillitis and patients suffering from type II diabetes mellitus with chronic tonsillitis.
Materials and methods: a retrospective comparative analysis of the results of cultures for microflora (pharyngeal swabs) was carried out in patients with chronic tonsillitis and type II diabetes mellitus complicated by chronic tonsillitis. All patients were treated in the otorhinolaryngological and endocrinological departments of the BUZ VO VOKB No. 1. The sample consisted of 28 patients in each group (with and without diabetes).
Results: In otorhinolaryngological patients with chronic tonsillitis, mixed microflora (Staphyllococcus aureus, streptococci, Neisseria, etc.) was most often sown - 40.5%. Staphylococcus aureus was found in 22.1% of cases. And in patients with chronic tonsillitis complicated by type II diabetes mellitus in 12 (43%) patients, Staphyllococcus aureus was isolated in combination with saprophytic microflora (Streptococcus viridans, Streptococcus epidermidis, etc.). Four (14%) patients were diagnosed with Haemophillius influenzae. 3 (11%) patients had Klebsiella pneumoniae, 3 (11%) patients had Staphylococcus epidermidis, and 1 (4%) patient had Escherichia coli. In addition, Candida albicans were cultured in 5 (18%) patients.
Conclusion: Based on the study, it can be concluded that the microflora from the tonsils in patients with type II diabetes mellitus in chronic tonsillitis is the most aggressive, which indicates a decrease in immunological reactivity in these patients. In addition, the prevalence of Staphyllococcus aureus and its high antibiotic resistance are noteworthy. Antibiotic resistance has also been found in Escherichia coli and even in Staphylococcus epidermidis.

Молодежный инновационный вестник. 2023;12(S2):183-184
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Kukushkin V.A., Kartashov I.A.


Relevance: obesity is a pandemic of our time and has significant health consequences, as it increases the risk of developing dangerous chronic diseases: hypertension, type 2 diabetes mellitus, cholelithiasis, as well as atherosclerosis and its complications. The study of the role of the intestinal microbiota in the pathophysiological mechanisms of obesity, as well as the search for new methods of treatment and prevention of this pathology is an urgent task of modern medicine.
Objective: to determine the role of the intestinal microbiota in the development of obesity and to influence its composition with the help of prebiotics and probiotics in order to reduce human weight.
Methods: This study was conducted using PubMed and Google Scholar databases, using the Medical Subject Headers descriptor, without limiting the publication period (with an emphasis on the most recent works). Studies involving animals and obese adults were included. This review did not include obese children, subjects with genetic disorders or autoimmune diseases.
BMI was measured for the selection of overweight patients, the results were recorded.
Bacteriological examination of feces was carried out on the basis of the Lipetsk City Polyclinic No. 4 – and has the character of an open randomized clinical observation. The object of observation: the work included data on 20 patients aged 20 to 60 years with overweight. The exclusion criteria were: taking antibiotics, laxatives and drugs that stain feces.
After dysbiosis was detected, 17 out of 20 overweight patients were prescribed therapy using pre- and probiotics for 21 days. After the study, a control measurement of BMI was performed.
Results: after therapy, body weight decreased by 2-9 kg in 14 patients, body weight remained the same in 1 patient, body weight increased by 2 and 4 kg in 2 patients, respectively. The subjects noted the disappearance of abdominal discomfort, improvement of stool, decrease in blood pressure.
Conclusion: the effect of the gut microbiome on metabolism, hormonal balance, neurotransmitter and brain function may play an important role in weight management and the treatment of obesity. Moreover, the use of probiotics and prebiotics improves the composition of intestinal bacteria and gives promising results in the prevention and treatment of obesity.

Молодежный инновационный вестник. 2023;12(S2):185-186
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Obolenskaya M.A.


Relevance. According to WHO, diseases of the cardiovascular system are the leading cause of death worldwide. Finding the causes of their development is a step towards developing new principles of therapy and reducing the number of deaths.

Goal. To study the role of normal and altered intestinal microbiota in the development of hypertension, atherosclerosis and other cardiovascular diseases.

Methods. Study and analysis of scientific literature.

Results. The scientific literature on the stated topic has been studied, its analysis has been compiled.

Conclusion. The variety of mechanisms of the intestinal microbiota's influence on the human body, its participation in many metabolic, immune, and inflammatory processes indicate the important role of changes in the bacterial composition or in the function of microorganisms in the formation of pathologies of the cardiovascular system.

Молодежный инновационный вестник. 2023;12(S2):187-189
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Astrazhynski Y.A., Kastsou M.A.


The relevance of the study lies in the fact that hemorrhagic fever with renal syndrome (HFRS) is quite widespread in the Republic of Belarus. Viruses that are the etiological agents of HFRS can serve as a trigger for the development of chronic renal failure (CRF) in more than half (57%) of patients in the Republic of Belarus.
The purpose of the study was to analyze clinical and laboratory data for the relationship with the course of HFRS.
Materials and methods of research: the paper analyzed the case histories of 51 patients who were treated at the Minsk City Clinical Infectious Diseases Hospital for the period from 01/01/2017 to 10/18/2022. The study is retrospective, single center, cohort.
Results of the study: among the analyzed patients, men were more often affected by HFRS (74.5% of the entire group). Mostly, HFRS proceeded with moderate severity, but no effect on the length of stay in the hospital and the relationship with antibody titer (AT) were found. Clinical and laboratory dependences in patients with HFRS were analyzed. It was determined that a higher (1:1024 and above) titer of antibodies is not a reliable predictor of a more severe course of HFRS (U = 233, p = 0.080), which, however, requires an expansion of the sample to obtain statistically significant results and further study of diagnostics and treatment of patients with HFRS.
Conclusion: despite the achievements of modern medicine, HFRS remains difficult in the diagnostic search and treatment of a disease with a rather severe course. At the present stage, the most relevant areas for preventing the occurrence of HFRS cases include improving the efficiency of clinical diagnosis and timely conduct of specific laboratory diagnostics for suspected HFRS and optimization of monitoring of HFRS foci in order to develop approaches to predicting the epidemic situation and timely implementation of preventive measures.

Молодежный инновационный вестник. 2023;12(S2):189-191
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Shcheglova E.V., Syromyatnikova M.A.


Relevance: Currently, there is a high incidence of a new coronavirus infection COVID-19, which has influenced the etiological structure of seasonal acute respiratory viral infections.

Purpose: to study the etiological structure of acute respiratory viral infections in children hospitalized in a children's infectious diseases hospital over the past three years.

Methods: In 2020 - 2022 32887 children were examined, hospitalized in the CSTO No. 2 with a diagnosis of ARVI. Of these, it was possible to clarify the etiology of ARVI by PCR in 9673 children (29.4%). Statistical analysis: carried out using the Excel 2008 program.

Results: Analysis of the etiological structure of verified ARVI in children showed that SARS-CoV-2 prevailed in 2020-2022 with a steady increase in the number of new cases from 41.6% -61.9% - 76.2% respectively. In the structure of seasonal acute respiratory viral infections in 2020-2021, the leading positions were occupied by rhinoviruses 206 (20.0%) and 195 (9.2%), respectively, and respiratory syncytial viruses 137 (13.2%) and 164 (7.6%), respectively , influenza viruses 82 (8%) and 134 (6.3%), respectively, were registered less frequently. In 2022, out of 27,143 children examined by PCR, the etiology of ARVI was clarified in 6,504 (24.0%) children. Influenza 414 (6.4%), mainly of group A - H1N1 pandemic, and then rhinoviruses 332 (5.1%) and respiratory syncytial viruses 274 (4.2%) moved to the 2nd place.

Conclusion: In 2020- In 2022, COVID 19 dominated in the etiological structure of updated acute respiratory viral infections in children hospitalized in a children's infectious diseases hospital. At the same time, rhinovirus and respiratory syncytial infections prevailed in the structure of seasonal acute respiratory viral infections in 2020-2021. And in 2022, the pandemic strain of influenza A H1N1.

Молодежный инновационный вестник. 2023;12(S2):192-193
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Иммуновоспалительные заболевания


Malyugin D.A., Shefer A.A., Kovaleva D.M., Ivanenko V.


Relevance. Diabetes mellitus is one of the main socially significant diseases. Recently, the number of publications devoted to the problem of the development of anxiety and depressive disorders in patients with diabetes mellitus has been growing in the scientific literature.

Target. Comparison of the quality of life and psycho-emotional status of patients with diabetes mellitus with healthy people.

Materials and methods. A survey was conducted on a group of patients with type 1 and type 2 diabetes mellitus who were hospitalized in the endocrinology department of the Voronezh City Clinical Emergency Hospital No. 10, as well as a group of healthy individuals (students of Voronezh State Medical University named after N.N. Burdenko). The number of examined in each group was 29 people. The quality of life was assessed using the SF-36 questionnaire, and the psychoemotional status was assessed using the Spielberg-Khanin questionnaire (to identify anxiety disorders) and the Beck scale (to identify depressive disorders). Comparison of the results of the survey of the two groups of surveyed was made using the Mann-Whitney test. In patients with diabetes, the relationship between the severity of manifestations of anxiety and depression and the level of glycated hemoglobin and the standard deviation of blood glucose during the day was assessed (using the Spearman correlation coefficient). The relationship between the severity of disorders and gender, age, type of diabetes mellitus was also assessed.

Results. Patients with diabetes on the background of modern treatment have a lower level of anxiety and depressive disorders, as well as a higher level of assessment of their mental health.

Findings. The results of the study indicate a decrease in the level of depressive and anxiety disorders in patients with diabetes mellitus, against the background of control and modern therapy for this disease.

Молодежный инновационный вестник. 2023;12(S2):194-196
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Shevchenko Y.F., Gorelik S.G., Ilnitsky A.N., Bagdasaryan K.S., Kurganskaya O.N., Maslov K.G.


In this paper, the stiffness index and the augmentation index are presented not only as markers of arterial wall damage, but also as diagnostic markers of dinapenia and sarcopenia in women with arterial hypertension.

The relevance of this work: muscle degeneration is one of the most acute problems of concern to mankind, therefore, the preservation of muscle mass and muscle strength through human involutative processes is increasingly being presented to healthcare and social services.

The aim of our study: to show the role of the stiffness index and the augmentation index in the process of arterial wall remodeling and the development of dina/sarcopenia in women with arterial hypertension.

Materials and methods. The object of the study was 118 women with arterial hypertension of stage II. A photoplethysmographic method was used to determine the stiffness index of the augmentation index, a simple test with a six–minute walk was used to determine the walking distance and walking speed, and hand dynamometry was used to determine the compression strength of the hands.

Results. As a result of the study, it was revealed that with increasing age in women with arterial hypertension, the stiffness index and the augmentation index increase. Prolonged mechanical influence of high blood pressure on the vascular wall leads to a change in its stiffness-elastic properties. And an increase in the stiffness index provokes a violation of metabolic processes in tissues, including muscle tissues. This fact is confirmed by a test with six-minute walking and wrist dynamometry, a decrease in walking speed, muscle strength and the development of dynapenia and sarcopenia.

Conclusions. The stiffness index and the augmentation index appear as diagnostic markers of premature aging in cardiovascular lesions of the arterial wall and the development of geriatric syndromes (dinapenia and sarcopenia).

Молодежный инновационный вестник. 2023;12(S2):197-198
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Клиническая фармакология и фармакоэкономика


Abramyan A.A., Silkin A.V., Klyukin A.A.


Relevance. Antibacterial drugs are an integral component of the complex therapy of purulent-inflammatory diseases in therapeutic and surgical practice. Rational and reasonable use of antimicrobials in most cases affects the effectiveness of the treatment and often determines the outcome of therapy. The combination of factors such as the severity of the patients' condition, the inability in most cases to immediately isolate the pathogens of infection and determine their sensitivity to antibacterial agents makes it impossible to carry out etiotropic treatment at the initial stage. Errors in choosing the means of starting empirical antimicrobial therapy and dosage regimens increase the length of stay of patients in hospitals, aggravate the course of the disease, increase the risk of severe complications with a fatal outcome, lead to an increase in the cost of treatment, as well as an increase in antibiotic resistance.
Goal. To establish the dominant microorganisms in the BUZ VGKBSMP No. 1, to conduct a comparative assessment of antibiotic resistance indicators in the departments provided in 2020 and 2021 for the treatment of COVID-19 patients (2nd surgical, urological and pulmonological) and in the departments that were not directly involved in the treatment of patients with a new coronavirus infection.
Methods. The results of 2,810 bacteriological blood tests performed in 2019 (1,559 studies) and 2022 (1,251 studies) were retrospectively analyzed. The results were processed by the Statistica v.10.0 program.
Results. In the departments that have been repurposed to provide care to COVID-19 patients, there is a predominance of polyresistant flora (MDR), which has shown an increase in resistance to cephalosporins of the third generation, respiratory fluoroquinolones and aminoglycosides of the third generation, which is a negative trend. There is no similar increase in antibiotic resistance in departments that did not directly help patients with COVID-19.
Conclusion. Thus, the use of antibiotics significantly improves the prognosis of patients with purulent-inflammatory diseases, and on the other hand, negatively affects the life of society as a whole, brings huge social and economic losses associated with preventing the spread of infections caused by resistant microorganisms.

Молодежный инновационный вестник. 2023;12(S2):199-202
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Andreev I.A.


Relevance: According to clinical guidelines, JRA is a frequent disease leading to a high percentage of disability and even death. Since the end of the twentieth century, GEBS has been actively used in our country. Questions of efficacy and safety of this therapy in children require additional study.

Purpose: To evaluate efficacy and safety of GEBS use in patients with rheumatoid arthritis.

Material and Methods: A retrospective analysis of the documentation of 50 children with JRA aged 3 to 17 years who were treated in the cardiology department of the Children's Clinical Hospital at "VSMU named after N.N. Burdenko" during the period from 2019 to 2022 was performed. Mean age of patients was 11.22±3.62 years. The sex ratio (M:G) was 1:3,54.Low and moderate activity was noted in 46 children (92%), high activity - in 4 children (8%). Duration was 1 to 10 years (3.6±1.2 years). Twenty-one patients (42%) were admitted at the acute stage. Fifteen of them had polyarthricular form (7 of them had seropositive and 3 - HLA-B27-associated RA). In 31, the oligoartricular forms (3 were seropositive, 2 were ANA- and HLA-B27-associated and 1 was ANA-associated only).Therapy before GEBS: 47 children (94%) had methotrexate, 3 (6%) had methylprednisolone. A group of patients with exacerbation of JRA (n=21) was formed from the sample and divided into 3 subgroups depending on the degree of process activity: 1 degree (n=3), 2 degree (n=15) and 3 degree (n=3). To objectivize the results of patients' treatment in the acute stage the index of medical effectiveness was used. Assessment of safety of drugs was reduced to the account of marked changes in the results of clinical and laboratory examination, adverse reactions in response to the administration of drugs. In the study only noted complications directly in the hospital were taken into account without considering in the statistics reactions to GEBS before admission.

Results: In all patients the efficacy of the therapy - cessation of further disease progression - was registered. The appearance of psoriatic rash elements was observed in 1 patient during the use of etanercept. In another 1 patient against the background of tocilizumab treatment, formation of ulcers in the oral cavity was noted. Complications made up 4% and didn't recur after the change of drugs.

Conclusion: GEBS therapy is an effective and safe method of JRA treatment. Unfortunately, remission is difficult to achieve in children with a high degree of active JRA, but treatment with GEBS can significantly reduce clinical manifestations. Timely monitoring of possible complications and evaluation of treatment efficacy are important.

Молодежный инновационный вестник. 2023;12(S2):202-204
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Arustamyan A.A.


Cardiotoxicity of chemotherapeutic drugs is one of the serious complications of drug treatment of malignant neoplasms, since it can create conditions for the formation of myocardial dysfunction. One of the widely used drugs in oncology with cardiotoxic effect is doxorubicin (synonym - adriablastin). The incidence of various cardiac complications in patients taking doxorubicin reaches 36%.

Молодежный инновационный вестник. 2023;12(S2):204-206
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Arustamyan A.A., Arinicheva S.A.


Relevance: Lyme disease is one of the most common natural focal vector-borne infections. According to Rospotrebnadzor, over the past 5 years, there has been a trend towards an increase in the incidence in the Voronezh region.

The relevance of timely treatment is based on the high probability of chronicity of the process, the development of severe complications in the absence of adequate pharmacotherapy.

The aim of the work is to study the features of the course and the effectiveness of the ongoing pharmacotherapy intended for the treatment of patients with Lyme disease.

The study was conducted retrospectively based on the analysis of case histories for 2022. A total of 50 case histories of patients with Lyme disease aged 18 to 69 years were analyzed. Of these, 19 men, 31 women.

Results. The choice of the product depended on a number of reasons, for example, extracutaneous manifestations (arthralgia, disorders of the nervous system and cardiac activity, etc.). In 100% of cases, a favorable effect of the prescribed therapy. As was found in the course of a retrospective study of case histories, at present the disease has a latent course and is detected incidentally - based on the fact of a tick bite, when erythema migrans is detected. Timely healing helps to avoid adverse consequences.

Молодежный инновационный вестник. 2023;12(S2):206-208
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Лучевая и функциональная диагностика


Alvane K.H., Aleksahina M.A.


Relevance. The liver is the largest organ of the abdominal cavity, which occupies most of the right hypochondrium and epigastric region, often enters the left hypochondrium to the left lateral line. Segmental anatomy of the liver is well studied by both surgeons and radiologists. However, few studies are devoted to the superficial variant anatomy of the liver. Knowledge of the normal and variant anatomy of the liver is important both for radiological examination and surgical intervention, and for diagnosis in urgent surgery for blunt abdominal injuries.

Goal. To determine the diagnostic significance of sonography and computed tomography for visualizing the features of the anatomical structure of the liver in children, as well as the features of the ultrasound picture of the elongated left lobe of the liver (saddle liver).

Materials and methods. The data of two clinical cases of structural features of the left lobe of the liver in adolescent girls aged 13 years were studied during a routine ultrasound examination of the abdominal cavity organs at the Children's Doctor Medical Center in Voronezh.

Results. During the planned ultrasound examination of the abdominal organs in the medical center "Detsky Doktor" Voronezh, according to the appointment of a gastroenterologist with a difference of 2 years, two cases of structural features of the left lobe of the liver in adolescent girls of 13 years were revealed. Only in one case, a follow–up examination (CT of the abdominal organs) was carried out and the results were provided – a feature of the structure of the left lobe of the liver was confirmed – an increase in size (a variant of development - a "saber-shaped" liver).

Conclusion. The study of anatomical features of the liver is important for modern practical medicine. Knowledge of the variant anatomy of the left lobe of the liver is important both for ultrasonologists and radiologists, especially when using the FAST protocol for blunt abdominal trauma to search for the presence or absence of hemoperitoneum, and for surgeons when planning and performing surgical interventions on the liver in order to prevent a possible misdiagnosis.

Молодежный инновационный вестник. 2023;12(S2):209-212
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G. N.O., K. S.


Introduction: Magnetic resonance imaging (MRI) is the most modern non-invasive method that provides the possibility of obtaining high-resolution spatial visualization. Gadolinium contrast compounds have been used for more than 30 years and are currently leading in the field of MRI research. However, modern studies show that gadolinium is able to accumulate in brain tissues with repeated injections and remain there for many years, and is also contraindicated in persons with severe renal insufficiency, as it can lead to severe complications, such as nephrogenic systemic fibrosis. That is why at the present stage, numerous works are being carried out in the field of creating a more accurate and safe replacement for toxic gadolinium substances based on manganese oxide nanoparticles.
Objective: To conclude, based on the analysis of currently available studies, whether manganese CA are an effective and safer replacement for gadolinium CA used in most studies. To compare the contrast enhancement obtained using manganese-based contrast agents in identical clinical models with gadolinium analogues, to evaluate the pharmacinetics and metabolism of both types of drugs.

Materials and methods: The analysis of articles in three foreign clinical databases, which appeared in the period from 2018 to 2022, was carried out. The results of dynamic visualization of Mn-PyC3A and Gd-DTPA were used to control the distribution and excretion of both substances administered to rodents. To control the pharmacinetics, data from identical clinical models were compared. The study of the absorption activity of manganese by ischemic areas of the myocardium was evaluated, as well as a comparison of the quantitative assessment of the area of myocardial infarction made between MnDPDP and gadolinium analog.

Results: A rodent study showed that a week after the administration of a dose of Mn-PyC3A, the percentage of residual manganese in the body (0.058 ± 0.051) was less than the percentage of residual gadolinium (0.19 ± 0.052). Evaluation of Mn-PyC3A metabolism shows that the substance was rapidly excreted from the body both through the kidneys and through the liver. Renal-hepatobiliary clearance for 24 hours was 99%. In the study of the area of myocardial infarction, MnDPDP showed a more accurate result, due to the ability to easily pass through calcium channels, similar to calcium, unlike Gd-DTPA, which dramatically overestimated the size of the infarction, capturing the unchanged part of the myocardium. When evaluating the contrast gain, Mn-PyC3A showed a result approximately identical to the gadolinium analog. Data on the safety of manganese products require further research, but currently surpass gadolinium analogues not only in terms of toxicity, but also the risk of complications.

Conclusion: In the study of pharmacinetics and metabolism, manganese contrast agents are superior to gadolinium-based analogues. In the study of the area of myocardial infarction, the results after injection of MnDPDP were significantly more accurate than the results after injection of Gd-DTPA on an identical clinical model. At the moment, researchers have yet to assess the potential cardiotoxicity of manganese, due to the ability to displace calcium from healthy cardiomyocytes in the study of ischemic areas of the heart muscle, as well as to select a chelate compound of sufficient strength to prevent a possible negative relationship with cells and proteins, but already research data allow us to conclude that manganese contrast enhancers are comparatively safer., in contrast to gadolinium derivatives.

Молодежный инновационный вестник. 2023;12(S2):212-213
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Seqdalieva K.L.


Annotation. Relevance. Trends of recent decades demonstrate an increase in the number of patients with mechanical jaundice syndrome (MJ) The problem of diagnosis and treatment of diseases accompanied by MJ syndrome remains an urgent medical and social problem. The issues of timely and rational therapeutic tactics for MH are still far from being resolved. Goal. The study of the role and place of radiation methods in the therapeutic and diagnostic algorithm and its improvement taking into account possible complications. Methods. The analysis of the results of treatment of 868 patients with MJ who were treated at the bases of the general surgery clinic "DSMU" for the period from 2000 to the present was carried out.The results are statistically processed using the Statistica 6.0 Results program. In 216 cases, cholecystolithiasis was the cause of mechanical jaundice. According to ultrasound data, proximal obstruction was detected in 142 cases, central obstruction in 256 cases, and distal obstruction in 470 cases. Conclusion.Repeated ultrasound at the stage of diagnosis of obstructive diseases of GPDD has low information content. An increase in the number of diagnostic measures leads to an extension of the terms of diagnosis and diagnosis and, accordingly, to an increase in the duration of hospitalization of the patient. Performing MRCG at the early stages of the diagnosis of obstructive diseases leads to a reduction in the duration of inpatient treatment of patients by 3-5 days.

Молодежный инновационный вестник. 2023;12(S2):215-217
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Elfimov A.D., Guseva S.A.


Relevance:The number of appeals related to diseases of the cardiovascular system annually occupies a leading position, mainly atherosclerosis. Modern vascular examination technologies make it possible to identify problems at an early stage, predict risks and correctly prescribe a method of treatment. The best method diagnostic of atherosclerosis is multispiral computed tomography angiography.

Objective: To identify the relationship of patients' complaints with the localization of atherosclerotic vascular lesions using computed tomographic angiography. To make forecasts of the risk of acute conditions against the background of occlusion of the lumen of the arteries.

Materials and methods: A comparative analysis of complaints from the cardiovascular system and data from 30 computed tomographic angiographs of patients with pathologies of atherosclerotic genesis was performed. Forecasts of the risk of developing cardiac complications using calcium-scoring by the Agatston method are given.

Results: From the presented sample, most of the patients, namely 53% (group A) complained of sharp pains in the heart, behind the sternum, angina attacks according to MSCT angiography, single or multiple atherosclerotic plaques in the lumen of the coronary arteries were detected in all patients of group A. In 16.67% of patients (group B) with complaints of dizziness, shortness of breath, pain in the distal parts of the extremities, no pathologies of atherosclerotic genesis were detected on MSCT angiography. Group B, which made up 13.33%, received complaints of pain in the lower extremities, intermittent lameness, low skin temperature in this area, in all cases, atherosclerotic changes in the vessels of the femoral artery basin were detected during angiography. 10% (group D) complained of pain in the meso- and hypogastric areas, the occurrence of constipation, with contrast examination of the mesenteric arteries in various areas, plaques were found. 6.67% (group D) complained of memory loss, severe headaches according to MSCT angiography, atherosclerosis of the brachiocephalic arteries was determined.

Conclusions: During the study and analysis of computed tomographic angiography data, 5 groups of patients with relevant complaints were identified, of which the overwhelming majority (53%) suffer from atherosclerosis of the coronary arteries (43.75% have a high cardiovascular risk), 13.33% account for atherosclerotic changes in the arteries of the lower extremities, 10% of the total number are occupied by mesenteric plaques vessels, 6.67% - brachiocephalic arteries, no pathologies of atherosclerotic genesis were detected in 16.67% of the treated patients.

Молодежный инновационный вестник. 2023;12(S2):213-215
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Soloveva A.A., Popov Y.V., Porotkova O.V.


Relevance. Multiple myeloma (MM) is a malignant lymphoproliferative disease, the morphological substrate of which is plasmotic cells secreting monoclonal immunoglobulin [1]. The pathology described above is 13% among hematopoietic tumors, this indicator indicates a high incidence. And, although the clinical picture of multiple myeloma is well known, doctors often face diagnostic difficulties. The key diagnostic method is classical radiography as the main method of morphological visualization of MM manifestations, pathological changes in bones[3]. Goal. To evaluate the significance of X-ray examination of bones in patients with multiple myeloma at various stages of follow-up. Materials and methods. The study was conducted on the basis of the Department of Instrumental Diagnostics of the Burdenko State Medical University. The data of the patient's X-ray examination, as well as morphological and immunohistochemical examination of the biopsy material, computed tomography (CT), positron emission tomography (PET-CT), magnetic resonance imaging of the lumbosacral region (MRI) were studied. Results. The paper presents a clinical case of multiple myeloma in a 54-year-old woman. The observation period is from December 2021 to May 2022. Doctors suspected a pathological fracture, the patient was sent to an oncological dispensary. According to the results of histological and immunohistochemical studies of the biopsy material, the patient was diagnosed with multiple myeloma, unclassifying form, osteodestructive syndrome with soft tissue components. At the time of the beginning of polychemotherapy (PCT) according to the VCD program, on the radiograph of the left humerus, the patient has a 10x4 cm destruction site, as well as areas of discharge in the proximal humerus. The patient underwent 3 courses of PCT, against which she notes an improvement in the form of a decrease in the intensity of pain syndrome and a decrease in the need for analgesics. Positive dynamics is observed on the control radiograph, namely the consolidation of the fracture. Conclusion. Despite the emergence of new methods for the diagnosis of oncological diseases (CT, MRI), X-ray diagnostics, today, remains not only informative, but also the most accessible option, both for primary diagnosis and monitoring of the dynamics of the tumor process, and for monitoring the treatment of patients with multiple myeloma.

Молодежный инновационный вестник. 2023;12(S2):217-219
pages 217-219 views


Trishina S.D., Andreeva A.A., Chernicyn K.I.


Relevance. Ovarian cancer is the fifth leading cause of death among women worldwide. Patients are known to have a very poor prognosis. In this regard, the diagnosis of ovarian carcinoma at the stage of cystitis is part of the difficult and demanding treatment. As a result, a decrease in the death rate and an increase in life expectancy.

Objective: to study the possibilities and importance of PET-CT in the diagnosis of ovarian cancer in comparison with other methods of visualization of malignant neoplasms. Evaluate the advantages and disadvantages of this method.

Methods: a literature search was conducted on the etiology, epidemiology, classification and clinical picture of ovariocarcinomas. The search was also conducted on the latest updates and advances in ovarian cancer imaging, including PET-CT.

Results: Ovarian cancer is one of the types of gynecological cancer that is detected all over the world. In the structure of oncological diseases among the female population of Russia, he ranks 9th. The exact cause of ovariocarcinomas is unknown. Currently, the stage is determined based on the classification of FIGO (2014) and TNM. Diagnosis using PET-CT with 18-FDG has the greatest effectiveness and visualization of pathological processes in the ovaries with an increase in the level of protein-antigen CA-125 in the blood serum, as well as inaccurate and insufficient data as a result of CT or MRI studies. The maximum standardized absorption value using F-18 FDG PET-CT showed high diagnostic accuracy for differentiating epithelial ovarian cancer from benign pelvic tumors, including ovarian cancer at an early stage. But there is a need to refine the correct interpretation of the results of PET-CT with 18-FDG and integrate this method as a treatment planning aid.

Conclusion: ovarian cancer is one of the most common malignant neoplasms in the world with significant morbidity and mortality. Advances in imaging are aimed at early detection, accurate stage determination, early relapse detection and lesion detection. PET-CT with 18-FDG is one of the most modern and high-quality methods in the diagnosis of ovariocarcinomas, allows to improve the process of early detection of the disease and establish the necessary treatment plan. However, this instrumental diagnostic method requires refinement and improvement of the interpretation of the results, since there are cases of inaccurate tracing and clarification of complex clinical cases, which can lead to an acceleration of the development of the pathological process due to incorrectly initiated or not initiated treatment.

Молодежный инновационный вестник. 2023;12(S2):219-221
pages 219-221 views



Akulinin D.A., Spitsin I.R.


Relevance: Nowadays, the theory that the gut microbiome affects not only the physiological, but also the mental state of the host's organism, is increasingly being confirmed.

There have been carried out many clinical trials that suggest a connection between pathological conditions and the composition of the intestinal microbiota.The basis of this connection is neurotransmitters and other substances produced by representatives of the normal or altered intestinal microbiota and capable of influencing the course of the disease.

Such relationship is observed in autism spectrum disorders (ASD), which represent a group of biological disorders associated with metabolic disorders. While monitoring the patients with ASD it was noted that many of them had gastrointestinal (GI) symptoms (abdominal pain, constipation, diarrhea, etc.), correlating with worsening of psychological symptoms of ASD.In such patients, there was an increase in anxiety, irritability, and isolation compared to children without GI disorders, which, apparently, is caused by quantitative and qualitative disturbances in the composition of the intestinal microbiota.

Every year the incidence of autism is increasing, and in this connection there is a need for a more detailed study of the pathogenesis of this disease.                       

Objective: To investigate the relationship between changes in the gut microflora producing short-chain fatty acids (SCFAs) and symptoms of ASD.                 

Materials and methods: A number of sources of native and foreign literature on the basis of the Pubmed and CyberLeninka database were analyzed.         

Results: It was found that the shift in the intestinal microflora affects the manifestations of ASD through changes in the concentration of SCFAs.                                                                  

Conclusion: A large number of trials of the composition of the microbiota in ASD and changes in the concentration of SCFAs produced by it have proven scientific interest and the perspectiveof further study of this question.Confirmation of the proposed pathogenetic chains can become the basis for the development of a new direction in the pharmacotherapy of ASD, which confirms the relevance of the considered problem.

Молодежный инновационный вестник. 2023;12(S2):222-224
pages 222-224 views


Aralova V.S.


According to the World Health Organization, gastritis occurs in 60% of the population. The main cause of this disease is infection with the H.pylori bacterium, which is registered in 80-90% of cases. A number of other factors also affect gastritis, such as lifestyle, diet and predisposition to the development of this disease. In some people, the bacterium may not manifest itself for a long time, while in others it begins to multiply rapidly and destroy the gastric mucosa. It is worth highlighting that Helicobacter pylori is capable of causing not only chronic gastritis, but also pathologies such as peptic ulcer, adenocarcinoma, MALT lymphoma.
Goal. To evaluate the pathomorphological features of gastritis associated and not associated with H.pylori. In addition, take into account the role of tryptase TC in the formation of the inflammatory process.
Materials and methods. The analysis of biopsy materials, conclusions of pathologists in patients diagnosed with gastritis for the presence of Helicobacter pylori infection was carried out on the basis of the Voronezh Regional Pathology Bureau for the period 2017-2022. The morphological characteristics were evaluated using survey microscopy, an immunohistochemical method aimed at determining the presence of isolated tryptase and H. pylori and multiple immunofluorescence labeling, which allows identifying two antigens on one slice - tryptase TK and H. pylori.
Results. The OLGA international system (Operational Link on Gastritis Assessment) was used to assess inflammation in chronic gastritis, with the help of which the degree of inflammation and the stage of atrophy were determined.
Conclusion. The participation of H. pylori is often associated with the development of inflammation of the gastric mucosa, but in addition to this bacterium, immunocompetent cells also play a significant role.

Молодежный инновационный вестник. 2023;12(S2):224-226
pages 224-226 views


Enenkov N.V.


Relevance. Currently, various stimulators of skin wound regeneration are being actively studied, among which aloe extract is of interest. Literature data show that this compound enhances angiogenesis, however, this effect is little studied in relation to a skin wound.

Purpose: to study the effect of aloe extract on the vessels of the microvasculature during skin wound healing.

Materials and methods. The study was performed on 18 guinea pigs. Animals were modeled with a 20x20 mm wound. After euthanasia, material was taken for histological examination on days 7, 14, and 21. Then, histological sections were made and stained with hematoxylin-eosin. Ten fields of vision were evaluated at a magnification of 400, the total number of vessels and their average area were determined. Statistical data processing was carried out using the Mann-Whitney test at р˂0.05.

Results. It was found that on the 7th day there were no statistically significant differences. On day 14, in the group using aloe extract, the total number of vessels was 7.79% more than in the control group (p˂0.05). There is also a statistically significant increase in the average vascular area in the aloe extract group versus the control group by 91%. On the 21st day of experimental skin wound healing, it was found that the total number of vessels in the microcirculatory bed under the conditions of using aloe extract was 88.24% more than with spontaneous wound healing (р˂0.05). The mean vascular area is also larger in the aloe extract group by 14.29% than in the control group (p˂0.05).

Conclusion. Morphological analysis of the vessels of the skin wound showed that aloe extract has an effect on the processes of angiogenesis, as evidenced by an increased number of blood vessels on all days of the experiment.

Молодежный инновационный вестник. 2023;12(S2):226-228
pages 226-228 views


Kuzeiv I.J., Khalilova G.R.


Relevance.  According to the World Health Organization, up to 300,000 people die every year from cancer in Russia.  One of the oncological diseases is multiple myeloma (MM) Gk and Ben-Jones, which is quite rare, according to statistics, it affects 2-4 people per 100,000.
Target.  To study the pathoanatomical features of MM Gk and Ben-Jones, to conduct a retrospective analysis of the frequency of occurrence of MM Gk and Ben-Jones in the Tambov region for the period from January 1, 2022 to November 5, 2022.
Materials and research methods.  The study was conducted on a specific Patient whose main disease was multiple myeloma Gk and Ben-Jones.  At autopsy, structural changes were observed in such organs as the liver, kidneys, lungs, in the bone marrow of flat and tubular bones, the spleen and heart.  During the histological examination, structural changes were observed in these organs.
Discussion.  Multiple myeloma Gk and Ben-Jones is a malignant plasma cell tumor that produces monoclonal immunoglobulins that invade bone tissue and destroy it.  One of the characteristic manifestations is a lytic lesion of the bones.  For diagnosis, M-protein and an excess number of plasma cells in the bone marrow are detected.  M-protein belongs to IgG in 55% of patients, to IgA - in 20% of patients.  Among patients producing IgG or IgA, 40% have Bence-Jones proteinuria, in which free monoclonal kappa or lambda light chains are found in the urine.  M protein is rarely seen in blood and urine, but modern light chain assays have been able to detect monoclonal light chains in the serum of many of these formerly so-called non-secretory patients.
Results.  A retrospective analysis of data on the number of neoplasms for the period from January 1, 2022 to October 5, 2022 shows that the total number of patients with neoplasms was 1613 people.  Malignant neoplasms (MN) of the hematopoietic system affect 145 people, which accounted for 8.9% of the total number of patients.  Multiple myeloma Gk and Ben-Jones were diagnosed in 41 people - this is 28.2% of all patients with MN of the hematopoietic system and 2.5% of the total number of patients with neoplasms.
Conclusion.  Multiple myeloma Gk and Ben-Jones is a complex pathological process that is quite rare, but poses a serious threat to life.

Молодежный инновационный вестник. 2023;12(S2):228-230
pages 228-230 views


Kutsova M.V., Klimets A.G., Chupandina E.E., Enkova E.V., Filin A.A.


Premature birth remains one of the most important and main problems of obstetrics and gynecology. There is a lot of data on the pathogenesis of abortive pregnancy, however, for a more detailed understanding of the pathological process, it is necessary to study local mechanisms at the cellular and tissue level. Of great interest is the participation of M1 and M2 macrophages in inflammatory and immunological processes in the structure of the placenta. The use of the obtained data will prevent the development of the pathological process during pregnancy.
The aim of the work is a morphological, histological, immunohistochemical study of the placental biomaterial in preterm labor.
A comprehensive morphological examination of placentas was carried out, which consisted of: macroscopic description, organometry, overview histology and immunohistochemistry. To study the placenta at various levels of structural organization, the material was fixed in 10% neutral formalin. Sections for immunohistochemical and histochemical staining were made from the studied placental tissue samples. A total of 20 placentas were examined. 20 blocks were made, 3 slices were made from each block: 2 slices of 1 micron and 1 slice of 5 microns. Placentas were divided into two groups: the first included placentas from childbirth with prenatal outpouring of amniotic fluid, the second group included placentas with premature birth, provided the amniotic fluid was preserved. The first group was divided into three subgroups (1a, 1b, 1b) depending on the gestation period. Immunohistochemical method revealed CD-68+ and CD-163+ macrophages, which were identified using rabbit monoclonal antibodies. The stained micro-preparations were studied on a hardware and software complex for biological research based on a direct research microscope ZEISS Axio Imager A2. The information received was processed using ZEN 2.3 software.
As a result of the work, it was revealed that the indicators of CD-163 positive macrophages (M2) are high in all the studied placenta groups. The average total number of 25 visual fields: subgroup 1a - 494.25, subgroup 1b - 318.34, subgroup 1b -402, group 2 -395.5. The indicators of CD-68 positive macrophages (M1) are higher in the groups of pregnant women with prenatal outpouring of amniotic fluid (group 1). The average total number of 25 visual fields: subgroup 1a - 67.5, subgroup 1b – 86, subgroup 1b - 145.67, group 2 – 44.
According to the results of the study, it was concluded that M1 and M2 macrophages are actively involved in immunomorphological processes in the placenta during premature birth.

Молодежный инновационный вестник. 2023;12(S2):230-232
pages 230-232 views


Nefedova D.S., Frolov A.Y., Razenkov I.A.


The relevance of this work lies in the consideration of specific histopathology scales that can be used to improve treatment outcomes in patients with tendon rupture.

The aim of the study is to evaluate tendon histopathology scales in order to select the best and convenient option for specialists.

The study revealed that many authors distinguish two main scales Movin and Bonar, which have high performance and statistical validity and are most often used in experimental work. For each study, different parameters were used and a comparative characterization was carried out.

The results showed that sonography showed no signs of tendopathy in most cases. Which was not consistent with the results of histological evaluation using a semi-quantitative scale, where changes were detected in a larger number of specimens. These indices tell us about a better assessment of tendon tenopathy at the cellular level.

Therefore, it should be noted that microscopy can focus on the fact that the injected antispasmodic drug has a negative or even toxic effect on the tendon tissue, the new suture causes impaired trophicity in the sutured edges of the tendon, despite high tensile strength values. Which makes a significant contribution to improved patient care.

Молодежный инновационный вестник. 2023;12(S2):232-233
pages 232-233 views


Petrovskaya M.A.


The morphological features of the skin of rats under burn exposure under conditions of spontaneous healing and as a result of the use of ointment with a new derivative of N-acetyl-6-aminohexanoic acid were studied. The aim of the work is to study the effect of a new derivative of N–acetyl-6-aminohexanoic acid on the reparative processes of rat skin during experimental thermal burn. Material and methods. The object of the study was 50 laboratory nonlinear female rats weighing 140-160 g, of which 45 were simulated thermal burn using a steel stencil. From the first day and throughout the experiment, the animals of the experimental group were corrected for burn healing by applying 2% ointment with N-acetyl-6-aminohexanoic acid–2-ethyl-6-methyl-3-hydroxypyridinium N-acetyl-6-aminohexanoate.
Results. During the experiment, it was found that in the rats of the experimental group, the regeneration of burn wounds took place at an earlier time against the background of a lower level of C-reactive protein, in contrast to the comparison groups. Conclusion. The analysis of the results of experimental studies allowed us to establish the stimulating effect of applying ointment with a new derivative of N-acetyl-6-aminohexanoic acid.

Молодежный инновационный вестник. 2023;12(S2):234-236
pages 234-236 views



Korneeva V.V., Guseva P.M.


Currently, there are about 8000 hereditary diseases and about 800 of them are accompanied by symptomatic epilepsy. It is very important to diagnose these diseases as early as possible, as this allows you to prescribe adequate specific therapy in a timely manner and avoid severe clinical manifestations. Biotinidase deficiency, which belongs to the group of hereditary metabolic diseases, is a serious violation, because. the lack of this enzyme leads to a deficiency of free biotin, which is involved in key metabolic reactions as a coenzyme of carboxylase. This causes the presence in the clinical picture of both skin manifestations (rashes, alopecia as a result of a metabolic disorder of fatty acids), and neurological symptoms due to local lactic acidosis. The clinical picture usually appears in infancy, less often in puberty. Its severity is determined by the degree of activity of the biotinidase enzyme. With delayed diagnosis, the disease progresses rapidly, which can lead to death. However, a correct diagnosis and the beginning of adequate therapy can not only stop the further development of the disease, but also reverse the clinical picture.

Purpose: to analyze the key points of pathogenesis, the clinical picture of biotinidase deficiency and the effectiveness of pathogenetic therapy with biotin.

Materials and methods. Study and analysis of literature on various aspects of biotinidase deficiency.

Results. Detection in a patient in the first six months of life of seizures resistant to therapy with antiepileptic drugs, various skin changes, alopecia, and psychomotor developmental disorders suggests biotinidase deficiency, a pathology from the NBO group. The intake of free biotin at a dosage of 10–30 mg/day contributes to the involution of all clinical conditions: the disappearance of seizures, the restoration of hairline, and the normalization of acid-base balance. A timely diagnosis and the appointment of pathogenetic therapy determine the severity of the clinic and the outcome of the disease.

Молодежный инновационный вестник. 2023;12(S2):237-239
pages 237-239 views


Muradova A.S.


Relevance. Every year, a large number of cases of stroke in people of different ages are registered in the world. Moreover, one of the severe complications that can occur after this disease is epilepsy.
Materials and methods. The study was conducted on the basis of the neurovascular department of VOCB No.1. The study included patients with ONMC and paroxysmal conditions of unspecified genesis, such as respiratory disorders, fluctuation of consciousness, various motor phenomena. All patients underwent neurological examination, EEG, CT GM, ECG, laboratory research methods, as well as analysis of data obtained when working with archival material.
Results. In the course of the study, the most frequent localization of the focus of stroke was established, the age category that is more likely to experience complications after stroke, characteristic changes in this pathology on CT GM, EEG, with consideration of the localization of lesions in these methods of research, the presence ofThere was a certain pattern of localization of these foci in both research methods, and the question of the most favorable prognosis in different groups of patients was also considered. Conclusion. Based on the analysis, it was found that EEG remains a highly informative way to assess the functional state of the brain. Of great importance is the analysis of the basic rhythm, its reactivity, the obtained data of which can help in interpreting the severity of the patient's condition, determining the further prognosis.

Молодежный инновационный вестник. 2023;12(S2):239-241
pages 239-241 views


Khripushin N.A.


Relevance: The topic of the influence of the human microbiota on the course of multiple sclerosis is extremely relevant for the medical community. Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that affects numerous human functions, such as movement, vision, sensitivity, emotional state and cognitive functions. Multiple sclerosis is a chronic neurological disease that progresses over time and often leads to severe disability. Despite the fact that for many years research in this area has been aimed at studying the genetic and environmental factors that affect the development of multiple sclerosis, we still do not know much about the other mechanisms that are behind the development of this disease.

Objective: to analyze the state and composition of the human microbiome with a different course of multiple sclerosis and the dependence of the progression of cognitive impairment.

Materials and methods.A comparative analysis of clinical data, general clinical laboratory studies in patients of two groups was carried out: the first – control (healthy people), the second – patients with multiple sclerosis and an increased value of Alistipes and the third group - patients with multiple sclerosis and an increased value of Alistipes and Bacteroides vulgatus.

Results: The analysis of the state and composition of the microbiome of patients with multiple sclerosis was carried out and the ratio of microorganisms and their influence on the progression of cognitive functions was revealed.

Conclusion: It was revealed that in patients with multiple sclerosis, the microorganisms Alistipes and Bacteroides vulgatus are at an increased value than in the control group, which indicates a direct dependence of the progression of cognitive impairment on the composition of the human microbiome.


Молодежный инновационный вестник. 2023;12(S2):241-242
pages 241-242 views



Babenko Y.D., Dimitrova E.G.


Relevance. Bladder cancer is one of the most common diseases of oncourology. therefore, it is necessary to raise the level of awareness of doctors on this topic. For several decades, the gold standard of treatment for this pathology has been minimally invasive surgical intervention-transurethral resection (TUR) of the bladder.
The purpose of the study. Based on the analysis of medical histories, to identify the main clinical and morphological parameters that allow predicting the development of recurrence of bladder cancer after its surgical treatment.
Material and methods of research. A retrospective analysis of the case histories of 479 patients with RMP who received surgical treatment in the urological department No. 2 of the "VOKB No. 1" for the period 2020-2022 was carried out. The results of the study were statistically processed using standard methods of variational statistics using the MicrosoftExcel 2019 program. In addition, the study used materials from scientific publications on this topic, reflecting the causes and mechanisms of bladder cancer development.

Results.When analyzing the case histories, certain patterns of the course of the disease were identified, which will be discussed in this article. Some of them: men get sick more often than women, and the average age is 68 years. During cystoscopy, an average of 2 tumors are detected, their most frequent localization is the posterior wall of the bladder. After analyzing histological studies, a conclusion was made about the most frequent cellular structure. This allows you to choose further treatment tactics. In more complex cases, radical cystectomy is used. Special attention should be paid to the fact that almost half of the studied patients had at least one relapse, therefore, these cancer patients need regular screening of the bladder using computed tomography, ultrasound, cystography, cystoscopy with biopsy in order to detect the recurrence of the neoplasm in a timely manner.
Conclusion.The structure of the incidence of RMP in the Voronezh region is dominated by male urban residents, active, able-bodied age, which gives social significance to this disease and puts it in the category of environmentally indicator pathologies characterizing the health status of residents of the Voronezh region

Молодежный инновационный вестник. 2023;12(S2):243-246
pages 243-246 views


Zagryadskaya D.O.


Radiation cystitis occurs some vascular changes and impaired trophic function of the mucous membrane, resulting in the destruction of bladder cells, which occurs as a side effect of radiation used in the treatment of cancer.

This complication may occur during treatment and more than 6 months after the completion of therapy. 

The purpose of this study is to prevent radiation-induced cystitis.

Materials and methods. The study involved 40 patients with locally common cervical cancer, receiving a radical course of

chemoradiotherapy. According to the morphological structure, all women were diagnosed with squamous cell cervical cancer of varying degrees of differentiation. The average age of women was +51.4 years.

The patients were divided into 2 groups. The 1st group is the main one: in order to prevent radiation urological complications, they received

"Kanefron N". Group 2 - control.

The dynamics of treatment was tracked b interviewina. examining the records of an individual patient observation map and clinical trials.

The patient evaluated the complaints independently

(Validated Russian version of the cystitis symptom assessment scale (ACSS)):

before the start of treatment, in the process (2-at 10 session of DLT) and upon completion of therapy.

Urological complications were also assessed on the Radiation

Therapy Oncology Group (RTOG)/European Organisation for Research and Treatment of Cancer (EORTC) and National

Cancer Institute Common


Results. In the control group, the frequency of exacerbation of chronic cystitis was significantly higher than in the main group, which required the prescription of antibacterial therapy. In the control group, 11% of radioinduced cystitis of

1-2 degrees of gravity were recorded on the RTOG scale.

No complications have been identified in the main group.

Conclusions. These results make it possible to recommend “Kanefron N” as an accompanying therapy for chemoluvous treatment of RSM.

Молодежный инновационный вестник. 2023;12(S2):246-247
pages 246-247 views


Korobov I.V.


Primary multiple malignant neoplasms (PMNNO) are simultaneously or sequentially independently developed tumors in one patient, the pathogenesis and pathomorphosis of which are different. They develop in one or several organs, independently of each other. According to the time of occurrence, synchronous, which are diagnosed simultaneously or within 1 year, or metachronous, which are diagnosed after a year or more, are distinguished. that when a single localization of a tumor lesion is detected, there is a possibility of the existence of a multiple lesion. Materials and methods. In most cases, two tumor lesions are identified. The possibility of the existence of triple localization occurs in 6–8% of cases. It is rare for a patient to have more than 4 tumors. In the context of an increase in the overall incidence of malignant neoplasms of a single localization, recently there has been an orientation towards an increase in patients with PMNO. The number of newly diagnosed PMNO in patients varies from 5 to 17%. A clinical case was considered, 4 tumor lesions were detected in patient S., she underwent a number of diagnostic measures, due to which it was possible to diagnose malignant neoplasms in the early stages and treatment was carried out simultaneously. To date, the issue of the moment of occurrence of multiple tumor lesions has not been resolved, nor has algorithm for their early diagnosis and, consequently, the question of timely and adequate treatment of patients with such a pathology remains open, which makes the topic relevant.                                                                                     Results. On the example of a clinical case, which is described below, it can be said that a tumor diagnosed at an early stage is easier to treat, which leads to a complete recovery of the patient. The main direction in identifying primary multiplicity, along with the clinic, is the search for associations of human biological markers. Conclusion. The available data will be of significant interest for practical healthcare and for research work, because. PMNOs are an excellent model for studying multifactorial susceptibility to cancer.

Молодежный инновационный вестник. 2023;12(S2):248-250
pages 248-250 views


Morozova A.V., Martynyuk D.S.


Relevance. Among all malignant neoplasms in women, the leading place is occupied by breast cancer, which can be detected in the age group of 30-59 years (17.1%). The main task of oncology is research in the field of oncogenesis, diagnostics, treatment and prevention of tumors.
Goal. To conduct an analysis among patients for 2020 and 2021 with a diagnosis of breast cancer after surgical treatment according to such parameters as age group, lesion side, number of tumors, pathomorphological stages of malignant neoplasm, name of the operation, its time and volume of blood loss.
Materials and methods. Out of 768 patients with breast cancer (25-89 years old), surgical treatment was performed for the period 2020-2021 at the Samara Regional Clinical Oncology Dispensary. We decided to look at all possible parameters, evaluate and analyze the age of our patients, with what probability the side of the lesion is more common, in what number tumors predominate, find a more effective surgical treatment, calculate the average time of surgery and the amount of blood loss.
Results. According to the results of our study for 2020 and 2021, women aged 65 to 69 years (17.70%) were most often subjected to surgical intervention. The main localization of breast cancer prevails on the left side (54.20%). More often, one neoplasm is found in our patients (88.55%). Diagnostic studies of patients allowed to establish a diagnosis in the early stages, which favorably influenced the outcome of the disease (most of all with stage IIA: T2N0M0 (31.25%). Madden mastectomy surgery is the most common among women with breast cancer (74.08%). The amount of blood loss averaged 50 ml (38.02%), and the time in the last 60 minutes (36.60%).
Conclusion. The study showed that the most effective surgical treatment is to perform a Madden mastectomy, which helps to reduce the risk of complications. Early diagnosis and primary prevention of breast cancer has a positive effect on the outcome of the disease. Lifestyle and environmental factors play an important role in the development of this disease.

Молодежный инновационный вестник. 2023;12(S2):250-252
pages 250-252 views


Nizhelskoy D.A.


Annotation. Rationale: The problem of laryngeal cancer over the past 25-30 years has become more relevant due to an increase in a high percentage of disability, as well as a growing incidence rate (according to the World Health Organization for 2021, 2.5-2.7 cases per year per 100 thousand people ), which is associated by many scientists with the progression of tobacco smoking and alcohol abuse in the world. The average age of patients with verified laryngeal cancer in Russia is 63 years, of which the proportion of men is 98%, about 85% of all deaths from laryngeal cancer correlate precisely with cumulative alcohol consumption, smoking both actively and passively, as well as the presence of occupational hazards, which represents a special social significance of the study of this aspect in the territory of the Voronezh region.
Objective: To study the adherence to smoking and alcohol abuse in patients with laryngeal cancer.
Methods. An analysis was made of 100 case histories of male and female patients with laryngeal cancer in the period from 2020 to 2023. Patients who received surgical treatment in the conditions of the department of head and neck tumors of the BHI Voronezh Regional Clinical Oncological Dispensary were surveyed.
Results. As a result of the research, we have established the gender and age characteristics of laryngeal cancer. The main cohort of patients were men (94 people out of 100). The medical histories of these patients were analyzed, it was found that 85% of them had a smoking experience of more than 20 years, and 15% had passive smoking (cigarettes) in their life history. Along with this, 37% of patients note the intake of alcoholic beverages every week. Data were obtained that 87% of all men smoke, and 33% of all women. In addition, according to the results of the survey, it was found that of all smoking men, after verification of the diagnosis and treatment, 43% continued to smoke, and 0% of women.
Conclusion. The results of the study confirm the relationship between the occurrence of laryngeal cancer and a history of long-term smoking and alcohol consumption, reflect the age and sex characteristics of this nosology, demonstrate a high percentage of patients diagnosed at stages II-III, indicate the need for oncoscreening, the implementation of preventive measures , identifying risk groups for laryngeal cancer, oncological informing patients with an average and high risk of developing this nosology in the period before the onset of the disease, as well as correcting lifestyle after its verification.

Молодежный инновационный вестник. 2023;12(S2):253-255
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Poddybnaya Y.Y., Repnoy K.A.


Relevance: Cancer of the female reproductive system is the most frequently diagnosed type of cancer in women in Russia, accounting for 17.2% of all cancers in women.

Purpose: to study the risk factors for cancer of the reproductive system in women and identify the most significant for the development of this oncology.

Materials and methods: To determine the risk factors for cancer of the reproductive system, we interviewed about 225 women using the questionnaire method. Based on the results of the data obtained, an analysis of risk factors that affect the occurrence of cancer of the female reproductive organs was carried out.

Results: According to the results of the questionnaire for the presence of oncogynecological risk factors, only 58.7% of the women surveyed annually undergo an examination by a gynecologist and 46.7% are tested for oncocytology every three years, which indicates the ignorance of the female half of the population in the prevention of cancer of the female reproductive system .

Conclusion: An analysis of the risk factors for malignant neoplasms of the female reproductive system showed that many women do not know and, therefore, do not adhere to the simplest standards in the prevention of oncological diseases of the reproductive system.

Молодежный инновационный вестник. 2023;12(S2):255-257
pages 255-257 views


Poiminova P.Y., Guzenko A.E., Tyukov G.A.


According to epidemiological data, it is known that 2-3% of malignant neoplasms in women are vulvar cancer. According to 2018 statistics, the incidence of vulvar cancer in the Russian Federation was 2.6 cases per 100,000 female population.
Goal. To identify the advantages of surgery with reconstruction, to assess the complications that occur in patients in the postoperative period.
Materials and methods. The article analyzes the possibilities of performing surgical treatment of patients with vulvar cancer.. On the example of two groups with this disease, surgical treatment of cancer without reconstruction and with the use of reconstructive surgery using skin-fascial flaps from the posterior and medial surfaces of the thighs and buttock area was considered.
Results. They showed the positive and negative sides of these operations. And it was also found out that the main difference between a surgical operation with reconstruction is a wide excision of the affected area with vulvar anatomical structures and the restoration of the resulting wound with skin-fascial flaps. In addition, an assessment of complications in patients in the postoperative period was given. It was found that patients with reconstructive surgery have much fewer complications, since there is a sufficient volume of tissues, good blood supply, which allows the operation to be performed without stretching the edges, and also makes it possible to achieve the most satisfactory cosmetic result.
Conclusions. Choosing the right method of treatment for malignant neoplasms of the vulva is one of the most important problems in oncology. Thus, reconstructive surgery has a sufficient number of advantages in contrast to operations without reconstructions.

Молодежный инновационный вестник. 2023;12(S2):257-259
pages 257-259 views


Ryasnyaskaya L.V., . Korotkova O.M.


Relevance: due to modern advances in the treatment of breast cancer, the rehabilitation of treated patients has become an urgent problem. To form an individual approach, it is necessary to assess the psychological state of the patient.Objective: to assess the impact of comprehensive rehabilitation of patients suffering from / operated on for breast cancer on the psychological state and quality of life.Methods: the necessary outpatient cards were requested from the archive to conduct the study. A card was filled out for each patient and an entry was created in the table on the rehabilitation measures carried out and the data on the assessment of the psychological state. The main objective of the study is to confirm the impact of rehabilitation on patients with breast cancer by assessing their psychological state and quality of life, taking into account the personality profile.Results: 40 patients were included in the study. The observation period is up to 30 days . In the course of the study, a lower level of anxiety was found in patients with a harmonious type of attitude to the disease, in patients with reconstruction, the level of anxiety was significantly lower (P=0.03).When assessing anxiety on day 10 in patients with LV reconstruction and hypochondriacal type of attitude to the disease, there is a significant decrease in the level of anxiety.Conclusion: the use of rehabilitation in combination with the reconstruction of the LV significantly reduces the level of anxiety, depression in the postoperative period and improves the quality of life

Молодежный инновационный вестник. 2023;12(S2):259-262
pages 259-262 views


Spiridonov D.A., Proscyrakova O.V., Andreev V.A.


Relevance. The life expectancy of cancer patients depends entirely on full-fledged dispensary observation, where key attention is paid to the early detection of relapses and metastases of the primary malignant focus. Today, the interest of doctors of all specialties in neoplasms of the adrenal glands is growing, especially in patients with a burdened oncological history. However, the data regarding metastatic adrenal cancer in most cases are based on the results of autopsy. This dictates the need to update the results of an intravital study of the histological material of adrenal neoplasms in patients, which will make it possible to develop tactics for the management and subsequent treatment of patients. Materials and methods. The medical documentation of patients with a history of malignant neoplasms was studied, in which, during the planned dispensary observation, ultrasound and then MRI (CT) of the abdominal cavity and retroperitoneal space revealed the presence of tumors of the adrenal glands. Material for pathomorphological examination was obtained by performing a biopsy of the tumor and laparoscopic adrenalectomy. The discussion of the results. Histological examination of the obtained material made it possible to identify benign and malignant (metastatic) lesions.

Молодежный инновационный вестник. 2023;12(S2):262-263
pages 262-263 views


Spiridonov D.A., Proscyrakova O.V., Andreev V.A.


Relevance. The incidence of malignant neoplasms of various localizations is steadily growing in the world. Progress in instrumental diagnostics contributes to the detection of solitary metastases in various organs of the human body, including the adrenal glands. Often this happens during a dispensary examination of cancer patients. However, the question of the advisability of surgical treatment or radiation therapy of such metastatic foci has not been resolved to date. Materials and methods. The medical records of 28 patients were studied and analyzed, in whom, after radical treatment of malignant neoplasms of various localizations, metastatic neoplasms in the adrenal glands were found. Patients underwent removal of metastatic foci in the adrenal glands. Surgical benefits were performed in different volumes, which was individual in each case: the localization of the primary malignant focus, the spread of a metastatic tumor, the somatic status and age of the patient, and comorbidities were taken into account. The discussion of the results. According to the data obtained, the 5-year survival of this group of patients was 44%. This was higher than in patients who, according to the literature available to us, did not receive specialized treatment for solitary metastatic foci in the adrenal glands.

Молодежный инновационный вестник. 2023;12(S2):263-263
pages 263-263 views


Spiridonov D.A., Proscurykova O.V., Andreev V.A., Elizarov H.V.


Relevance. Recently, the number of patients with rectal cancer has been steadily growing, which is one of the “leading” cancer nosologies in terms of mortality structure. The research methods that have become routine (sigmoidoscopy, X-ray and endoscopy) are not always informative in relation to determining the extent of the tumor in relation to the intestinal wall, generalization of the disease, and detection of relapse. The main role in the diagnosis of pathological changes in the rectum is given to modern methods of radiation diagnostics - MRI, CT, PET-CT. Currently, ultrasound of the rectum is becoming increasingly important. Materials and methods. The results of ultrasound examination of patients with rectal cancer during the initial diagnosis and after specialized antitumor treatment in order to detect relapses using the diagnostic options of the Hitachi Arietta V-70 expert-class ultrasound scanner were considered and studied. The discussion of the results. Ultrasound examination allows to visualize pathological changes in tissues and focal formations in the rectum with high accuracy, which makes it possible to determine methodological approaches to surgical and chemoradiation treatment of rectal cancer, monitoring patients with cancer of the specified localization

Молодежный инновационный вестник. 2023;12(S2):264-264
pages 264-264 views


Tyukov G.A.


Relevance. Cervical cancer is one of the most urgent problems in modern oncogynecology.

Objective. To analyze the available foreign and domestic studies on the problem of cervical cancer, calculate the economic losses from this pathology in the Voronezh region, determine approaches to overcome the problem and propose a reasonable solution.

Materials and methods. Foreign research published in the electronic library PUBMED, native studies published in the electronic library eLIBRARY.RU, including materials from the international scientific forum "Russian experts against cervical cancer" (2012, Italy, Rome) testify that vaccination is the only effective method of combating cervical cancer . Based on the data of the Federal Statistical Observation from the Federal State Statistics Service and mathematical formulas developed in the course of scientific work, a calculation of economic indicators was made, extrapolated to the subject of the Russian Federation - the Voronezh region. The methods of system analysis and medical statistics were used for the study.


1 - Based on the analysis, it was found that cervical cancer is an urgent medical, social and economic problem.

2 – The research medical and economic analysis provided information on medical and economic losses as a result of cervical cancer.

3 – Accounting were calculated to overcome this problem on the basis of vaccination.

4 - Formulated proposals to reduce the severity of the problem associated with cervical cancer.

Conclusions. The use of vaccine prevention can reduce the incidence in women of reproductive age, which undoubtedly has a positive effect on the medical, social, and economic spheres of human life.

Молодежный инновационный вестник. 2023;12(S2):264-267
pages 264-267 views


Chernyshova D.S.


Relevance: operations like radical mastectomy for breast cancer are always difficult from the point of view of the physical and psychological state of a woman. After the surgical treatment, various complications may develop, for example, post-mastectomy syndrome, concerning both the physical condition of the patient and the state of her psyche, which indicates in favor of mandatory rehabilitation of cancer patients by rehabilitologists and psychologists.
Purpose: analysis of the results of psychological tests before and after rehabilitation, analysis of the results of physical examinations by an oncologist-mammologist before and after rehabilitation.
Materials and methods: to analyze the state of the patients' psyche, such questionnaires and tests as the Eysenck self-assessment test of mental states, the Beck questionnaire and the scale for psychological express diagnosis of depressive disorders were used. A physical examination was also performed by an oncologist-mammologist to identify postoperative complications.

Молодежный инновационный вестник. 2023;12(S2):267-268
pages 267-268 views



Alvane K.H., Aralova V.S.


Relevance. Scoliosis is a pathology of the musculoskeletal system, which is a lateral curvature of the spine in the frontal plane. Currently, scoliosis is an important medical and social problem, since the progression of this disease is often accompanied by complications in the form of structural and functional disorders of other organs and systems.

Goal. To assess the prevalence of various forms of congenital and acquired scoliosis and their possible complications from the respiratory, digestive, cardiovascular and genitourinary systems among children and adults.

Materials and methods. Data on the disease of scoliosis of 152 people in the age range from 5 to 34 years were analyzed on the basis of the Center for Prosthetics and Orthotics of the Family Medicine Clinic "Eucalyptus", Voronezh. The main object of our study are 145 patients in the age range from 5 to 34 years old suffering from scoliosis of 2-3 degrees and currently being treated at the Center for Prosthetics and Orthotics of the Family Medicine Clinic "Eucalyptus".

Results. It was found that 78.62% of cases (114 people) out of 145 patients, regardless of gender, accounted for idiopathic scoliosis (mainly the age group of 13-15 years), 10.34% - post-traumatic scoliosis, 2.76% - de novo scoliosis (30 years and older), 4.83% - juvenile scoliosis (4-5 years), 3.45% - congenital scoliosis caused by abnormalities in the development of the spine (spina bifida, spinal hernias, dysplastic scoliosis). In 38 patients (26.21%), scoliosis is accompanied by pronounced disorders from various organs and systems, which account for: 17 (11.72%) – the presence of complications from the respiratory system, 12 (8.28%) – the digestive system, 5 (3.45%) – the genitourinary system, 4 (2.76%) – cardiovascular system. 

Conclusion. The incidence of acquired scoliosis significantly exceeds the proportion of congenital scoliosis, and most of the cases are patients with idiopathic scoliosis, regardless of gender. Of particular interest is the problem of the occurrence of de novo scoliosis, characteristic of adults aged 30 and older, since there are no generally accepted criteria for diagnosis, classification and treatment principles. For timely diagnosis and treatment of complications of scoliosis, patients under the age of 18 need consultations with: an orthopedic traumatologist, a pediatrician, a neurologist, a dentist, a gynecologist, a physical therapy doctor, a physiotherapist.

Молодежный инновационный вестник. 2023;12(S2):269-271
pages 269-271 views


Aralova V.S., Alvane K.H.


Every year in the world by 12.5% there is an increase in the number of cases of autoimmune diseases (AD), which are based on the development of a cascade of immune responses to antigens of the body's own tissues. These diseases are one of the main causes of disability in the population. ADs include: diabetes mellitus, rheumatoid arthritis, autoimmune thyroiditis (AIT), celiac disease, and others.

Purpose. To analyze the prevalence of autoimmune diseases among university students and evaluate the role of the hereditary factor.

Materials and methods. We analyzed data on the presence of autoimmune diseases in 243 students enrolled in higher education programs from 1 to 6 courses. The research method was an online questionnaire, which contained a list of questions aimed at identifying autoimmune diseases and hereditary predisposition.

Results. According to the data obtained during the study, it was found that 3.7% of respondents have autoimmune diseases (diabetes mellitus, AIT, celiac disease, rheumatoid arthritis). 6.3% have a hereditary predisposition - relatives suffer. It has been established that the female population is at higher risk than the male population.

Conclusion. It should be said that autoimmune diseases are considered difficult to treat at the moment and require a more detailed study of the features of pathogenesis, diagnosis and treatment. It is also worth noting that great importance is given to heredity in the development of autoimmune diseases.

Молодежный инновационный вестник. 2023;12(S2):272-275
pages 272-275 views


Volynkina E.A., Khodarina Y.V., Makeeva A.V.


Relevance. More than 600 million cases of a new coronavirus infection with a mortality rate of about 1% have been registered in the world so far. People with comorbidities, including diabetes mellitus, are more susceptible to the adverse course of COVID-19. Numerous studies confirm that post-COVID syndrome is more likely to form in the presence of diabetes mellitus.
Objective of the study. To reveal characteristic features of course and diagnostics of new coronavirus infection against the background of concomitant diabetes mellitus taking into consideration pathophysiological ways of mutual influence of these pathologies.
Materials and Methods. Questions of course and diagnostics of new coronavirus infection on a background of diabetes mellitus have been studied; main pathogenesis pathways in this comorbid condition have been analyzed, the factors influencing negatively on the patient's state against the background of the disease development have been revealed. To confirm or refute the hypotheses, data of 154 patients who were treated at the "COVID-8" department of the VCCEH No.10 during the period from October 2020 till March 2021 were collected and analyzed. The data were statistically processed using Microsoft Excel 10.0 and StatSoft STATISTICA 12.0 software packages.
Results of the study. Compared with the CORONADO data, obesity was much less common in the present study. Of the comorbidities, hypertension, CHD, and coronary artery disease were identified to the greatest extent. Differences with baseline data were also observed for the main complaints. Patients with diabetes mellitus type 2 are characterized by more severe form of the disease according to many indicators. However, there was no statistical significance in the differences in CT and some laboratory indexes.
Conclusion. Understanding the pathophysiological mechanisms of the mutual influence of DM and a new coronavirus infection on the body will serve as a tool for choosing an appropriate drug therapy and help to achieve better treatment results.

Молодежный инновационный вестник. 2023;12(S2):275-279
pages 275-279 views


Ivanova P.E., Stepkin D.I.


Topicality: Chronic cholecystitis occurs 20% of the world population. To develop successful methods of prevention and timely treatment it is important to determine the contingent of people who have chronic inflammation of gallbladder most frequently.

Objective: To study statistically the data on chronic cholecystitis cases and determine the category of people at risk of this pathology.

Materials and Methods: The study was carried out on the basis of the electronic archive of the surgical department of CHUZ KB "RZD-Medicine" of Voronezh. 100 patients admitted to the department with the diagnosis of chronic cholecystitis in autumn 2022 were analyzed by sex, age criteria, and comorbidities.

Results: Chronic cholecystitis is most common in women aged 35 to 60 years. This pathology is systematically accompanied by hypertension and other cardiovascular diseases.

Conclusion: To minimize the chances of occurrence of chronic cholecystitis, the risk group should strictly follow preventive measures. They consist in a diet of a fractional meal with a reduction in the diet of fatty foods, the consumption of sufficient fluids, the treatment of cholelithiasis, and sufficient motor activity. Regular observation by a gastroenterologist is also recommended for this category of people to detect possible pathology at an early stage.

Молодежный инновационный вестник. 2023;12(S2):279-280
pages 279-280 views


Kiseleva A.S., Meshcheriakova J.E.


Revelance. Obesity today is the leading problem among the population, so the most relevant is to find out the causes and assess the risks of developing this pathology in students. As a result of urbanization, sedentary lifestyle has become not only a peculiar habit for modern society, but also the main reason for the development of this pathology. In 2020, with the emergence of the new Covid-19 virus, the level of physical inactivity increased, which provoked an increase in body weight in the majority of the population, resulting in the development of obesity.

Objective. The aim of the study is to analyze the level of obesity among the students of the Burdenko State Medical University and to assess the risks of its development.

Methods of the study. The study was conducted with the help of an electronic version of the questionnaire created on the Google platform. It was sent out via social networks. 190 students of N.N. Burdenko State Medical University aged 17 to 25 took part in the survey.

Results. The results obtained in the study were evaluated according to the following criteria: assessment of body mass index (BMI); presence of concomitant diseases in students and their relatives; factors predisposing to the development of obesity; presence of relatives suffering from obesity.

Conclusion. On the basis of the obtained results the relationship of alimentary, hereditary factors, sedentary lifestyle of students with the development of obesity in young generation was revealed. The simultaneous presence of three factors in the future will have a negative impact on health, and as a consequence will lead to the development of cardiovascular system diseases, which are among the leading causes of mortality in people. Therefore, in this group of people, it is important to regularly monitor their body weight and to take measures to reduce it if their BMI level is exceeded.

Молодежный инновационный вестник. 2023;12(S2):280-282
pages 280-282 views


Nefedova D.S., Frolov A.Y., Razenkov I.A.


Relevance: According to the EF research group of the International Committee on Virus Systematics, on February 11, 2020, the official designation of the new virus, SARS-CoV-2, and the disease it causes, COVID-19, the most prominent manifestation of which is the development of severe bilateral pneumonia, was announced. SARS-CoV-2 belongs to the family of RNA-containing viruses whose entry gates are the epithelium of the upper respiratory tract, gastric and intestinal epitheliocytes. The virus penetrates and damages target cells with angiotensin-converting enzyme type II (ACE2) receptors. The severity of the course of the disease is largely caused by concomitant diseases, such as carbohydrate metabolism disorders. In this regard, the study of metabolic disorders in the body with worsening course of diabetes mellitus is of particular relevance.

Objective: To study the pathophysiology of carbohydrate metabolism in COVID-19 coronavirus-infected patients with concomitant decompensated manifest type 2 diabetes mellitus.

Methods of the study: The study analyzed the medical records of 47 patients aged 40 to 60 years (including 21 women and 26 men) diagnosed with coronavirus infection caused by COVID-19 virus with concomitant community-acquired bilateral multisegmental pneumonia with a moderate course (respiratory failure grade 1). The virus was confirmed by PCR test. The study was carried out on the basis of VOHKB №1. The results of the study were evaluated according to the indices of biochemical blood analysis in the acute phase of the disease (when the patient was admitted to the hospital) and in the recovery phase (when the patient was discharged). Such parameters as glucose, bilirubin, ALAT, ASAT, creatinine, urea, amylase, total protein and hematocrit were assessed. Statistical processing of the data was performed using Student's t-criterion at p≤0.05.

Results:The studies revealed an increase in glucose levels on admission to the medical institution, with an average level of 10.58 mmol/l (9.8-12.1 mmol/l). It was revealed that in manifest DM hyperglycemia was persistent, despite increasing the dose of insulin to correct the condition, leveling of glucose levels to normal could not be achieved.  At discharge, the mean glucose level was 7.43 mmol/L (6.7-7.8 mmol/L). Excess of the statistical average ASAT AND ALAT values was determined (in 87.6% and 81.3% of patients, respectively), indicating the activity of cellular cytolysis.

Some average indices of biochemical blood analysis were within upper normal values, such as: bilirubin 15,62±2 µmol/l (with the norm 8,5-20 µmol/l), creatinine 87,8±4 µmol/l (with the norm 60-124 µmol/l), urea 8,26±0,7 mmol/l (with the norm 2,4-8,3 mmol/l). Amylase, total blood protein and hematocrit values corresponded to average normal values.

Conclusion: On the basis of the data obtained in the study, it was found that hyperglycemia in patients with diabetes mellitus is exacerbated due to the specific action of the virus.

This effect of the pathogen leads to a more severe course of the disease, namely severe pneumonia with severe respiratory failure, persistent inflammation and more severe complications such as hepatic and renal failure, as well as impaired function of these organs. Therefore, in this category of patients, it is important to conduct regular monitoring of blood glucose levels and measures to maintain sugar levels within normal limits.

Thus, a detailed study of the conditions and mechanisms of COVID-19 exposure in patients with diabetes mellitus has significant scientific and practical importance for predicting the course of the disease, their complications and prescribing the appropriate specific therapy for this category of patients.

Молодежный инновационный вестник. 2023;12(S2):282-284
pages 282-284 views

Философия и гуманитарные дисциплины в XXI веке


Abramova A.V.


Relevance. The relevance of the topic is determined by its content and the high standard of ethical requirements imposed on the work of medical personnel in recent years.

Purpose: to study the views of 1st and 6th year students of N.N. Burdenko VSMU on ethics in medical activity.

Methods: questionnaire, analysis, survey, generalization method.

The article discusses the importance of medical ethics in medical activity, ethical principles, deontology as a component of ethics. The profession of a doctor both in ancient times and now is one of the humane ones, which determines the essence, meaning, attitude and views of society towards medical workers. Every person in his life has never turned to doctors for help, thereby entrusting health to a representative of medicine. When visiting a medical institution, everyone has the right to hope for respectful treatment, decent, honest communication, and an ambulance if necessary. Professional medical ethics helps a medical professional to choose the most correct, respectful, morally acceptable line of behavior in a variety of situations during work. This determines the interest in considering this issue. The concept of medical ethics and deontology is proposed, the problems of medical ethics are highlighted. The discoverers of these directions, the basic principles, the importance of studying this issue from the point of view of medicine are considered. The results of the study are proposed, which identifies the most important aspects in medical ethics and views on the medical activities of students of the 1st and 6th courses of N.N. Burdenko VSMU.

Results: most students of N.N. Burdenko VSMU consider ethics to be an important part of professional skills, noting that professional ethics can and should be studied.

Conclusion. In conclusion, I would like to note that the topic of medical ethics has been of interest to students of our university since the first day of training. Professional ethics is perceived as an important trait that needs and can be learned. The results of the study showed that selfishness is perceived by all respondents as a negative professional trait, and mercy and truthfulness in the work of a doctor are important criteria that support the image of the profession.


Молодежный инновационный вестник. 2023;12(S2):285-286
pages 285-286 views


Abramova A.V.


The relevance of the topic is determined by the content of events about which not so much is known to the masses and relevance as an example of incredible feats.

Purpose of the work: analysis of the latest sources on the history of the siege of Leningrad.

Methods: comparative method.

The article is devoted to one of the most important events during the siege of Leningrad, namely the construction of a road laid in winter along the frozen Lake Ladoga "Road of Life". Being one of the main ways to promote food at that time. The complete isolation of Leningrad excluded almost all possible counter-actions. The city, left without food under constant shelling from the Germans, experienced incredible torment. It seemed that it was impossible to interrupt this sequence. But thanks to the decision of the Leningrad Front council, a solution to the problem of food and weapons supplies is being received. Initially, it was very problematic, which caused some doubts about the success of the conceived plan. Lake Ladoga caused difficulties for many vessels during the voyage, but with the onset of winter, it was decided to lay the route directly on the ice. Which immediately raised a lot of questions about the construction, but the supply of food to people was in the first place. How much effort was invested in the construction of the route simply cannot be expressed in words. The constant bombing by the Germans, weather conditions and the lake itself complicated the performance of this task. Huge difficulties only strengthened people's faith.

Results. Currently, the world has once again become an arena of armed confrontation between the largest world powers. As 80 years ago, movements of different ideological orientation, but united by the misanthropic nature of the ideology promoted by them, appear and become widespread as if from the world of shadows.

Conclusion. During the confrontation with them, situations similar to the one that took place in Leningrad during the Second World War became possible again. This is especially evident in the example of Donbass. The experience of courageous struggle against the enemy and overcoming all the hardships of the war is more relevant today than ever.


Молодежный инновационный вестник. 2023;12(S2):286-288
pages 286-288 views


Averyanova P.V.


Relevance. The topic is borderline at the junction of two sciences - political (elitology) and historical. The study of A.V. Kolchak's diverse activities is an integral part, firstly, of elitology, which studies the formation, activity and collapse of the Russian elite, and also of historical science, because these activities took place in the early twentieth century and culminated in the global changes in the country.
Research Objective. To examine and analyze the dynamics of development, trends, and identify the factors that influenced the formation.
Materials and methods. The following methods have been applied: a logical method, a comparative method, a descriptive method and a comparative method.
Results. The correlation of historical processes with the formation of Admiral Kolchak as a figure that influenced the development of some events in the national history is revealed.
Conclusion. It is impossible to give an unequivocal estimation of his life path and activity. In recent decades, active attempts have been made to rehabilitate the heroes of the White movement, including A.V. Kolchak. The public perceives him from two positions: either as a Siberian executioner, creator of concentration camps for Red Army soldiers, dictator and monarchist, or as a "polar idealist". Thus, because of such a sharp discrepancy in the assessment of active participants in the White movement (not only with regard to Kolchak), Russian society is split into two camps.

Молодежный инновационный вестник. 2023;12(S2):288-291
pages 288-291 views


Grichanyuk A.A., Zhiryakova E.C.


Relevance: In modern realities, the problem of memory is most relevant. The events of the Great Patriotic War still terrify the citizens of the former Soviet Socialist Republic to this day, the war affected every Russian family and there is not a single family whose representatives did not feel all the horror of that time. Women, men, children, all fought to the last drop of blood. People should always remember their heroic deed, they need to pass this information on to their children and grandchildren, because as long as the memory exists in our hearts, the person himself is alive.
Purpose: To convey to readers information about the biography of one of the Russian soldiers, Apanasenko Joseph Rodionovich.
Research methods and materials:
theoretical: theoretical analysis of literary sources, newspaper articles, Internet resources.
empirical: the study of historical events of the past years.
Result: We revealed the military path of Joseph Rodionovich Apanasenko, the formation of his personality in the ranks of the Red Army.
Discussion: in the course of the work, we found that Joseph Rodionovich Apanasenko became famous among the soldiers of the Red Army. His biography reflects the war from the side of the commanding staff. The generals were responsible not only for the Motherland, but also for the life of every Soviet soldier.
Conclusion: In the modern world, it is necessary to promote the memories of the heroes of the Great Patriotic War so that descendants do not forget, honor the exploits of their ancestors and pass them on to their children.

Молодежный инновационный вестник. 2023;12(S2):291-294
pages 291-294 views


Didigova A.A.


Relevance. In the modern world, in the era of transformation and globalization, the problem of value education of the younger generation is becoming especially urgent. Art, as a form of social consciousness and part of the spiritual culture of society, is able to form a value worldview of an individual.
Goal. The study of the influence of art in general and various genres of art on the formation of the value worldview of the individual.
Materials and methods. Comparative and comparative analysis, generalization of theoretical material are used. The author relies on a historical and philosophical approach and psychological research in studying the problem of the influence of art on the moral education of the individual.
Results. The problem of the influence of art on the formation of personality has interested a person since antiquity. Plato and Aristotle are among the first thinkers to emphasize the influence of art on the formation of human value orientations. In the Renaissance, art becomes one of the tools for the formation of an ideal universal personality. Later, German philosophers drew attention to the reflexive function of art, the possibility of revealing the spiritual potential (I. Kant) and the cognitive function of art (G. Hegel). Russian philosophers L. N. paid special attention to the role of art. Tolstoy, I. A. Ilyin, N. A. Berdyaev, who believed that art elevates the individual and promotes moral renewal. From the point of view of modern scientific research, it has been noted that art can have a positive effect on a person's emotional state, improve mental activity and concentration, as well as reduce the level of the stress hormone. Thus, art gives a person harmony and tranquility, without which it is impossible to form a full-fledged personality.
Various genres of art have specific ways of influencing a person. For example, literature contributes to the formation of correct ideals, enriches a person's life experience and develops empathy; music educates emotional intelligence, helping to better understand one's own feelings and the feelings of others, enriches emotional and sensory experience; painting develops attentiveness, prudence, patience in the search for truth and extraordinary creative thinking.

Conclusions. Art is the strongest tool for educating a person's value worldview, developing spiritual qualities of a person, moral foundations and ideals. It not only educates, but humanizes, forms a person as a full-fledged personality.

Молодежный инновационный вестник. 2023;12(S2):294-297
pages 294-297 views


Yemets S.I.


The relevance of the topic is interesting because of the problems associated with the taking away of values from representatives of the Russian Orthodox Church. A particularly blasphemous case unfolded in 1922. The purpose of the work is to consider in more depth the initial stage of the confiscation stage from the very beginning. Pay attention to the forms and guidelines in which this was expressed, as well as one of the important components is the reaction of the priests themselves to these outrages. The materials and methods of research are determined by scientific articles, monographs, and literary works. The results that have been identified determine that the main provisions of the period on the seizure of Church property have been revealed. The methods, tasks and results of all the general work of the Bolsheviks to eliminate the Church as such from the political arena were subject to a thorough analysis. The conclusion contains conclusions that could be determined at the entire stage of consideration of this topic. Despite all the attempts of the Soviet state to replenish the treasury at the expense of the Church, as can be seen later in the recalculation of funds, all these attempts were not crowned with what the state hoped for.

Молодежный инновационный вестник. 2023;12(S2):297-299
pages 297-299 views


Levchenko S.M., Soboleva E.A., Makashova A.I.


The purpose of the article. The article is devoted to the study of existing stereotypes associated with medical activities. Prejudice has a big impact on teenagers who plan to become doctors but are hesitant because of the standards imposed by society. Based on the analysis of the results of a sociological survey of medical students of different courses, it was established which of the stereotypes influenced their future career guidance. The relevance of the designated topic is associated with the problems of early career guidance. The data obtained during the study can be used in work with future medical school applicants.
The target. Identify the main stereotypes and show their failure. This is necessary so that every student can, without doubting himself, choose the specialty that he dreams of.
Materials and methods. Sociological survey on the platform "Google-form". Methods were used: analysis of the received information, work with statistical data, retrospective. A total of 120 respondents were interviewed.
The results. According to the survey, a list of stereotypes about doctors of special professions was revealed: dentists, therapists, pathologists and psychiatrists. In addition, in the course of the study, it was possible to find out what qualities are the standard, according to the respondents, for a doctor. These include: compassion - 63%, reliability - 81%, mindfulness - 92%, sociability - 76% and decisiveness - 74%.
the conclusion. As it turned out, at the heart of any society there are stereotypes caused by false judgments. Their occurrence was influenced by the ambivalent opinions of people about doctors, which are not supported by personal experience and are based only on rumors. It is important to take into account this factor in the course of career guidance work with future applicants and respond to it in a timely manner

Молодежный инновационный вестник. 2023;12(S2):299-301
pages 299-301 views


Radchenko A.V.


Annotation. The article is devoted to the life and state activity of Prince Platon Alexandrovich Shirinsky-Shikhmatov.
The relevance of this topic is indisputable, because today there is a historiographic problem, since in fact this topic has not been studied, there is not a single serious monograph by such a significant person as Prince Platon Alexandrovich Shirinsky-Shikhmatov.
The purpose of this study was to study the personality and state activity of Platon Aleksandrovich Shirinsky-Shikhmatov. Particular attention is paid to the activities of the prince as Minister of Public Education, while the policy of the Ministry in the field of education, enlightenment and Censorship is considered.
When writing this study, scientific methods were used: comparative analytical, the principle of historicism and the chronological method.
Results. As a result of the work done, it was concluded that during the period of his public service, Prince Platon Alexandrovich not only occupied the post of Minister of Public Education, but also the activities of Platon Alexandrovich Shirinsky-Shikhmatov as chairman of the Archaeographic Commission and its work as a whole are separately noted. This commission was engaged in identifying and publishing historical sources from ancient times to the end of the 17th century.
Conclusion. Prince Platon Alexandrovich did a lot for the Russian people in such a short period of his ministry: the teaching of the Law of God was strengthened, the influence of Philosophy was reduced, and the reading of Logic and Psychology was entrusted. Universities received the chair of Pedagogy or the science of education.Gymnasiums began to prepare young men for a classical education at universities and for admission immediately to the service in their specialty. County schools developed. An equally important merit of Prince Platon Alexandrovich Shirinsky-Shikhmatov was the publication of the Dictionary of the Church Slavonic and Russian Languages, the history of which is also discussed in this article. Also no less relevant is the charitable activities of Prince Platon Alexandrovich Shirinsky-Shikhmatov.

Молодежный инновационный вестник. 2023;12(S2):301-304
pages 301-304 views


Tarasov I.A.


Relevance. In this paper we consider the process of formation of the Liturgical Synodal Commission as a body responsible for editing liturgical texts prepared by the Diocesan Liturgical Commissions of the Russian Orthodox Church, as well as for the compilation of new Liturgical texts. This study has not been conducted before, which gives huge opportunities for study. In a short period of time, the Liturgical Synodal Commission has prepared and left a huge number of Liturgical texts that are currently approved or are at the stage of approval by the Holy Synod of the Russian Orthodox Church. Approved texts are widely used in parishes.
The purpose of this work is to study the history of the creation of the Liturgical Synodal Commission, its Liturgical heritage and contribution to the historical veneration of saints of past centuries and especially the New Martyrs and Confessors of the Russian Church of the XX century, which is very difficult to overestimate.
Research methods: The principle of historicism, a critical approach to the study of sources, structural analysis, comparison, generalization. description.
The result of the work performed is a detailed historical analysis of the creation of the Liturgical Synodal Commission, its Liturgical heritage and contribution to the historical veneration of saints of past centuries and especially the New Martyrs and Confessors of the Russian Church of the XX century.
Conclusion: in the course of the study, it can be said with certainty that the Liturgical Synodal Commission has justified and justifies the hopes that the Church has placed on it.

Молодежный инновационный вестник. 2023;12(S2):305-307
pages 305-307 views


Cherenkov I.Y.


Relevance. The presented work examines the medical experience of an outstanding doctor of our region, Nikolai Alexandrovich Ovchinnikov, who, after graduating from the 2nd Moscow State University, worked in such cities as Tambov, Michurinsk, Voronezh, and the villages of Khobotovo and Chernyanka and performed complex operations. This topic is relevant due to the fact that it has been little studied and is therefore of scientific interest. His medical experience, attitude to work and life path are very interesting to comprehend and understand.
Purpose: To characterize the medical activity of the hieromonk Nectary Ovchinnikov.
Methods: The principle of historicism, a critical approach to the study of sources, structural analysis, comparison, generalization.
Results: In Voronezh, before the Great Patriotic War, Nikolai Alexandrovich worked at the regional Institute of Blood Transfusion, which was headed by Fyodor Petrovich Verkhovykh, and then the regional blood transfusion station, which he headed on March 4, 1943, was restored by his forces. On February 20, 1950, he became the temporary head of the Voronezh Regional Air Ambulance Station. His experience as a doctor and his attitude to work are very important and relevant for understanding and comprehension. For him, there were no racial, class, gender or other differences in everyone who came to him with an appeal, he saw a person and a patient. Nikolai Alexandrovich, being not only a doctor, but also an Orthodox Christian, tried to help everyone who turned to him, if he had the opportunity. It is as a poet that he corresponds to the modern ideal of a doctor of the XXI century. In 1955, Nikolai Alexandrovich took holy orders and completed his medical ministry. Then he became seriously ill and in 1976 he took a monastic haircut with the name Nectary. After living for about 9 more years, bedridden, he dies.
Conclusion: It can be concluded that Father Nectary (Ovchinnikov) was a good doctor during his medical activity. He cared about people and tried to help his patients, whoever they were.

Молодежный инновационный вестник. 2023;12(S2):307-311
pages 307-311 views



Verlyanko M.S.


Relevance: Celiac disease is a hereditary disease with diverse clinical forms, which makes it difficult for a practical doctor to suspect it. Diagnosis of celiac disease is constantly improving, the latest recommendations of the European Society of Pediatric Gastroenterology ( ESPGHAN ) came out in 2020.

Purpose: To analyze the use of modern recommendations for clinical and laboratory diagnosis of celiac disease in practical healthcare.

Materials and methods: An analysis was made of the case histories of 17 children who were diagnosed with celiac disease for the first time in 2021, of which 10 were boys and 7 were girls. 6 years old - 3 people, 7-11 years old - 7 people, 12-16 years old - 4 people. The use of serological, genetic, morphological markers was analyzed.

Results : Celiac disease was suspected in 12 patients due to their belonging to risk groups. The symptoms were dominated by a lack of body weight and abdominal pain (11 people), that is, nonspecific gastroenterological manifestations. Specific symptoms - Dühring's dermatitis herpetiformis - in 1 person, diarrheal syndrome, steatorrhea, defects in tooth enamel were observed only in 4 children. According to the results of a laboratory blood test, anemia was detected in 2 people, and 6 more had a latent iron deficiency. Densitometry performed in 5 patients revealed a decrease in bone mineral density in 1 patient. Among serological tests, the determination of antibodies to tissue transglutaminase  IgA (13 people) was most frequently used. Also, in 3 people, antibodies to deamidated gliadin peptides and to endomysium were determined, in 6 people - to gliadin  IgA ,  . In 13 out of 17 children, a morphological study of biopsy specimens was used, classification according to the Marsh Oberhuber system  was used in 8 cases. Genetic markers were determined in 6 children, they were not found in 1, DQ 2 type was detected in 3 , DQ 8 in 1, both types were found in 1. 

Conclusion: The latest 2020 ESPGHAN guidelines for diagnosing celiac disease are underused, with a significant advantage of reducing the invasiveness of diagnosis. It is necessary to increase the awareness of physicians about risk groups, clinical forms and the consistent use of serological tests.

Молодежный инновационный вестник. 2023;12(S2):312-314
pages 312-314 views


Gabbasova A.M.


The article considers a hereditary disease attributed to the group of ciliapathies. Cartagenera syndrome (SC) is manifested by chronic bronchopulmonary pathology, inflammation of the sinuses and, in half of cases, inversion of internal organs. The disease is based on a violation of the synchronicity of movement and mobility of the ciliary epithelium. The aim of the study was to describe a clinical case, substantiate the methods of diagnosis of this syndrome according to the scientific literature. The research material was the medical history of a child undergoing examination and treatment at the Children's Clinical Hospital of the N.N. Burdenko VSMU, literary sources of scientific electronic library databases. Results. A clinical case of SC in a 4-year-old child is described. There were complaints of coughing with the release of purulent sputum. During physical examination, the patient's moderate-severe condition, shortness of breath, signs of chronic respiratory failure (shortness of breath, pallor, acrocyanosis) attracted attention, wet wheezing of various sizes was heard during auscultation of the lungs. The patient underwent a clinical, laboratory and instrumental examination, which revealed the reverse location of the internal organs, signs of a chronic inflammatory process in the lungs and sinuses of the nose. Conclusions. The symptoms of pathology are nonspecific, superimposed on other common respiratory diseases. To date, the detection of ultrastructural defects in the cilia by microscopy of a biopsy of the bronchial mucosa and/or nose is more significant, and the basis of diagnosis is the detection of gene mutations. In the clinical case described by us, in the absence of the possibility of using these methods of laboratory diagnostics, the diagnosis of the child was made only at the age of 4, already with a complicated course of the disease.

Молодежный инновационный вестник. 2023;12(S2):314-316
pages 314-316 views


Durneva V.S.


RELEVANCE. Due to the growing flow of false and controversial information, the growing distrust of vaccination, it is difficult for parents to make a choice “for” or “against” vaccinations for their children, so it is important to establish the main reasons for temporary or categorical refusals of vaccination by parents [1].
TARGET. To analyze the main reasons for parents' refusal to vaccinate children aged 0 to 5 years.
MATERIALS AND METHODS. The study was conducted on the basis of the BUZ VO "VGKP № 1" of the children's polyclinic No. 2. The object was 70 outpatient cards of children from birth to 5 years and a survey of their parents/legal representatives. Statistical, descriptive research methods, questioning, analysis were used.
According to the gender structure, there are 41 boys (58.6%), girls - 29 (41.4%). By age from 0-1 years old - 10 (14.29%) children, 1-3 years old - 25 (35.71%), 3-5 years old - 35 (50%). Physical development (PD) in patients at the time of the study: 54 (77.14%) had an average harmonic PD, 9 (12.86%) - above average, 7 (10%) - below average. 46 (65.7%) families have the first child, 24 (34.3%) have older children, where 13 (54.4%) are vaccinated, and 11 (45.6%) are partially vaccinated or not vaccinated at all. 62 (88.57%) parents were vaccinated in childhood, 8 (11.43%) were not. 64 (91.43%) parents learned about professional vaccinations from health workers, 6 (8.57%) - from other sources. When assessing the reasons for the refusal of parents from professional vaccinations, the children were divided into 2 groups: 1st - 24 children (34.3%) - not vaccinated, 2nd - 46 children (65.7%) - partially vaccinated. In the 1st group, 10 parents (41.7%) refused to vaccinate their children due to fear of complications, 5 (20.8%) - had an opinion about the uselessness of vaccination, 8 (33.3%) - considered the composition of the vaccine doubtful, 1 - refusal on religious grounds. In the 2nd group, 24 (52.17%) parents partially refused vaccination due to fear of complications, 10 (21.74%) - due to the presence of post-vaccination complications, 7 (15.22%) - were not satisfied with the composition of the vaccines , 5 (10.87%) experienced the ineffectiveness of the previous vaccination (for example, against influenza).
CONCLUSION. Vaccination at the present stage remains an important tool in the fight against infectious diseases. Health workers need to conduct activities to raise awareness of parents about preventive vaccinations. Each case of refusal to vaccinate must be justified from the standpoint of a doctor. The joint work of medical professionals with parents, considering the reason for the refusal, will minimize unreasonable refusal of vaccination and prevent many infectious diseases.

Молодежный инновационный вестник. 2023;12(S2):316-319
pages 316-319 views


Kovylova I.M.


RELEVANCE. Breastfeeding (LF) is the best form of nutrition for children from birth. With breast milk (GM), the child receives a complex of protective factors, hormones, immunoglobulins. Refusal of breastfeeding and reduction of its duration leads to increased morbidity and mortality in children [1].
TARGET. Conduct an analysis of the awareness of medical workers in the city of Voronezh on breastfeeding issues.
MATERIALS AND METHODS. The study was conducted on the basis of the BUZ VO "VGKP No. 1" of the children's polyclinic No. 2. The object was 72 questionnaires of medical workers in the city of Voronezh. Research methods: statistical, descriptive, questioning, analysis.
RESULTS. 72 questionnaires of medical workers in Voronezh were analyzed. Among the respondents, more than half (63.9%) are doctors (of which 46.2% are pediatricians, 53.8% are obstetricians-gynecologists), and 36.1% are nurses. The mean age is 44.5 years (SD 12.7 years). The average work experience in the specialty is 22.5 years (SD 14.6 years). To the question of the questionnaire: "HB reduces the risk of developing diseases" - 90.3% of the respondents answered - intestinal infections, 58.3% - ARVI, 36.1% - bronchial asthma, 25% - pneumonia, 19.4% - diseases of the middle ear . The fact that breastfeeding reduces the risk of developing obesity in children is considered by 88.9% of respondents, diabetes mellitus - 61.1%, bronchial asthma - 51.4%, cardiovascular diseases - 43.1%, arterial hypertension - 31, 9%. All respondents noted that breastfeeding reduces the risk of developing breast cancer in women, 48.6% - reduces the risk of ovarian cancer, 25% - anemia, 15.3% - osteoporosis. Not all respondents know about the WHO/UNICEF initiative "Baby Friendly Hospital" - 86.1%. “Which organizations take part in the initiative?”: 93.1% of people answered - children's polyclinics, 69.4% - maternity hospitals, 51.4% - antenatal clinics. Only 13.9% of people recommend breastfeeding until the age of the child 6 months, up to 12 months. - only 37.5%, up to 18 months. – 25%, up to 24 months. – 13.9%, 24 or more months. - 9.7%. Exclusively HB is advised up to 1 month. the life of a child is only 20.8% of health workers, up to 4 months. - 34.8%, up to 6 months. – less than half (44.4%). 8.3% consider supplementing water with exclusively HB, and the vast majority (91.7%) do not recommend it. The methods for assessing the sufficiency of GM in 33.3% of respondents is control weighing, in 52.8% - the assessment of monthly weight gain, in 13.9% - the assessment of the number of urination per day. Sources of medical knowledge: study at a medical school/university - 77.5% of respondents, advanced training - 59.7%, popular science literature - 58.3%, conferences - 27.8%, Internet - 19 ,4%.
CONCLUSION. Questionnaires of medical workers allow to identify problematic points in the issues of counseling mothers on breastfeeding and determine topics for further training. Increasing the level of knowledge, compliance with the Breastfeeding Policy will improve breastfeeding indicators, which will lead to improved health of the child population.

Молодежный инновационный вестник. 2023;12(S2):319-321
pages 319-321 views


Krutskikh E.Y., Astanina E.D., Chertok E.D.


Relevance: Primary immunodeficiency (PID) is a severe genetically determined disorder in the
immune system. Among the main manifestations are severe bacterial, fungal and viral infections
with damage to many organs and onset in the first 2-3 years of life, which can lead to death. The
main method of therapy is the timely transplantation of hematopoietic stem cells (HSCT) with an
efficiency of up to 80%. However, this is possible only in case of early diagnosis.
Purpose: To collect an anamnestic data, to evaluate clinical, laboratory and instrumental results
to confirm the diagnosis of PID.
Methods: A study of the medical documentation of a child aged 1 year 2 months, who was
repeatedly hospitalized in inpatient medical institutions in Voronezh, was conducted. Attention
was paid to the pregnancy and childbirth peculiarities in the mother, the morbidity of the child,
clinical symptoms, the results of laboratory and instrumental tests, including the parameters of
the immunological status.
Results: The patient showed signs of PID according to WHO, and therefore an additional
immunological examination was carried out. The development of sepsis with the release of
atypical infectious agents and meningoencephalitis, multiple organ lesions, and the lack of
sufficient effect from combination therapy suggested TKIN, which was confirmed by the KREC
and TREC results. The onset of severe disease after the age of 1 year can be explained by the
absence of BCG vaccination. The main method of treatment is HSCT. It is currently impossible
to resolve the issue of HSCT in our patient, since there is an ongoing serious bacterial-viral-
fungal infection that requires long-term antimicrobial, antifungal and anti-tuberculosis therapy.
The prognosis for the patient is doubtful due to the high risk of recurrence of the infectious

Молодежный инновационный вестник. 2023;12(S2):321-323
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Lanchuk M.A., Yudina N.B., Chertok E.D.



Relevance: Immune thrombocytopenia is serious problem of children hematology. Persistent and chronic forms of disease develop more often now days that require knowledge of risk factors and search new possibilities of treatment.

Purpose: To learn the peculiarity of immune thrombocytopenianow days.

Methods: We have examined medical documents of 95 patients in age from 6 months to 18 years. We have took attention to the time of diagnosis confirm from the fist clinical symptoms, all clinical symptoms and level of plates in the onset of disease, possible triggers of disease, duration of disease and effectives of different treatment methods.

Results: The majority of patients had typical skin hemorrhage syndrome (petechia and ecchimosis), nose and uterine bleeding.Severe and very severe thrombocytopenia was registered in 95% of patients. The tendency to increase persistent and chronic forms was found in 73% of children. Viral and bacterial infection wasthe most important triggers factors as well as allergy, vaccination and different drugs. H. Pilory infection and helmintosis were confirmed as trigger factors in patient with persistent and chronic disease.

 Conclusion: therapy according to modern protocol has good efficacy and leads to control of diseases. Puls-therapy of high dose of corticosteroid and intravenous immunoglobulin recommends as a “fist line” of therapy. Stimulators of thrombopoetin activity can be recommend in cases of lack efficacy.

Молодежный инновационный вестник. 2023;12(S2):324-326
pages 324-326 views


Leonova V.V., Леонов S.A.


Relevance. Gastroesophageal reflux (GER) is a retrograde throwing of stomach contents (hydrochloric acid, digestive enzymes and sometimes bile) into the esophagus, which leads to the appearance of symptoms. The scale of the problem dictates both social and economic negative effects for the society of developed countries. This determines the relevance of studying gastroesophageal reflux disease in children.
Objective: to study clinical and instrumental manifestations of gastroesophageal reflux disease in children.
Materials and methods of research. The study was conducted on the basis of the "Healthy Child" medical center in Voronezh in the period from September to December 2022. During the examination, all children were examined by a gastroenterologist and ultrasound of the stomach with a water-siphon test. During the inspection , the following: clarification of complaints, collection of anamnesis, general examination and special status.
The results of the study. Prolonged regurgitation up to a year is an important factor in the formation of GER. For all the examined children, GERD was not the only disease from the gastrointestinal tract, but was most often combined with gastritis (gastroduodenitis) and constipation, and among other concomitant diseases, obesity plays an important role. Among the clinical manifestations, in most cases there were complaints of extraesophageal manifestations, while the younger the child, the more often these complaints occurred. The data of ultrasound examination of the stomach in all cases were compared with anamnestic factors and clinical examination, which makes it possible to use this method of diagnosis of the disease everywhere.
Conclusions. Gastroesophageal reflux disease occurs in almost any age group, and most often the onset of the disease occurs at the age of up to 6 years, from which it can be concluded that at the present stage there is a "rejuvenation of the disease". Due to various clinical manifestations, gastroesophageal reflux disease can occur "under the masks of various diseases", which makes it difficult to make a timely diagnosis and delay rational therapy. which requires a cautious attitude regarding this disease not only pediatricians and gastroenterologists, but also doctors of other specialties.

Молодежный инновационный вестник. 2023;12(S2):326-329
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Mazurenka N.N.


Relevance. Duodenogastric reflux (DGR) is a pathological condition caused by a violation of the motor and evacuation function of the gastroduodenal zone and is characterized by spontaneous regularly repeated throwing of duodenal contents into the stomach cavity, which leads to functional disorders and / or damage to the gastric mucosa with the development of catarrhal, erosive and ulcerative changes [1] . With GHD, prolonged contact of refluxate with the mucous membrane leads to the development of inflammatory changes characteristic of a special form of chronic gastritis - chemical-toxic-induced or type C gastritis [2]. In children, there are no large-scale studies on the problem of GHD, a comprehensive study of morphological and endoscopic manifestations has not been carried out, and criteria for GM damage depending on the presence of Helicobacter pylori (H.pylori) have not been developed. Target. To substantiate the use of a modified formula for calculating the chemical gastritis index for diagnosing H. pylori infection in children with GHD. Material and methods. The study included 120 patients with GHD aged 0 to 18 years (59 boys, 61 girls), the median age was 14 (11; 16) years, who were hospitalized at the health care facility "Vitebsk Regional Children's Clinical Hospital" for period 2015-2021 The children were divided into groups depending on the presence of H.pylori: group G1 - a group of patients with GHD without H.pylori (n=75), group G2 - a group of patients with GHD with the presence of H.pylori (n=45). The children underwent esophagogastroduodenoscopy (EGDS), biopsy specimens of the antrum of the stomach were taken with a morphological assessment. Based on the modified formula of chemical gastritis and morphological parameters, the index was calculated to determine the optimal value for screening for H. pylori infection in children with GHD. The results of the study allow us to conclude that in patients with GHD without H. pylori, when using the modified chemical gastritis index formula, an indicator of less than 6 was informative, and in GHD with H. pylori, the best combination of sensitivity (64.44%) and specificity (92, 56%) gives an index value of 4 (p=0.008). Conclusion. If the researcher, when calculating the index of chemical gastritis in children with GHD, using the modified formula, receives values ​​of 4 or less, he should more carefully carry out a diagnostic search for H. pylori. The use of a modified formula for calculating the index of chemical gastritis for children with GHD will allow screening for the presence of H. pylori in order to improve the quality of treatment and prevent the development of possible complications.

Молодежный инновационный вестник. 2023;12(S2):330-333
pages 330-333 views


Markin D.A., Klokova E.I., Kolomatskaya V.V.


Relevance: Cystic fibrosis (CF) is an orphan genotypically polymorphic hereditary disease with autosomal recessive transmission. CF is caused by a mutation in the CFTR gene, is characterized by damage to the exocrine glands, and has a chronic severe course with an unfavorable prognosis. This disease is characterized by a progressive chronic course, can lead to early disability and death. This leads to a decrease in all components of the quality of life, namely the physical, emotional, social and role functioning of the child.
Purpose: to assess the quality of life of children with cystic fibrosis in the Voronezh region.
Materials and Methods: Statistical analysis of 3-part questionnaire data using Microsoft Office Excel. Questions of the questionnaire touched upon aspects of the underlying and concomitant diseases, assessment of the quality of physical and moral health, quality of life on the part of children and their parents. The study was conducted at the bases of the "Regional Center for Cystic Fibrosis in Voronezh", BUZ VO "Regional Children's Clinical Hospital No. 2".
Results: we surveyed 24 patients aged 2 to 18 years, the largest number of children in the age group 11-14 years (34%). Children with CF have comorbidities in 66.7% of cases. Up to 60% of children suffer from acute respiratory infections 3-4 times a year, which increases the frequency of taking antiviral and antimicrobial drugs. In this regard, 50% of children are forced to study at home, up to 60% of children cannot study in additional sections. 50% of parents are not satisfied with the health of their children, and only 16.7% note a deterioration in their condition compared to last year. 16.6% of children are not satisfied with family relationships. 25% of children say that their health conditions prevent them from spending time with family and friends. Children with CF have a special attitude towards themselves from their peers in 8% of cases, and from teachers in 45% of cases. 41.6% of parents are satisfied with the availability of medical care. More than 80% of parents say that the quality of life of their child will improve the provision of original drugs.
Conclusion: assessment of the quality of life of children with CF is important in pediatrics. Particular attention should be paid to the problems of socialization and adaptation of children in society. Continuous provision of patients with new drugs will help improve the quality of life of children. We predict an improvement in the quality of life of CF patients due to the introduction of targeted therapy.

Молодежный инновационный вестник. 2023;12(S2):333-335
pages 333-335 views


Razuvaeva Y.Y., Didenko A.V.


Relevance. Health is a holistic multidimensional dynamic state that develops in the process of realizing genetic potential in a specific social and environmental environment and allows a person to exercise his biological and social functions to varying degrees. At the moment, anxiety disorders are the most common mental disorders that begin in childhood, according to statistics, the prevalence of which ranges from 10 to 30%. The purpose of the study: to assess the level of personal anxiety in Voronezh adolescents. Materials and methods. A survey of 104 teenagers was conducted in the period from September to December 2022. Gender, age, social status, the presence of bad habits, the quality of sleep and rest, as well as the level of anxiety were assessed according to the questionnaire of A.M. Parishioner. Results. As a result of the conducted research, it can be concluded that half of adolescents do not observe the sleep regime, and a third do not observe the work and rest regime, more than half enter into conflicts with relatives, teachers and peers, which, with systematic abuse, can increase the level of anxiety. Most teenagers cope with stress and anxiety on their own, including some who abuse bad habits, but only a quarter of respondents have sought or are seeking professional psychological help. According to the questionnaire of A.M. Parishioner, the optimal level of anxiety was observed only in a third of adolescents. A significantly higher level of general, self-esteem and interpersonal anxiety is determined in the female sex. Conclusion. Thus, adolescents often experience social stress, fears, anxiety, which can have a negative impact on the health of students. In the correction of anxiety, a complex impact on the student plays a huge role, including the availability of professional psychological assistance.

Молодежный инновационный вестник. 2023;12(S2):336-338
pages 336-338 views


Rudakova A.A.


The purpose of the study: to create a diagnostic algorithm that would help a doctor of any specialty to suspect and not miss a child with stunting.
Materials and methods: the analysis of publications, manuals and educational literature on this topic was carried out, the most relevant approaches in the diagnosis and treatment of stunting in children were selected.
Results: the analyzed information was structured into a diagnostic algorithm that can be used in practice by a doctor of any specialty.
Conclusion: the chosen topic is multifaceted and broad. Growth retardation can be of various etiologies, so there is a wide variety of approaches to the treatment of stunting in children. Early diagnosis is of great importance for this disease, because hormone replacement therapy is carried out before the closure of growth zones, that is, if a child of puberty turns to the problem of stunting, in this case it will be almost impossible to help. Even if it is the beginning of puberty, there will not be enough time for full-fledged hormone therapy, which will not allow the patient to achieve average growth rates.

Молодежный инновационный вестник. 2023;12(S2):339-340
pages 339-340 views


Skripkina A.S., Chertok E.D.


Relevance: Inhaled corticosteroids (ICS) are considered to be the most effective drugs to achieve control of asthma, which help to improve pulmonary function and reduce hyperreactivity of the respiratory tract. However, specific side effects of the use of corticosteroids in the form of slowing the growth rate and development of candidiasis of the oropharynx are described.

Purpose: To evaluate the efficacy and safety of long-term use of ICS in children with asthma of prepubescent age.

Methods: 23 patients in age from 6 to 8 years received fluticasone furoate at a daily dose of 50 mcg once daily for a year. Monthly physical examination, monitoring of respiratory function, assessment of signs of oropharyngeal candidiasis and AST test (Asthma control test) were carried out. The effectiveness of treatment and the occurrence of adverse events were evaluated 3, 6 and 12 months after the start of therapy. The growth rate was calculated after 6 and 12 months.

Results: Monotherapy of inhaled corticosteroid fluticasone furoate during the year demonstrated positive clinical dynamics and improved respiratory function in patients with mild and moderate asthma. None of the observed patients showed signs of oropharyngeal candidiasis during the entire follow-up period. Isolated cases of mild exacerbation of the disease and acute respiratory episodes have been recorded, the frequency of which did not exceed that for the previous year. Also, the results of the study showed that long-term therapy with inhaled corticosteroids is not accompanied by the growth retardation of prepubescent patients.

Молодежный инновационный вестник. 2023;12(S2):340-342
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Sundeeva A.S., Chertok E.D.


Relevance: Asthma in children with allergic rhinitis is more severe with frequent relapses and long duration.

Purpose: To analyze the peculiarity of asthma n children with allergic rhinitis.

Methods: a research was conducted of 132 children suffer from asthma in age from 6 month to 18 year who had observation at Voronezh children pulmonology center. We have analyzed duration of disease, allergic reactions in family members, children’s allergens, asthma peculiarity and efficacy of basic therapy.

Results: We have registered increase of allergic rhinitis in children with asthma. Diagnostic process duration is from 2 months to 14 years. The majority of patients was examined by pediatricians as patients with frequent respiratory infections and has not received correct treatment. Increase level of eosinophils in hemogram and immunoglobulin E is not obligation for confirm the diagnosis. Level of ECP is more important as a diagnostic method of allergy. Asthma in children with allergic rhinitis has important peculiarities such as more frequent relapses and long duration of exacerbations.
Conclusions: Basic therapy according to modern protocols has good efficacy and leads to control of both diseases.

Молодежный инновационный вестник. 2023;12(S2):342-344
pages 342-344 views


Chetvernya A.M.


RELEVANCE. According to the WHO, annually in the world 15 million children are born prematurely, in Russia - 110 thousand. Prematurity is the leading cause of death in children under 5 years of age [1]. Among the most common risk factors for preterm birth are social, biological, clinical [2].
TARGET. To assess the health status of premature babies born to mothers with a burdened obstetric history in the early neonatal period on an outpatient basis.
MATERIALS AND METHODS. The study was conducted on the basis of the BUZ VO "VGKB No. 11", children's polyclinic No. 5. The object was 50 outpatient cards (form 112/y) of premature babies aged 0 to 4 years by random sampling. Statistical, descriptive research methods and analysis were used.
RESULTS. Of the 50 children studied, 27 boys (54%), girls 23 (46%). Of the 47 women, 44 (93.6%) had an independent pregnancy, 3 had induced IVF, 44 (93.6%) had a singleton, and 3 had a multiple pregnancy. Self-delivery - in 2 women, by caesarean section - in 45 (95.7%). Births in a row 1st in 29 (55.3%) women, 2nd - in 13 (27.7%) women, 3rd - in 8 (17%) women. By gestational age, newborns were distributed as follows (according to the WHO classification): late premature - 36 (72%) children, moderately premature - 4 (8%) children, deeply premature - 9 (18%) children, extremely premature - 1 child. According to the Apgar scale at 1 minute, 23 (46%) newborns had a score of 7 points, 24 (48%) - 4-6 points, 3 (6%) - 1-3 points. At the 5th minute, 38 (76%) children had 7-8 points, 12 (24%) had 4-6 points.
In the early neonatal period, preterm infants were noted to have: CNS damage in 44 (88%), cardiovascular system damage in 32 (64%), hyperbilirubinemia in 26 (52%), IUI –17 (34%), risk of IUI–26 ( 52%), respiratory disorders - 15 (30%), skin lesions - 9 (18%), urinary system - 8 (16%), eyes - 6 (12%), musculoskeletal system - 4 (8%), anemia - 8 (16%). All premature infants had comorbidities.
All women had a complicated obstetric-gynecological and somatic history. All women also had complications during pregnancy. Extragenital pathology was observed in 25 (53.19%) mothers, infections - in 20 (42.55%) mothers, gynecological diseases - in 17 (36.17%). Almost every mother had a combined pathology.
CONCLUSION. Complicated somatic and obstetric-gynecological anamnesis of pregnant women is the main risk factor for preterm birth, along with complications of this pregnancy. In preterm infants, in addition to frequent congenital pathology, immaturity of organs and systems, the incidence of somatic, surgical, and infectious diseases increases, which can lead to irreversible health problems in later life. In this regard, it is necessary to care for premature babies and regular monitoring in the catamnesis rooms.

Молодежный инновационный вестник. 2023;12(S2):344-346
pages 344-346 views


Iakovenko A.E.


The aim of the research is to examine the state of the parietal microbiome in children with ASD using gas chromatography-mass spectrometry of blood microbial markers, to determine the likely triggers of ASD in children with functional disorders of the gastrointestinal tract. 


Materials and methods. Small intestine microbiome was studied by chromatography-mass spectrometry of a dry blood drop (CMS according to G.A. Osipov). 39 children (1.5 - 10 years old) took part in the research. All children had stable functional gastrointestinal  disorders. The first group (26 children) included children without signs of autism and other psycho-neurological dysfunctions. Children from the second group (13 people) were previously diagnosed with ASD in accordance with CARS scale by a psychiatrist. Statistical data were processed on a PC using the STATISTICA 12 software package. ROC analysis was performed. 


Results. The state of the microbiome in the first group significantly differs from the second group. Children diagnosed with ASD show predominance of Clostridium ramosum, Clostridium perfringens, Eggerthella lenta and Nocardia asteroides. Moreover, the amount of Clostridium ramosum in children diagnosed with ASD as well as suffering from functional disorders of the gastrointestinal tract, in more than 75% of cases exceeds the reference values (2000 10 * 5 cells / gram). The average value of Clostridium ramosum for this group is 3494 10*5 cells/gram. Thus, the study of the parietal microbiota in children with signs of autistic disorders can be used as a method of additional diagnostics. 

Conclusions. One of the most significant differences in microbiome of autistic and neurotypical children with gastrointestinal symptoms is the overgrowth of Clostridium ramosum, which may be used as a factor in the early diagnosis of ASD in children.

Молодежный инновационный вестник. 2023;12(S2):347-350
pages 347-350 views

Профилактическая медицина


Amelina P.A.


Relevance. Myopia is one of the most important problems of modern ophthalmology. This problem is especially relevant for students and schoolchildren, due to the peculiarities of the educational process. Therefore, the control of the progression of myopia and the prevention of myopia are important not only for healthcare in Russia, but throughout the world. Visual impairment at a young age has lifelong consequences, both for the person himself and for his family. This affects the development of a person, his education and skills, requires the care of a family and specialists. Low vision affects both his abilities and social prospects.
Target. Evaluation of the loss of skills and identification of the dependence of the deterioration in the quality of life in students from 20 to 22 years old with various degrees of myopia, with a directed choice of optical correction in a certain age group “Looking into the Future” using the approved IVI-C questionnaire. Evaluation of the optimal options for optical correction for each degree of ametropia.
Materials and methods. A group of 30 students of VSMU was chosen. N.N. Burdenko, out of 11 men and 19 women from 20 to 22 years old. The group included people with different degrees of myopia - weak (50%), medium (33%), high (17%). Among the selected students, a survey was conducted according to the tested IVI-C questionnaire, containing 30 questions of the type “Do you confidently get to the university, do you confidently use public transport?” and others with answer options: Always, Almost always, Sometimes, Almost never, Never, No, for other reasons.
Results. The data obtained during the survey were converted into points. The results were plotted in a chart that showed that the average score that students scored without optical correction was 50 points, and those using optical correction such as glasses and lenses was 85. Also, data analysis showed that the average score when questioning students with a weak degree myopia was 78.5, with an average degree of 63.2 and with a high degree of 57.0.
Conclusion. In the course of the study, the relationship between visual impairment and the quality of life of students without optical correction was confirmed using the approved IVI-C questionnaire. Identified problems can be solved with the help of optical correction, such as wearing eye lenses and glasses, as well as performing refractive surgery. The optimal options for each degree of ametropia were identified and conclusions were drawn that spectacle correction is the optimal and universal method of optical correction for each degree of myopia.

Молодежный инновационный вестник. 2023;12(S2):351-353
pages 351-353 views


Bokov D.A., Fursova E.A., Kochetkova I.V., Tyunina M.V.


Relevance. In today's world, chronic non-communicable diseases (CNIDs) are leading among diseases and causes of mortality. To prevent the development of CNID and to reduce mortality from them, it is necessary to timely identify risks among the population, carry out preventive measures to identify them and disseminate information about risk factors in society. Preventive measures should be carried out among all groups of the population, including among young people, whose structure includes an extensive group of students. Purpose. Analyze the results of sociological studies on the prevalence of risk factors for the development of KhNIZ among students of the N.N. Burdenko FSBEI HE. Materials and methods. The study was carried out on the basis of FSBEI HE VGMU named after N.N. Burdenko during 2022 using sociological surveys among students. The survey was conducted in the form of a student questionnaire, a total of 820 questionnaires were processed, of which 25% of men and 75% of women filled out. The survey was conducted on the following topics: "Movement is life" - 109 people, "Alcohol" - 166 people, "Smoking" - 164 people, "Attitude to proper nutrition" - 162 people, "Attitude to stress" - 136 people, "Sex education." Results. Based on the data obtained during sociological surveys, it can be concluded that out of 100% of the respondents: they drink alcoholic beverages - 80.1%, smoke -37.2%, are overweight - 17.8%, constantly or periodically experience stress - 88.2%, lead an inactive lifestyle - 48.6%, feed incorrectly - 19.8%, have digestive diseases - 27.8%. Conclusion. Alcohol, smoking, poor diet, low physical activity, stress - risk factors for the occurrence of CNID in students studying at the N.N. Burdenko FSBEI HE VGMU. Analyzing the state of the health problem, it can be seen that a poor attitude towards one's health entails negative consequences. The protection and promotion of health is mainly determined by lifestyle. To reduce the likelihood of developing chronic non-communicable diseases, it is recommended to carry out active educational work on the formation of a healthy lifestyle. Regular physical activity, proper nutrition, lack of bad habits can protect health.

Молодежный инновационный вестник. 2023;12(S2):353-355
pages 353-355 views


Budanova V.A., Vakin M.A., Kochetkova I.V., Fursova Е.A., Tyunina M.V.


Relevance. In modern society, the fight against the spread of such a socially significant problem as alcoholism has been going on for many years.

Objectives: to study the attitude of young people to alcohol consumption, to study the motivation for alcohol consumption among young people, to identify the degree of prevalence of alcohol consumption among students of the Burdenko VSMU, to analyze the data obtained based on the survey, to provide recommendations for solving the problem of excessive alcohol consumption

Materials and methods.
The object of our research were students of the Burdenko VSMU of the Ministry of Health of the Russian Federation in Voronezh. The method of conducting is a survey using an anonymous questionnaire . The materials for studying this problem were the study of popular science literature, the collection of information via the Internet (ICD-10, medsoftpro).

Out of 100% of the surveyed students, 80.1% drink alcoholic beverages; respondents prefer alcoholic beverages such as wine, vermouth, champagne (55.7%), beer is in second position (47.1%), they also use light low-alcohol cocktails (41.4%), they will not give up strong alcoholic beverages (37.1%). 76.5% of respondents know about the dangers of alcohol. However, 22.9% believe that the harm of alcohol to the body depends on the amount of alcohol consumed.

Alcohol is a risk factor for the occurrence of CNID in students of the Burdenko State Medical University of Voronezh.

Молодежный инновационный вестник. 2023;12(S2):355-357
pages 355-357 views


Gurov V.R., Abramova Y.A., Kochetkova I.V., Fursova E.A.


Relevance: The lack of sexual education of children and adolescents in schools and families, one of the most important problems of modern society, the consequence of which was the earlier sexual development of the younger generation. The shortage of specialists who are able to find an individual approach to the child and correctly convey the necessary information: to tell about sexual education, to warn against rash actions, under the influence of society, also lead to this problem. It is proved that the high level of sexual education of adolescents significantly reduces the number of unprotected sexual relations, as well as the number of early pregnancies, abortions, sexually transmitted diseases. In our country, the issue of sexual education of children and adolescents is more acute than ever. This is proved by the fact that Russia occupies one of the first places in terms of mortality and development of pathology associated with abortions in minors.
The purpose of the work. To raise awareness of the need to introduce sex education in childhood and adolescence, based on the responses of students, when analyzing the questionnaire "Sex Education" provided to them.
Materials and methods. An anonymous survey of students of the Voronezh State Medical University named after N.N.Burdenko of the Ministry of Health of the Russian Federation was conducted; 83 students aged 17-25 years were interviewed, while the largest coverage among all respondents was among women (73.2%); Google Forms software was used.
Results. Out of 100% of respondents, 81.9% consider it necessary to introduce a special subject "Sex education" in school. Students consider the following topics to be the most relevant: prevention of sexually transmitted diseases (97.6%); pregnancy prevention (79.5%); anatomy, physiology and hygiene of the genitals (77.1%). In the family, 30.1% of respondents received sex education; at school – 6.10%; on the street – 10.8%; used special literature to gain knowledge -9.6% of respondents; somehow it happened by itself – 43.4% (conversations with peers, literature, the Internet, etc.). At the age of 14-16, 9.6% of the surveyed students began to have sex. 35% of students do not know what STI means. Unfortunately, 37.3% of respondents consider the number of sexual partners per year to be the norm – as much as you like, the main thing is to protect yourself.

Молодежный инновационный вестник. 2023;12(S2):358-360
pages 358-360 views


Дубинина M.S.


Annotation. The pandemic of a new coronavirus infection, which began its spread in 2019, the geopolitical conflicts taking place during its time, man-made and spontaneous events, including the special military operation that began in February 2022, are accompanied by serious social upheavals and can significantly affect the risk factors for the spread of STIs. A hypothesis has been put forward: what is the dynamics of the incidence of sexually transmitted infections in 2019-2021 in connection with the social upheavals of recent years and their characteristic features for society? it may differ from their trends traced from 2014 to 2019. Objective: to study the peculiarities of changes in the age and social structure of newly identified cases of bacterial sexual infections in the Kursk region during the coronavirus pandemic. Results. Cases of diagnosis of syphilis and gonorrhea in minors during the period under review were noted only in 2019, when their share in the structure of primary morbidity was 3.3%. The social group for which in 2019 – 2021 the largest number of primary cases of bacterial STIs accounted for, there was an unorganized contingent – not studying and not having an official place of work. Their share has consistently decreased from 51.7% to 46.4%. Conclusion. Changes in the social structure of primary morbidity are more significant and are characterized by an increase in the proportion of workers with a decrease in the proportion of students and the cessation of detection of gonorrhea and syphilis in schools.
Keywords: 78 coronavirus infection, sexually transmitted infections, syphilis, chlamydia.

Молодежный инновационный вестник. 2023;12(S2):360-362
pages 360-362 views


Dunayskaya A.A., Fursova E.A., Kochetkova I.V., Tunina M.V.


Goal. To identify the causes and manifestations of stress in medical university students, to evaluate various stress factors affecting students.

Methods. The object of the study were students of the Burdenko VSMU aged 17 to 28 years – 136 students. Anonymous questionnaires in Yandex-forms and automatic counting of results were used.

Results. During the survey of students, what in their opinion are the causes of stress and its characteristic manifestations, the following was revealed:intensive mental work, reduction of school debts in a short time, work with a huge amount of information that needs to be processed and filled in in a short period of time, as well as violation of the daily routine and, consequently, lack of sleep are the causes of stress.  Typical manifestations of a stressful state of the body are overeating and malnutrition, anxious thoughts, tremor of the hands, tachycardia, insomnia. Most students of higher educational institutions face these realities.

Conclusions. "All diseases are caused by nerves" this opinion has found confidence in the scientific society. Currently, the claim that stress associated with the educational process is a risk factor that has a negative impact on such systems as: cardiovascular, nervous, immune systems and psycho-emotional state; has strong evidence. In the event of a stressful situation, in addition to stress, accompanying factors affect the deterioration of students' health: the use of tobacco, alcohol and narcotic products, which, as the student believes, will help him to relieve tension and improve mood.

Молодежный инновационный вестник. 2023;12(S2):362-364
pages 362-364 views


Zherebilova A.P., Bakhmeteva J.V., Kochetkova I.V., Fursova E.A.


Relevance: this article touches on one of the important problems of modern youth - low physical activity. A passive lifestyle leads to the development of chronic diseases of the cardiovascular system, musculoskeletal system and other organs and systems.
Purpose: to assess the level of physical activity of students of the Voronezh State Medical University. N.N. Burdenko and, based on the data obtained, to identify possible ways to solve physical inactivity among students.
Materials and Methods: An anonymous survey of medical university students was conducted during 6 months of 2022. The questionnaire in the Yandex-form format consisted of 18 questions and two blocks: general and special. Statistical processing of the obtained data was carried out in Microsoft Excel 2007. Quantitative data are presented as a percentage.
Results: out of 100% of the students surveyed, in their opinion, lead an inactive lifestyle - 48.6%, do not go in for sports - 35.8% of students. The main reasons for not wanting to go in for sports, according to the respondents, are as follows: heavy workload at school and at home (68.5%), I can’t force myself (43.5%), there is no time (41.3%). Students currently assess their physical condition as poor (3.7%), worse than average (15.6%), average (48.6%), fairly good (24.8%) and very good (7.3%). ).
Conclusion: the analysis of the survey conducted led to the following conclusion - many students neglect sports, which can lead to chronic non-communicable diseases. The conducted research and the data obtained can help to study this problem in more detail and understand how to draw the attention of students to their health and to an active lifestyle.

Молодежный инновационный вестник. 2023;12(S2):364-366
pages 364-366 views


Lomonosova P.A.


Relevance: Due to the regular high psychological and nervous load during the training period associated with the study of a large volume of material in a short period of time, students of medical universities may experience a decrease in performance. As a result, the question of a non-drug solution to this problem is acute. One of these is a course of speleotherapy. Objective: to study the students' performance before and after completing the course of speleotherapy using variational chronoreflexometry. Materials and methods: For this purpose, 26 students aged 17-21 were placed in a speleocamera for 1 hour for 10 days during a stable load period (October-November). Prior to the start of the course, on the 3rd and 10th days of the speleocourse, variational chronoreflexometry was performed using the M.P. Moroz technique for the right and left hands. The results showed that the performance of students varies slightly, simple sensorimotor reaction becomes longer, the main performance indicators tend to increase. Conclusion: the data obtained allow us to consider speleoclimatotherapy as a promising non–drug method of preventing performance, and variational chronoreflexometry as a good method of its evaluation.

Молодежный инновационный вестник. 2023;12(S2):375-377
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Polygina A.F., Kochetkova I.V., Fursova E.A., Tyunina M.V.


Observance of a healthy lifestyle, and in fact Orthodox, preserves a spiritual person's moral and physical health, prolongs life and creativity, gives a sense of contentment and fullness of life, that is, what we call happiness – joy, fullness and meaningfulness of spiritual life, individual health, absence of chronic diseases, catastrophic disasters, insurmountable suffering and the possibility of realizing creative potential

Молодежный инновационный вестник. 2023;12(S2):380-383
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Ponkratova T.V., Ryzhikh K.A., Kochetkova I.V., Fursova E.A.


Relevance. In 2016, more than 1.9 billion adults over 18 were overweight, according to WHO. Of these, over 650 million are obese and 462 million are underweight. According to the Russian Ministry of Health, in 2019, 517.3 thousand people were diagnosed with obesity for the first time in the country, which is 13.7% higher than in 2018. The problem of excess weight is becoming more and more urgent for young Russians, who are deluded about the balance of their diet.

Purpose. To identify the nutritional characteristics of respondents with subsequent assessment of anthropometric data and determine the prevalence of overweight and obesity, as well as BP variability among students of the Voronezh State Medical University. N. N. Burdenko.

Materials and methods. In total, the study involved 162 student volunteers of the Faculty of General Medicine, Pediatrics, Pharmaceutical, Dental, Nursing, Medical and Preventive at the age of 18-25 years. The socio-demographic characteristics of students were obtained using anonymous questionnaires, BP recording and anthropometric measurements with BMI calculated based on objectively measured data conducted by researchers during the fall semester of 2022.

Results. In the process of analysis, out of 162 participants, 2 groups were determined according to BMI deviation: 32 people with overweight and 23 with its deficiency. As a result of blood pressure measurement, 13 students had high normal blood pressure, 17 students were included in the group for AH of the 1st degree, and 5 students were included in the group for AH of the 2nd degree. At the same time, during the survey, it was found that among all those surveyed, 96.3% consume harmful foods in their diet.

Conclusion. As part of the study, it was possible to find out that students of the  medical university have errors in nutrition. The food they eat is high in fat and low in vitamins, leading to a rapid increase in body weight, which serves as a breeding ground for the further development of NCDs in this population. 

Молодежный инновационный вестник. 2023;12(S2):383-386
pages 383-386 views


Sidnina I.S.


Relevance. Occupational diseases are registered annually and have a significant impact not only on an individual employee and his family, but also on the population as a whole, which is why this topic deserves close attention. The purpose of the study was to analyze the professional incidence of the population of the Russian Federation and the Voronezh region for 10 years. Materials and methods. The materials for study were state reports, accounting and reporting forms of the Office of Rospotrebnadzor and the Center for Professional Pathologies of the Voronezh Region, data from scientific publications. The study was conducted using a retrospective epidemiological analysis method. Results. During the study, a tendency was established to reduce the level of occupational morbidity in the Russian Federation and in the Voronezh region. Regions and areas with the highest levels of occupational pathology compared to the average long-term indicators in other regions were identified. The structure of occupational diseases was analyzed by gender, work experience, influencing factors and the main causes of occupational disease. Conclusion. It was established that the most significant risk group is men who have more than 20 years of work experience and are subject to the influence of physical factors. An increase in acute occupational diseases in 2020-2021 was noted, due to an increase in the number of sick women, mainly health workers.

Молодежный инновационный вестник. 2023;12(S2):390-393
pages 390-393 views


Trufanova S.D., Myalkina S.A.


The relevance. COVID-19 is one of the most significant threats that has been encountered with regularity in recent times. In a pandemic, the frequent occurrence and prevention of diseases is especially common thing. Necessary knowledge and skills allow to reduce the incidence and protect you from infections.

The purpose of the research. Assessment of awareness on current issues of a new coronavirus infection among students of the Voronezh State Medical University. N. N. Burdenko.

The methods. A voluntary anonymous survey of 218 students of the Voronezh State Medical University was conducted. N. N. Burdenko online with the execution of the "Yandex-form". Methods of epidemiological analysis were applied.

The results. The study found that the majority of students had a coronavirus infection (72.5%), of which the vast majority (97.3%) had a mild or severe course of the disease. 2.7% of respondents applied for medical care with hospitalization. Common symptoms were fever and cough. The importance of preventive measures in relation to the likelihood of COVID-19 incidence among students is 80.3%. Reliable representatives between the groups on the ways of transmission by faculties were not identified (p>0.05). A high level of vaccination of students against NCI was established (70.2%), more than half of the respondents did not get sick after the vaccine. Among the respondents, there is a high awareness of the understanding of “stigmatization”.

The conclusion. During the research, we managed to define the knowledge of VSMU students about the questions specific and nonspecific prevention of NCI, as well as the nature and prevalence of the spread of infection. An analysis of students' awareness of stigmatization has shown that 10.1% of respondents identified discrimination towards them.

Молодежный инновационный вестник. 2023;12(S2):393-396
pages 393-396 views


Zatsepina I.V., Fursova E.A., Kochetkova I.V.


Smoking is one of the most important health problems. Smoking is a leading risk factor for the development of non-communicable diseases. NCDs, in turn, cause more than 2/3 of deaths in developing countries. The World Health Organization has been creating and implementing a lot of anti-smoking projects for many years. Many countries promote tobacco control as a key health priority [1]. Unfortunately, smoking tends to spread among the young population. The spread of smoking among medical students deserves special attention. They, as future doctors, should set an example of a healthy lifestyle for others, especially for smoking patients. The aim of the study is to assess the prevalence of smoking among students of the Medical University of VSMU named after N. N. Burdenko. The research method is an anonymous survey. 164 people took part in it. Most of students want to quit a bad habit (56.1%) and this is mainly due to the desire to prevent the consequences (27.8%) and get rid of addiction (27.8%). In the set of questions about the distribution of electronic cigarettes: 77.4% of respondents support the problem of relevance, 42.7% are negative about the distribution of electronic cigarettes. From all of the above, it follows that smoking is not only a risk factor for the development of CNID in students, but also a factor in reducing the effectiveness of preventive work in the future.

Молодежный инновационный вестник. 2023;12(S2):366-368
pages 366-368 views


Sergeeva E.V.


Lyme disease plays an important role in the structure of infectious morbidity in the territory of both the city of Voronezh and the Voronezh region, and in the whole of the Russian Federation. Particularly relevant is the problem of the spread of tick-borne borreliosis in rural areas, since there is a constant increase in the infection rate of ticks with the pathogen. The carriers of Lyme disease are ticks Ixodes ricinus, the causative agents are Borrelia afzelii and Borrelia garinii. The incidence is seasonal - the highest increase in cases is observed in the warm season, especially in the summer season, which indicates the need to strengthen preventive measures in the season of rising incidence and monitor the activity of natural foci. The article presents the results of the analysis of the incidence in the Voronezh region, a list of preventive measures against pathogens, as well as a brief description of the epidemiology, etiology, pathogenesis, clinical manifestations, diagnostic methods and principles for the prevention of tick-borne borreliosis Given the urgency of this problem, a thorough analysis of the conditions under which human infection occurred and the effectiveness of preventive measures that currently exist and are aimed at preventing tick bites and, as a result, reducing the incidence of Lyme disease is necessary.

Молодежный инновационный вестник. 2023;12(S2):386-390
pages 386-390 views


Ivanilov K.D., Borodina E.A.


Relevance. Currently, in the healthcare system of the Russian Federation, much attention is paid to the issues of reproductive health of the population. A significant area of activity in this area is the fight against the spread of sexually transmitted infections (STIs) and the identification of factors that can form a responsible attitude of society towards this problem.

The purpose of the study is to determine the role of a burdened obstetric and gynecological history in the formation of attitudes towards the problem of sexual infections among the inhabitants of the Chernozem region.

Materials and methods. The results of an anonymous survey of women were used as research materials. The survey participants were 520 women aged 18 years and older who are under the supervision of obstetric and gynecological institutions of the 2-3 levels of the Kursk, Belgorod and Voronezh regions. The resulting summary of data was examined by implementing descriptive statistics methods with calculation of relative values.

Results. Most pregnant women are aware of STIs, but many of them do not have sufficient and reliable knowledge on this issue, as well as their partners. It was also found that not all women are aware of the real threat of STIs during pregnancy and who should be contacted if they are detected. Findings. The results of the study made it possible to draw conclusions about the need for a competent reorganization of educational and medical activities on the part of health and healthcare authorities.

Молодежный инновационный вестник. 2023;12(S2):369-371
pages 369-371 views


Kardashov E.A.


Relevance: Diseases of the cardiovascular and respiratory systems are widespread among the population. People of all ages suffer from these pathologies. For their treatment, it is necessary to have an idea about the effect of popular methods on the body of a healthy person. This study examines the effect of speleotherapy on the cardiovascular and respiratory systems in a healthy person. The study involved 27 student volunteers 1-2 courses of VSMU. Each participant was informed about the purpose of the study by signing an agreement to participate in the experiment. We studied the dynamics of blood pressure, pulse, oxygen saturation, lung capacity (VC), respiratory rate, anxiety, well-being, activity and mood of the study participants before and daily for 10 days after an hour-long speleoclimate session. The analysis of the obtained data was carried out using Excel and StatPlus Pro programs. Results and discussion. Analysis of the dynamics of the median pulse pressure showed a general decrease in the indicator. Analysis of the dynamics of the median heart rate showed a decrease in the rate on days 2 and 9. Minimum - on the ninth day, increase - on the 4th and 10th. It should be noted a general decrease in the indicator relative to the first day. Oxygen saturation during the course remained at a high level. Analysis of the dynamics of the median lung capacity showed a decrease on the fourth and eighth days. There was a general decrease in the index. The anxiety of the subjects tended to decrease by the end of the course of speleotherapy. There was an increase in well-being, activity and mood compared with the first day. Thus, in general, a positive effect of speleotherapy on the human body was revealed. When analyzing the data, gender differences in the effect of speleotherapy on the human body were observed. Conclusion. In the course of the study, the effect of speleotherapy on the body of a healthy adult was investigated. There was a decrease in blood pressure (BPs, BPd, BPp), heart rate (HR), lung capacity (VC) and anxiety, as well as an increase in well-being, activity and mood in the general group. Saturation was at a high level during the course. Sexual features of the impact of speleoclimate on the human body were revealed.

Молодежный инновационный вестник. 2023;12(S2):371-373
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Medinsky K.S., Amosha D.N., Baron A.S., Belchikov N.A.


Relevance. The young generation of the DPR is forming a new way of life, adaptation to the external natural environment, in which biologically harmful industrial products are constantly in large or small concentrations. Over the past nine years (2014-2022), two severe stress factors have been added: active military actions (civil war on the territory of Ukraine, ITS, bombing, destruction, fear of losing life), epidemiological situation of coronavirus infection. All this complex of factors has an impact on the health of the young part of the population during the period of puberty - adolescence of 14-17 years. Goal. To study the influence of exogenous factors on the prevalence of respiratory diseases among DNR adolescents. Materials and methods of research. The studies were conducted among the adolescent population (14-17 years old) living in the DPR. Results. The primary morbidity of adolescents with respiratory diseases in the conditions of active hostilities in the Donbass is in the pre-

Молодежный инновационный вестник. 2023;12(S2):377-380
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Kravtsova A.V., Kochenkova I.V., Fursova E.A.


Relevance: The topic is relevant, since CSDs occupy a leading place among the causes of morbidity and disability in most economically developed countries of the world. Diseases of the circulatory system are one of the main causes of death in the population. Of particular danger is the fact that the early stages of the disease. are practically asymptomatic.

Purpose: To identify the most effective prevention standards that can qualitatively reduce cardiovascular risks. Materials and methods: A comprehensive, multi-stage study was conducted, according to a previously developed plan. This retrospective study included medical examination data from 2014 to 2021.

Results: All patients were divided into 3 groups according to health groups.  The frequency of chronic non-communicable diseases (CNCD), as well as risk factors leading to diseases of the circulatory system, was identified and analyzed. The proportion of people with diseases of the circulatory system who are under dispensary observation in each medical organization of the Voronezh region was analyzed. In accordance with the data obtained, in order to improve the situation with the number of diseases of the circulatory system, preventive measures were proposed.

Conclusions: Thanks to the medical examination data, early detection and diagnosis of diseases of the circulatory system became possible. What makes the development and implementation of new, alternative measures a priority for preventive medicine.

Молодежный инновационный вестник. 2023;12(S2):373-375
pages 373-375 views


Yushko Y.N.


Relevance. In the 21st century, non-communicable diseases (NCDs) pose a serious threat to human health, as confirmed by the annual worldwide "premature" mortality of about 17 million people in the working-age population. In this regard, the importance of early diagnosis and timely prevention of significant behavioral risks, especially for the younger generation and young people, is increasing.
Purpose. The purpose of the study was to study behavioral risk factors among students of the Medical University of Minsk.
Materials and methods. The work uses the method of anonymous questionnaire using a specially developed questionnaire and subsequent assessment of the functional state of organs and systems, determination of significant behavioral risk factors affecting the prevalence of non-infectious pathologies. Statistical data processing was carried out using the STATISTICA 8.0 computer program.
Results. In the course of analyzing the results of the study, it was found that more than half of the students have a particular pathology, namely disorders of vitamin and mineral metabolism, cardiovascular diseases, diseases of the gastrointestinal tract and diseases associated with disorders of carbohydrate and fat metabolism. Among the cohort examined, 25% of non-smokers and non-drinkers. At the same time, the share of students who smoke and abuse alcohol was 33.3% of students. The correlation analysis between the presence of a combined nature of these risks and the state of health of students did not establish a statistically significant relationship between the factor and outcome characteristics (Chi-square criterion, χ²=0.897, p = 0.344). However, an assessment of the risk of NCDs among exposed and non-exposed BHMU students showed that the risk of health abnormalities in the group exposed to smoking and alcohol is higher than the probability of disease among those not affected by these factors (Re > Rne) 0.67 > 0.55.
Conclusion. Consequently, the combination of behavioral habits (tobacco smoking and alcohol) significantly affects the development of non-infectious pathology in the population. The present study found that if smoking and alcohol consumption are taken as a causal and preventable factor, a reduction in disease risk among risk factor-exposed BHMU students can be expected by 18% in the event that they quit smoking and abuse alcohol.
Молодежный инновационный вестник. 2023;12(S2):396-398
pages 396-398 views

Психиатрия с наркологией


Rogov . .


Relevance. The concept of choice is one of the components of the neurocognitive pool, which undergoes significant disturbances in the schizophrenic process. Concomitant diseases, such as chronic viral hepatitis, certainly affect the neurocognitive profile, exacerbating cognitive disorders, thereby affecting the social adaptation of this group of patients.

The purpose of the study is to study the features of problem-solving behavior in patients with paranoid schizophrenia with concomitant viral hepatitis.

Material and research methods. 64 patients diagnosed with F 20.0 "paranoid schizophrenia" were examined. The experimental-psychological part is represented by a test for problem-solving behavior - the "Tower of London", taking into account the execution time and the number of moves.

Research results. As a result of the study, it was possible to find out that the choice of strategy in solving the problem in the patients from the study group was significantly different from the comparison group. At the beginning of the experiment, 23 (48.9%) patients of the study group were skeptical and suspicious about the testing. During the experiment, in the study group, 34 (72%) patients had an increase in the time for constructing the tactics of task execution, on average it was 10-14 seconds, in the control group this indicator was 6-8 seconds. The average number of "moves" also differed from the control group and was 32-34 moves, while in the control group it was 27-29 moves.

Conclusions. Thus, in the course of the experiment, it was possible to find out that in the study group the main indicators of problem-solving behavior differed significantly from the comparison group, the time spent on building tactics for completing the task and the number of execution errors increased.

Молодежный инновационный вестник. 2023;12(S2):407-410
pages 407-410 views


Morozova A.L., Erkenova D.R.


The aim: To examine the effects of iron deficiency on mental processes.Relevance: Iron deficiency is the most common nutritional disorder worldwide and accounts for approximately half of anemia, making iron deficiency anemia a public health problem. The etiology of this disease varies and is explained by several risk factors that decrease iron intake and absorption or increase demand and loss, with multiple etiologies often coexisting in an individual patient. Although symptoms may be nonspecific, there is emerging evidence of the deleterious impact of iron deficiency anemia on clinical outcomes in a wide range of conditions, including psychiatric disorders and cognitive impairment. Increased awareness of the consequences and prevalence of iron deficiency anemia may facilitate earlier detection and treatment. Materials and methods: during the work we used data of scientific materials on the topic of iron deficiency anemia of leading domestic and foreign specialists in this field of psychiatry, as well as Russian- and English-language articles available in the databases: ELibrary.ru, Scopus, PubMed, Google Scholar, Europe PMC. The materials were searched using the keywords: GAD, iron deficiency anemia, iron metabolism. Inclusion criteria: full-text articles in Russian and English; original studies; clinical observations; monographs; guidelines. A total of 9 publications were found. Results: a literature review was conducted. Conclusions: iron plays a significant role in the functioning of neurotransmitter systems and basal ganglia; deficiency of this element is registered in a number of psychiatric and neurological disorders.

Молодежный инновационный вестник. 2023;12(S2):405-407
pages 405-407 views


Averina E.I., Podvigina V.S.


Relevance: The influence of smells on the sphere of feelings and sensations, their ability to serve as a stimulus for the emergence of certain emotions has not been sufficiently studied at the present time. However, olfactory neuroanatomy is closely related to the limbic system of the brain, which is considered the main area of emotions. That is why the use of olfactory stimulation as a method for assessing the emotional background is justified and relevant. Purpose: Development of a new, complex method for studying the emotional sphere using odors, rating scales and testing it on individuals with normal and pathologically altered emotional states - anxiety and depressive disorders. Methods and materials: Analysis of the results of a clinical study obtained using a set of odorants for olfactometry (rapid test 12), the scale of affective odor exposure (AIO), the scale of sensitivity to chemical odors (CSS-SHR), the odor questionnaire in everyday life (OELQ ), the Beck Depression and Anxiety Scale, the correlation of indicators with ten basic emotions according to K. Izard. Results: Sensitivity to specific common odors correlated with symptoms of depression or anxiety. Conclusion: The conducted research shows that the technique is adequate to the set goal and can be used to study both the emotional sphere of healthy subjects and the peculiarities of emotional states in pathology.

Молодежный инновационный вестник. 2023;12(S2):399-402
pages 399-402 views


Dobrynina M.S., Podvigina V.S.


Relevance. An overabundance of information, including those not related to training and professional activities, various social aspects and the rapid pace of life in a megalopolis are often stressful factors. Young people go through a difficult adaptation period, which includes an increase in the academic load, frequent stresses, for some students, including those associated with moving from their hometown, as well as a number of other factors affecting the level of anxiety and the nature of its manifestations.

Goal. Determining the level of anxiety and depression among first-year students of the medical and pediatric faculties of N. N. Burdenko VSMU, as well as students of the Mathematics Faculty of VSU is of particular interest in modern realities.

Materials and methods. In conducting this study, a standard set of 75 metaphorical spectral cards was used under the authorship of U. Khalkola, A. I. Kopytin, as well as clinical questionnaires of depressive states according to V.A. Zhmurov and manifestations of anxiety according to Taylor J., TMAS.

Results. It is known that frequently occurring anxiety, fears and psycho-emotional stress negatively affect not only students' academic performance, but also nervous and mental activity, leading to various pathological conditions. Using the technique of spectral metaphorical cards, it was possible to determine the main causes of anxiety and depression, as well as to analyze possible ways to level these conditions.

Conclusion. In this study, spectral metaphorical cards showed their effectiveness in determining the true causes of anxiety and depression, which helped the subjects express their thoughts, feelings, activate the emotional, behavioral and cognitive spheres of personality, as well as analyze possible ways to solve problems.

Молодежный инновационный вестник. 2023;12(S2):402-405
pages 402-405 views

Психология и поведенческая медицина


Abramova A.V.


Objective: to study emotional barriers in doctor-patient communication, where the patients were first-year students of the medical faculty of the N.N. Burdenko VSMU.

Methods: survey method, analysis method

The article discusses the issues of doctor-patient communication, specifies the principles that a doctor should be guided by in a dialogue with a patient. The concept of communication and a communicative act is proposed, two forms of communication are distinguished: verbal and nonverbal. The approaches to this issue of Russian authors are analyzed in detail. The results of an empirical study are proposed, where the emotional barriers of patients are identified, which are the respondents of the study: students of the medical faculty of the N.N. Burdenko VSMU.

Results. According to the received data on the diagnosis of communicative control (M. Schneider) respondents with low communicative control, who are characterized by spontaneity and openness in communicating with people in the form of excessive straightforwardness and obsession, almost invariably behavior despite the difference in situations, there are 10%. There are 60% of people with average communicative control who are free to communicate, sincerely relate to others, but are limited in their emotional state, measure their behavior with others. There are 30% of people with high communicative control, who take care of themselves and their emotions, who understand how to present themselves in the environment, but who experience certain difficulties during unforeseen interaction.

According to the method "Diagnostics of emotional barriers in interpersonal communication (V. V. Boyko)": there are 40% of people who experience emotional problems in daily communication. There are 20% of people whose emotions "for every day" become some kind of limiter in their relationships with others. There are 40% of people whose emotions do not allow them to create a relationship with others, most likely they are subject to some disorganizing reactions. And there were no people who were insincere in their answers, or who did not know themselves well from the outside, and people around him who were not hindered by emotions from communicating with others.

Conclusions. Thus, psychological or emotional barriers do not contribute to a fruitful communicative act, and understanding their origin and causes helps to reduce the negative impact. Therefore, consideration of a specific scheme for getting out of the psychological barrier situation is necessary. The main thing in this scheme is the observance of the rule of relationships, which forms all further contacts leading to harmony, taking into account the individual psychological characteristics of each individual.

Молодежный инновационный вестник. 2023;12(S2):411-414
pages 411-414 views


Alekseeva A.V., Gviniashvili S.G.


Relevance: currently, special attention is paid to the issue of personal growth of young professionals and their desire for self-realization, including professional.

Purpose: to raise the problem of personal growth of medical university students.

Materials and methods: survey of first and fifth year students of Astrakhan State Medical University. The questionnaires were evaluated according to the point system.

Results: the survey results were divided into three conditional groups. The assessment was carried out separately for first- and fifth-year students. The majority of first-year students fell into the second group - "undecided" (55%), the rest made up the third group - "striving for self-improvement" (45%).For the fifth year, the distribution is as follows. The majority of the questionnaires made up the third group (54%), 43% of respondents entered the second group, 3% of students got into the first group - "indifferent" to self–improvement.

Conclusions: in the process of studying at a medical university, in the presence of favorable conditions, students increase the level of self-development.

Молодежный инновационный вестник. 2023;12(S2):417-418
pages 417-418 views


Shulgina D.A.


The relevance of the research topic is due to the modern requirements imposed on a university student, to the ways to achieve goals and results in the educational process, and in the future to successfully build a career. The article analyzes separate concepts such as "laziness" and "procrastination". The term "laziness" is considered as a form of procrastination. Their interrelation with each other and the specific features of the concepts being studied. Erroneous opinions related to phenomena in the course of work are reviewed and eliminated. All individual characteristics and their influence on the University student in the educational process are studied: self-esteem, temperament, psychological prerequisites of laziness. Attention is focused on the causes and factors of these phenomena. With the help of an empirical study conducted on first-year respondents of the Pediatric Faculty of Voronezh State Medical University, the results of which allow us to trace and eliminate the relationship of the problem. Also, the data of the survey carried out note the high effectiveness of the methods: the Eysenck questionnaire for the study of temperament and the S.A. Budassi method for determining self-esteem, which allows for a more accurate analysis. Systematic exercises are proposed to combat the described phenomenon in order to increase motivation and efficiency.

Молодежный инновационный вестник. 2023;12(S2):426-428
pages 426-428 views


Meroyan Z.H.


Relevance: Stress is a common work-related problem worldwide. Most people spend the bulk of their adult lives working in an environment in which they face a wide variety of physical and psychological challenges leading to varying levels of stress [1]. Work has a significant impact on the health of workers in many areas of activity, especially those that require increased concentration of attention, prolonged stress [2]. In busy workplaces, it can be difficult for people to adjust to work, colleagues, and the organization. This can increase the number of factors that create stress in the workplace and increase the perception of these factors by employees. The scientific literature contains studies that consider the causes, consequences and ways to overcome work stress (Usca, 2013; Smith et al., 2019; Yang et al., 2019), but in our country this issue requires attention and study [3, four]. The activities of a number of state organizations are responsible for the life and health of the population. One of such organizations is JSC Russian Railways. The well-established network of transportation of passengers of this organization throughout the country should function efficiently at all stages and sectors of activity, from engineering departments to crane operators, machinists and operators. Excessive fatigue against the background of chronic stress affects the quality of work of Russian Railways employees, which in turn can lead to negative consequences.

Purpose: To identify factors that negatively affect the stress resistance and mental health of railway workers according to scientific publications of domestic and foreign authors, as well as according to anonymous survey data.

Methods: Epidemiological analysis of the incidence of railway transport workers in the city of Voronezh and the Voronezh region according to statistical accounting and reporting forms and an anonymous survey of workers who were in the hospital of the CHUZ CB "RZD-Medicine" in Voronezh. The questionnaire consisted of several parts, one of which assessed their stress resistance. Statistical data processing was carried out using the Exsel software package.

Result: An anonymous survey involved 100 respondents who at the time of the survey were in various departments of the hospital of the CHUZ "KB" RZD-Medicine "Voronezh", Stationary unit No. 1 (at Voronezh-I station): gastroenterological, cardiological, neurological, pulmonological , endocrinological; 16 different divisions of the railway, of which men accounted for 69.8%, women - 30.2%. The average age of employees was 47 years. Four psycho-emotional factors were identified that affect stress resistance: going to work during an illness, painful experience of troubles, lack of time for rest, lack of time for doing what you love.

Conclusion: The dynamics of the incidence of employees of the PHI "Russian Railways Medicine" for the period from 2018 to 2021. characterized by distinct periods of rise and fall in indicators: in 2021. -594.1 and in 2019. - 517.6 per 1000 employees, respectively. The survey showed that such factors as “Coming to work when sick”, “Painful experience of trouble”, “Lack of time for rest”, “Lack of time for doing what you love” can adversely affect the mental health of iron workers, which in turn queue negatively affects their stress resistance and the quality of work performed.

Молодежный инновационный вестник. 2023;12(S2):423-425
pages 423-425 views


Kryzhka V.V., Kondacova A.O., Kolomatskaya V.V.


In recent years, a lot of research has been concentrated on the study of burnout syndrome. Emotional burnout syndrome is a symptomatic complex of psycho-emotional, motivational-attitude and holistic disorders that occur with prolonged exposure to various adverse professional factors [1].

The main signs of burnout are: severe exhaustion, a feeling of cynicism and detachment from work, a feeling of inefficiency and a reduction in professional achievements [2].

With the impact of severe, debilitating factors, a person can meet not only at work, but also while studying at the university, especially since at the moment a large number of students combine study with work.

At the moment, additional factors that increase the risk of burnout and depression are the coronavirus infection of 2019, quarantine restrictions, as well as socio-economic restrictions.

Another problem is the relationship between burnout syndrome and depression. Recent studies indicate a close relationship between these two phenomena: both emotional burnout can lead to the further development of depression, and depression can be a predictor of emotional burnout [3,4]. In this regard, burnout syndrome as a factor in the development of depressive disorder is of particular socioeconomic importance, since depression occupies one of the leading places in the world among all medical causes of disability and mortality among young people [5].

Молодежный инновационный вестник. 2023;12(S2):420-423
pages 420-423 views


Akyneeva T.D.


Relevance: The problem of professional stress is acute in modern society. Railway transport workers experience mental stress on a daily basis not only against the background of emotional instability, but also in connection with external stimuli that have a direct impact on human health, causing various general pathological syndromes.
Purpose: To conduct a survey among railway transport workers who are being treated at a Road clinical hospital in the city of Voronezh for the presence of neuropsychiatric stress using a questionnaire in the Google form format.
Methods: Descriptive and evaluative analysis of the development of neuropsychic stress of railway transport workers in the period from June to December 2022..
Results: An anonymous survey was conducted to assess the neuropsychiatric stress among railway transport workers in the Voronezh Region. The structure of the neuropsychiatric stress questionnaire (T.A.Nemchin) included 30 questions, which were a list of signs of neuropsychiatric stress, divided into three degrees of severity: mild, moderate and excessive neuropsychiatric stress. 100 respondents aged 25 to 70 years took part in the questionnaire, men accounted for 62%, women 38%.
By profession, among the respondents there were: dispatcher, machinist, assistant machinist, engineer, inspector-repairman, electrician, accountant, deputy head of department, head of sector, electrician, announcer, road foreman, adjuster, electrician, crane operator, depot attendant, boiler room operator, track fitter, operator, relocation attendant, warehouse manager, cargo and baggage receiver, power engineer, work distributor and locksmith.
The interviewees were in five departments of the hospital: gastroenterological, neurological, endocrinological, pulmonological and cardiological.
As a result of the analysis, it was found that 93% of workers with mild neuropsychiatric stress accounted for, 3.5% accounted for moderate neuropsychiatric stress, and 3.5% accounted for patients with excessive neuropsychiatric stress.
Conclusion: The survey revealed the presence of moderate and excessive neuropsychiatric stress among railway transport workers among men aged 25-40 years and 51-70 years, mainly having such a profession as an engineer and a moving attendant.
A high proportion of the development of neuropsychiatric stress is observed in patients undergoing inpatient treatment in the hospital in the departments of neurology and pulmonology.

Молодежный инновационный вестник. 2023;12(S2):414-416
pages 414-416 views


Antonian R.T.


Relevance. The professional orientation of any person significantly determines his future, the ability to self-actualize, get satisfaction from work and the value of a person of working age for the state. Goal. This determines the purpose of the work – to identify the features of the professional orientation of first-year students of the N.N. Burdenko VSMU. Materials and methods. The study involved first-year students of the pediatric, preventive medicine, dental and Pharmaceutical faculties of the N.N. Burdenko VSMU. The identification of professional orientation was carried out on the basis of a differential diagnostic questionnaire. Results. The results obtained indicate that the professional orientation of first-year students is carried out in accordance with the interests and inclinations of the respondents.This is a significant conclusion, indicating that every employee of the organization should be in his place and do the work for which he has the maximum predisposition. Conclusion. However, the interviewees do not see their professional orientation related to calculations, measurements, presentation and processing of the received data. This contradicts the scientific side of any activity and is a disadvantage of modern school education in Russia.

Молодежный инновационный вестник. 2023;12(S2):418-420
pages 418-420 views

Сестринское дело


Likhachova V.M.


The relevance of this topic is due to the need to highlight the work of the school of first aid (PP), because this is one of the forms of preventive work of medical staff, which consists in training participants in the main aspects of providing assistance directly at the scene of events. The purpose of this school is to raise public awareness about the basics of first aid, its scope, responsibility and effectiveness criteria.
The main directions of the school of first aid:
1. Formation of students' strong skills and conscious knowledge in first aid
2. Formation of the correct algorithm of actions in providing first aid to victims
3. Formation of students' correct attitude to their health
4. Increasing the interest of the population in the field of first aid training
5. Formation of knowledge about the signs of pathological conditions that require urgent measures.
The role of a nurse in the organization and work of the school of the first pomorsch:
1. Informing the population on the most pressing issues of first aid
2. Development and consolidation of skills performed during first aid
3. Clarification of rights and obligations in the provision of first aid
As a rule, in the event of an accident, eyewitnesses of the incident can provide assistance-ordinary people who have the right to provide it. Basically, such people have minimal training and knowledge in first aid. Nevertheless, eyewitnesses of the incident can perform simple actions and eliminate the immediate danger to the victim.
The purpose of the work is to determine the main activities of a nurse in the first aid school.
Materials and methods. In the course of the study, a questionnaire was conducted during 2022-2023 in the social network VKONTAKTE. 52 people participated in the survey.
The results of this survey show satisfactory results of the analysis of people's basic knowledge about in the field of providing PP. The survey also showed a lack of knowledge in some areas.
Conclusion The purpose of preventive work of nurses is to provide as much practical and theoretical knowledge as possible in the field of first aid, demonstration and development of basic skills, clarification of legal aspects, therefore their role in the school of "First Aid" is very great. Nurses make a great contribution to the development and functioning of such schools, increasing the medical literacy of the population. Basic knowledge about first aid, not only can be useful to the listeners themselves in everyday life (for example, first aid for burns), but also can save the lives of other people

Молодежный инновационный вестник. 2023;12(S2):434-437
pages 434-437 views


Ishutin R.D.


Relevance. One of the most common disorders of the endocrine system of the Russian population is diffuse toxic goiter. Since the thyroid gland performs many vital functions, if these functions are violated, a person begins to suffer from a wide range of developing pathological conditions, up to and including death.
Purpose: to analyze students' knowledge about the diagnosis of hyperthyroidism, the features of care for this pathology, and preventive measures.
Materials and methods. In the course of the study, a survey was carried out, the analysis of the information received and literary sources was carried out, then the statistical processing of the results was performed.
Results. Questioning of future medical workers showed their awareness of the issues of diagnosis and prevention of thyrotoxicosis, the features of care for this pathology. Early detection of the disease is very important for the preservation of vital body functions. After all, thyroid hormones affect all systems of human organs, with a lack or excess of them, an imbalance of all processes is observed.
Conclusion. Currently, there is a real danger of the progression of thyroid diseases in endemic areas of residence, due to nutrition and lifestyle, neglect of rational nutrition measures, and the presence of unhealthy food preferences. Future doctors showed good awareness of issues related to the characteristics of the clinical manifestations of thyrotoxicosis, its prevention and organization of care for this pathology. A sufficient level of knowledge about the prevention of thyrotoxicosis, alertness to this disease gives reason to think that future health workers will be able to effectively organize and conduct health education activities and timely detect pathology before complications develop.

Молодежный инновационный вестник. 2023;12(S2):432-434
pages 432-434 views


Nikulina D.S.


Relevance. Statistics show that myocardial infarction (MI) is most common in people over 50 years of age. This group accounts for more than 40% of cases.Myocardial infarction is a serious and potentially fatal disease caused by necrosis of the heart muscle. The most common cause of necrosis is spasm of the coronary arteries, deterioration of the trophism of the heart, called coronary insufficiency. Myocardial infarction is an indication for hospitalization, and with proper medical care, the patient has every chance of recovery. However, the important prerequisites are timely qualified care, strict adherence to the treatment plan and adequate nursing care.The role of a nurse in caring for a patient with a myocardial infarction is difficult to overestimate, since she fulfills all the doctor's prescriptions. With this pathology, the patient observes strict bed rest, so the average medical staff provides the patient with satisfaction of vital needs.The purpose of the work is to study the main activities of a nurse in myocardial infarction.Materials and methods. The study was conducted by questionnaire, in 2022 on the basis of medical organizations in Voronezh, Voronezh
State Medical University. N.N. Burdenko, as well as through social networks. 50 people took part in the survey.Results. The results of the survey showed that the awareness of the population about myocardial infarction, the role of nursing care is good, but awareness about first aid for it, the peculiarities of diet, physical activity is insufficient.

Молодежный инновационный вестник. 2023;12(S2):437-439
pages 437-439 views


Askerova A.G.


The need for the formation of «soft skills» is dictated by the requirements of modern professional training of medical specialists. Objective: to determine the formation of «soft skills» among medical college students studying in the specialty «Nursing». Materials and methods: The «4K» competence model has been studied. The content of the Federal State Educational Standard SPO in the specialty «Nursing» is analyzed. A survey of medical college students in the specialty «Nursing» (N=1219) was conducted. The self-assessment of the skills characterizing the formation of the relevant competence was carried out on a five-point scale. Results. 81.1% have an idea of the concept of «soft skills». 58.6% believe that the formation of «soft skills» skills begins during school. Practical methods are the most effective in the formation of «soft skills» (72.3%). It is necessary to use group teaching methods (82.5%). There is no reliability of the differences between the average ranks when determining the importance of «soft skills». The «soft skills» of future mid-level specialists are well formed. Conclusion. Students understand the importance of developing «soft skills» for successful professional activity. The educational organization needs to ensure the use of methods of effective formation and improvement of «soft skills».

Молодежный инновационный вестник. 2023;12(S2):429-432
pages 429-432 views


Sukhareva D.S.


Relevance. Human papillomavirus (HPV) is one of the most common viruses on the planet. At the moment, there are more than 190 different types. Papillomaviruses of high oncogenic risk are isolated from a huge number of HPV species. 49% of uterine body cancer per 100,000 female population. This type of cancer ranks 3rd among all oncological diseases in women. Timely prevention of the virus will help reduce mortality.

Goal. To study the human papillomavirus, to carry out preventive measures among the population aged 16 to 25 years, to examine patients with HPV in a surgical and gynecological hospital.

Materials and methods. During the research work, statistical data on HPV in the Voronezh region and the incidence of this virus in Russia were used. A survey was conducted among girls aged 16 to 25, which helped to identify what needs to be prepared for a preventive conversation. A visual examination of patients of the outpatient surgery center treated with papillomas and the gynecological department at BSMP No. 10 was carried out.

Result. My research has shown that girls aged 16 to 25 years — 61.5% of those who passed the survey, know their HPV status and undergo annual gynecological examinations. 95% of respondents were not vaccinated against HPV for various reasons. Most of the respondents explain this by fear of vaccination and fear of its consequences, as well as tell that they did not know about the existence of an HPV vaccine. 5% of the respondents were vaccinated.
Examining papillomas, it can be concluded that not all neoplasms of a benign nature need to be surgically removed. Only those papillomas that have changed color, shape, size over time, do not have clear boundaries, etc. are subject to removal. indications.

Conclusion. Work to educate the population about HPV, its transmission methods, diagnosis, treatment and prevention is necessary. This should become an integral part of the work of doctors and nurses, especially in the field of gynecology, urology, surgery, oncology, pediatrics. Most of the surveyed population showed interest in the research topic. It is necessary that as many girls as possible are vaccinated against the human papillomavirus. This will reduce mortality from cancer. It is also important to explain to the population at the appearance of which neoplasms on the skin it is necessary to immediately contact a surgeon.

Молодежный инновационный вестник. 2023;12(S2):440-442
pages 440-442 views



Yericyan O.A.


Relevance. Finishing treatment during dental restoration is one of the important stages in achieving an aesthetic and functional result that satisfies both the doctor and the patient. The aim of the work is to find the most optimal protocol for finishing the restoration, which will meet the highly aesthetic requirements. Material and methods. Modeling of restorations with composite material was carried out on the phantoms, five finishing protocols were carried out on the restorations. A photoprotocol of works was carried out at each stage for the purpose of further evaluation. The results of the study. Each protocol is evaluated in points, according to the results of the score evaluation, a protocol was identified that meets all the requirements of modern finishing: it gave an ideal dry shine, smoothness of the surface and color stability in the optimal time spent. Conclusion. The article is devoted to a close analysis of modern protocols for finishing and polishing seals. According to the results of the score assessment, the optimal protocol for finishing and polishing seals was identified.

Молодежный инновационный вестник. 2023;12(S2):455-458
pages 455-458 views


Phatov S.A., Matkarimov J.R.


Relevance. At the present stage of the development of dentistry, special attention is paid to oral hygiene, since neglect of the latter leads to various diseases of the oral cavity. One of the main hygiene products is toothpaste.
Objectives of the work. To investigate the composition of toothpastes, as well as to determine the range of their use in everyday life.
Materials and methods. Work was done on the study of scientific literature, as well as the composition of the most popular toothpastes was investigated. In addition, the ranking of the latter was carried out to reflect the degree of their effectiveness.
Results. Comparative characteristics of toothpastes showed the following: for the prevention of caries, pastes containing fluoride, calcium, magnesium, phosphorus, as well as various indicators for staining untreated plaque on teeth are the most effective; for the treatment of gingivitis, periodontitis, it is most advisable to use toothpastes based on plant extracts, salts, enzymes or biological additives; enzyme-based toothpastes are mainly used to improve the aesthetics of the dentition, in particular for whitening.
Conclusion. Based on the conducted research, it can be concluded that there is no universal solution to all problems of the oral cavity in the form of a specific toothpaste at the moment. To solve the problems of a particular patient, an individual algorithm for solving them is required.

Молодежный инновационный вестник. 2023;12(S2):465-467
pages 465-467 views


Nazarova A.D.


One of the criteria for successful dental treatment is the painlessness of the procedure and the psychophysiological comfort of patients.
The purpose of this work is to study the clinical and pharmacological properties of modern carpular anesthetics of the amide series.
Sources and methods. The work was carried out on the basis of the analysis of literature sources: manuals, monographs and statistical data of Russian and foreign specialists in the field of anesthesiology, chemistry and stomatology.
Results and their discussion. In the course of the work, the research was considered dedicated to the study of the effectiveness and biological safety of anesthetic agents of the amide group.
Conclusions. Analysis of domestic and foreign studies statistical data, as well as literature sources have shown that the most optimal and effective carpular anesthetic of the amide series in dental interventions is articaine, which is due to the high rate of onset and strength of anesthesia, sufficient duration, low toxicity and allergenic of this anesthetic.

Молодежный инновационный вестник. 2023;12(S2):462-463
pages 462-463 views


Lisitsyn M.A.


Relevance. Preliminary monitoring of the data allowed us to conclude that among all diseases, a fairly high percentage belongs to diseases of a dental nature, which leads to a decrease in a person's ability to work, additional costs for the treatment of patients and their prevention.
Goal. The aim of the study is to increase the effectiveness of the use of light physical factors in the treatment of pathological conditions of the oral mucosa, which are detected during removable prosthetics, as well as to study the effectiveness of orthopedic treatment using various light physical factors in combination with medications.
Methods. To conduct the study, it was necessary to divide patients into two groups for the appointment of various physical devices.
Results. In patients of groups 1 and 2, after applying partial and fully removable dentures, an acute inflammatory reaction of the oral mucosa was detected in response to increased pressure transmitted through the bases of the prostheses.
Conclusion. When using complex treatment of the mucous membrane in group 1, hyperemia disappeared on the third day, and in group 2 patients - on the second day. The swelling went away the next day.

Молодежный инновационный вестник. 2023;12(S2):461-462
pages 461-462 views


Babkin G.R.


The number of dental patients with various oral diseases developing against the background of COVID-19 is rapidly increasing, among which are multiple dental caries, periodontal tissue lesions, as well as a variety of diseases of the dental pulp. A history of diabetes mellitus is also known to have a significant impact on the course of oral lesions and diseases. A study was conducted to determine the need for repeated endodontic treatment in patients who had previously undergone COVID-19 and had a history of diabetes mellitus due to complications in the periodontal complex. Radiological follow-up 1 year after the primary endodontic treatment revealed that such patients required repeated endodontic treatment much more frequently (76.2% of cases) compared to patients without confirmed somatic pathology (11.4% of cases). One of the reasons causing complications in the treatment of complicated forms of dental caries can be the lack of treatment complexes capable of completely eliminating the inflammatory process in the root canals. And the history of diabetes mellitus in combination with COVID-19 promotes more rapid spread of the infectious process to periodontal tissues with subsequent pathological changes in them and destruction.

Relevance. Diabetes mellitus is a common pathology of the endocrine system, also the number of patients with coronavirus infection is increasing every year. History of diabetes mellitus in combination with COVID-19 also contributes to more rapid spread of the infectious process to periodontal tissues with subsequent pathological changes in them.

Objective: to determine the treatment rate of patients with a history of coronavirus infection and diabetes mellitus for chronic pulpitis
Materials and Methods. Analysis of data obtained by the study of archived medical records of dental patients, where COVID-19 was indicated in the column "previous diseases" was carried out. A total of 56 dental records of such patients were selected and analyzed. Among them there were distinguished 2 groups of patients: basic (21 patients with diabetes mellitus) and control (35 patients without confirmed somatic pathology).

Results. According to data of X-ray investigation among the patients with diabetes mellitus in the anamnesis (the 1st group) 16 patients (76,2%) required repeated endodontic treatment a year later. Among the patients without confirmed somatic pathology (the 2nd group) according to X-ray investigation 4 patients were found to have periapical changes and require re-treatment of the root canals, that is 11,4%.

Conclusions. The success of treatment of chronic pulpitis after coronavirus infection and in patients with diabetes mellitus depends on the joint management of the patient with an endocrinologist.

Молодежный инновационный вестник. 2023;12(S2):445-447
pages 445-447 views


Gabidullina V.R.


Relevance. The issue of choosing antibiotics in the practice of dental implantation remains debatable. There are a large number of studies, the conclusions of which often contradict each other, which indicates the high relevance of this issue. The aim of this work was to evaluate the subjective and objective clinical manifestations of the early postoperative period in patients after dental implantation taking a prolonged regimen of amoxicillin/clavulanate. Materials and Methods. The study included 20 patients who were indicated for delayed dental implantation in uncomplicated anatomical conditions. As a preoperative preparation, the antibiotic amoxicillin 875 mg + clavulanic acid 125 mg was used 30 minutes before the operation. Further, after the operation, a regimen of amoxicillin/clavulanate 500+125 mg 1 tablet 2 times a day for 7 days was prescribed. The installation of dental implants was carried out according to a standard protocol. Patients were examined on the 1st, 3rd, 7th days after the operation with the registration of such indicators as pain, the severity of hyperemia, edema, exudative phenomena, suture divergence. Pain was assessed using a visual analog scale, where 0 means no pain and 10 means unbearably severe pain. The patient noted on a segment from 0 to 10 his sensation of pain. Hyperemia, edema, discharge, and suture divergence were assessed on a scale of 0 to 3 points. All results were collected in a single table and analyzed. The program "Statistics" was used to compare data within the group. Comparison of dependent data within a group of patients was carried out by using the nonparametric Wilcoxon Signed Ranks Test to compare dependent groups. Results. The average value of pain for patients on the 1st day was 1.6 points, on the 3rd day - 0.53 points, on the 7th day - 0.13 points. The severity of hyperemia on the 1st day was 0.93 points, on the 3rd day - 0.33 points, on the 7th day - 0.2 points. The results for edema were as follows: on the 1st day 0.93 points, on the 3rd day - 0.53 points, on the 7th day - 0 points. Discharge on the 1st and 3rd day was 0 points, on the 7th day - 0.15 points. The divergence of the seams on all days of observation was 0 points. Adverse events from the gastrointestinal tract were noted in 3 out of 20 patients. Conclusion. The appointment of a prolonged antibiotic regimen for patients after dental implantation, with a high degree of probability, has a positive effect on the clinical course of the early postoperative period, while adverse effects from the gastrointestinal tract are possible.

Молодежный инновационный вестник. 2023;12(S2):450-453
pages 450-453 views


Tsybulkin A.O., Terekhova Y.S.



Odontopreparation is one of the indispensable stages of treatment in the selection of fixed prostheses, as a result of which the doctor has to remove a large amount of dental hard tissue, thereby overheating the surrounding tissue due to the abundant heat released by the cutting instruments, which may subsequently lead to undesirable complications, such as inadequate dentin dehydration.


Purpose of the report.

To tell our colleagues about how it is possible to avoid the above complications, to reveal all features of a structure of firm tissues of a tooth.


Materials and methods.

We will present types, methods and principles of traditional preparation.

We will tell about innovative technologies in odontopreparation and modern systems of cooling.



As a result of our report, the current generation of doctors will know all the possible problems of this manipulation, and the most important thing - how and how to circumvent them.



After reading our article, you'll learn a great deal about how to perform a preparation with minimal risk of complications.

Молодежный инновационный вестник. 2023;12(S2):470-472
pages 470-472 views


Furkatov S.F., Khazratov A.I.


It is recognized that insignificancy length of existence a individual according to losing teeth. subsequently the deprivation of characteristic teeth, the manductioning of chop chop breaks apart down, the faithfulness of articulation worsens, the arrival of a individual changes. This is each the shadow of a doubt reproduced on his psychosomatic sovereign state mood, behavior, and on the ‚ lan vital and collective make fast of a person. thither were 32 (11 men and 21 women) full of years general public (61-71 second childhood old) with imperforate and (or) discriminative deprivation of sets in the more elevated and mark down jaws, who had not antecedently euphemistic pre-owned dismissible paint dentures. dismissible paint discriminative and (or) integral dismissible paint prostheses were make-believe for each patients on the authority of the customarily conventional technology.

Молодежный инновационный вестник. 2023;12(S2):467-470
pages 467-470 views


Kussainova Z.D., Bulegenov T.A., ABRALINA S.S., ABILTAEV A.M., Nasymbekov M.R., Suleimenova D.M.


Relevance. Infective endocarditis (IE) is a rare but devastating condition in which the innermost lining of the heart becomes infected. This may include more than one valve, which can lead to severe valvular failure and heart failure. It can also progress to abscess formation, septic embolism, stroke, and organ ischemia [1].
Knowledge, current practice, and inconsistency in pre-procedure antibiotic prophylaxis against infective endocarditis for patients with various cardiac lesions is a prerequisite for the development of infective endocarditis.

Aim. Conduct a literature review of scientific studies studying the incidence of infective endocarditis in order to substantiate the relationship between infective endocarditis and odontogenic infection.
Materials and methods. A systematic review was conducted in the PubMed electronic database with a depth of 5 years from 2018 to 2022.

Results. The aim of the study was to investigate the relationship between infective endocarditis and odontogenic infection. As a result of a systematic review, most studies on the etiology of infective endocarditis indicate Staphylococcus aureus as the main causative agent of IE. In second place in terms of frequency of the pathogen is the group Streptococcus viridans, as a result of which a connection between infective endocarditis and odontogenic infection is assumed, since the incidence of this group of streptococci is characteristic of odontogenic infection.

Findings. The data obtained during the study related to the research topics indicate that a more in-depth and evidence-based study of the type of RCT is needed due to the incompleteness of the available data. Therefore, it is impossible to completely refute the relationship between infective endocarditis and odontogenic infection according to the available data, as well as its absolute confirmation.

Молодежный инновационный вестник. 2023;12(S2):458-461
pages 458-461 views


Gerasimova K.E.


Relevance. Diagnostics of the oral cavity in patients undergoing orthodontic treatment is relevant at all stages of treatment. Early detection of unsatisfactory oral hygiene in children and adolescents with a bracket system helps to prevent the development of undesirable consequences.
Purpose. To determine the awareness of patients and parents about the methods and means of oral hygiene, as well as the amount of carbohydrate intake.
Materials and methods. Questionnaire methods, clinical and statistical methods were used to determine the awareness of patients and their parents.
Results. In the course of the work, it was revealed that there is a relationship between the attitude of patients to oral hygiene and the awareness of parents in this matter.
Conclusion. The questionnaire contributes to the early detection of parents' incompetence in matters of the quality of oral hygiene of their child, the amount of food consumed, as well as the means and methods of individual hygiene.

Молодежный инновационный вестник. 2023;12(S2):453-455
pages 453-455 views


Antsupova I.D.


Relevance. Crowding of teeth is one of the most common deformities in orthodontic patients. Ankyloglossia (agkilos-curved; glossae-tongue) is a developmental anomaly characterized by the presence of a connective tissue fold (frenulum) formed by the upper aponeurosis of M. Genioglossus, interwoven into the ventral part of the tongue between its tip and the middle third. The prevalence of this anomaly is 1-10% (4-16% in newborns).
Goals. To determine the severity of crowding in patients with ankyloglossia.
Materials and methods. The analysis of the study included 32 patients aged 12-30 years. 15 male and 17 female, planning their treatment in the clinic "City of Smiles" and BUZ IN DKSP No. 2 in the period from January to December 2022.
To determine the severity of crowding of teeth in the lower jaw, the Little method was used.
Clinical determination of the frenulum of the tongue is carried out by the Kotlow method (1999): 4 degrees of freedom of the tongue (12-16 mm - mild ankyloglossia, less than 3 mm - severe ankyloglossia).
Results. During the measurements, it was found that 12.5% of patients have a space deficit of up to 3mm (minority crowding), 35.5% of patients have a space deficit of 3 to 5 mm (moderate crowding), and 52% of patients have a space deficit of over 6 mm (pronounced crowding). In a clinical examination of patients according to the Kotlow classification, it was revealed that 72% of patients have a history of a short frenulum of the tongue (severe ankyloglossia).
Conclusion. In the modern world, such pathology as angiloglossia is becoming more common.
According to the Sepet E study, mild and moderate types of ankyloglossia are not associated with crowding of the mandibular incisors and the type of bite, and the pronounced and severe degree has a direct impact.

Молодежный инновационный вестник. 2023;12(S2):444-445
pages 444-445 views


Utrobina I.I., Titova A.A.


The article contains data on the features of therapy of patients with mesial occlusion in combination with hypodentia of the teeth of the upper and lower jaw.
Relevance: mesial occlusion is currently widespread among the population. It leads to functional and aesthetic disorders that psychologically affect the body as a whole. As a result, the need to develop modern and most effective methods of eliminating this anomaly increases.
Objective: to find new ways to treat mesial occlusion.
Materials and methods: case histories of 21 patients; clinical, biometric, statistical, retrospective, etc. research methods.
Results: all the studied patients had grade 1 mesial occlusion, as well as anomalies in the sagittal and transversal planes, palatineoclusion, vestibulooclusion, reverse incisor overlap and rectus occlusion.
Conclusion: to eliminate the pathology in question, it is first necessary to create a place in the dental arch. It is also necessary not to forget about age and individual characteristics, about the stability of permanent and temporary teeth [1].

Молодежный инновационный вестник. 2023;12(S2):463-465
pages 463-465 views


Allekrad A.H.


Relevance: At this time, the number of people suffering from various defects of the dental system is increasing, one of the reasons is the loss of teeth.
The purpose of the work:
To identify the most important factors influencing the adaptation to full removable prostheses to increase the effectiveness in orthopedic treatment.
Materials and methods of research:
A very large number of synthetic elastomers used for the manufacture of two-layer bases of the prosthesis are now known.
The following research methods were used in this work:
• Sociological survey method
• Clinical examination method.
Research results:
We conducted a survey of three groups and found out which group has the best adaptation to full removable prostheses.
So, the use of a two-layer basis for prosthetics reduces the adaptation time of patients by minimizing the traumatism of the prosthesis tissues and the uniformity of pressure distribution on the prosthesis.

Молодежный инновационный вестник. 2023;12(S2):443-444
pages 443-444 views


Bogacheva K.K., Zhukova A.S.


Relevance. Doctors around the world are seeing an increase in the incidence of bronchial asthma (BA), the main treatment for which is the phased introduction of various inhaled hormonal substances (IGCS).

Currently, hypersensitivity under consideration is one of the main diseases of the oral mucosa (OM). The topic of bronchial asthma is considered relevant for all countries of the world, and in some of them this disease can be distributed up to 10% of the total types of diseases.

Target. Examine the state of the oral cavity of patients with the disease - bronchial asthma. To determine the relationship between prolonged use of inhaled hormonal substances and damage to the sensitivity of the oral mucosa.

Materials and methods. In this work, the results of patients with a history of bronchial asthma were used and studied in terms of varying degrees of severity (from the age of majority to 69 years). Divided into subgroups of patients who used inhaled hormones depending on the duration of use.

Research results. In all the subgroups examined, there were no particular differences in the results of pH before treatment, but the indicator of lysozyme activity differed significantly in contrast to the time of use of inhaled hormonal substances.

Conclusion. A comparative analysis of the results shows that the main cause of paresthesia of the oral mucosa in patients is the negative impact of inhaled hormonal drugs used in the treatment of bronchial asthma.

Молодежный инновационный вестник. 2023;12(S2):448-449
pages 448-449 views

Управление в здравоохранении


Vanina A.A., Orechova M.V., Karapetyan A.S.


Relevance. The last decade has seen an active rise in the age of first pregnancy and childbirth. Women of late reproductive age, in addition to increased risks for themselves during such a pregnancy, have increased risks for the unborn child. There are disagreements in society on this topic, so it is important to form the correct perception of this problem among future specialists. The purpose of the study is to determine the degree of awareness of late pregnancy and its risks among medical students. Materials and methods. To carry out the study, a survey of 4-6-year students who completed the obstetrics course was conducted. Statistical analysis of the indicators of awareness in determining the time intervals of such pregnancy, its risks, management tactics, etc. Study results. A satisfactory level of awareness in late pregnancy and childbirth was identified, but there are a number of omissions in specialized training in a number of issues. Many students underestimate the risks of such pregnancy and are not wary of reproductive health issues. Conclusion. It is necessary to increase the medical knowledge of students in these issues in order to form the right attitudes to preserve collective health. And for women she conducts educational measures to prevent the risks of such a pregnancy.


Молодежный инновационный вестник. 2023;12(S2):483-485
pages 483-485 views


Merzlikina L.E.


In the modern world, where the "shortage" of dental clinics is more than 100%, it is difficult to talk about the problems of the quality and availability of dental materials. In such a rapidly developing industry, by definition, there should be a high level of productivity and, accordingly, competition. However, in practical applications, there are certain difficulties associated with various reasons. In the context of high competition and the great popularity of materials brought from abroad, many domestic manufacturers faded into the background in the selection of funds used in medical practice, in particular in dentistry. Drugs for choosing a dentist are the key to the success of his activities. There are many stereotypes about the quality of domestic production. Are they all true? Do doctors know how this or that material differs? What are their preferences and what is worth paying attention to? The answers to these questions determine the relevance of this article. The purpose of the work is: to assess the possibility of replacing imported materials; identifying the main issues impeding this process. In the process of this work, the following materials and methods were used: questionnaires among patients and practicing dentists in Voronezh; analysis of literature data, study of qualitative characteristics of sealing materials. As a result of a comprehensive analysis of the studied literature and the study conducted, it was possible to find out the reasons that restrain the development and introduction of domestic materials in the dental industry. The import substitution process is a long process that requires not only a special approach to the solution, but also time for its implementation.

Молодежный инновационный вестник. 2023;12(S2):512-515
pages 512-515 views


Ulyanov I.A., Ulyanova A.V.


Relevance. The prevalence of smoking in general and vaping in particular remains at a consistently high level, the assessment of which will serve as the presented work.The aim of the study is to determine the frequency, type of smoking, as well as the attitude of smokers themselves to their addiction.The material was obtained by questioning 291 students from different universities of Voronezh and subsequent analysis of the submitted answers using the StatTech v program. 1.2.0 using the "Fisher exact criterion" and chi-square Pearson at p < 0.05.As a result of the survey, we found out that 25% of respondents smoke daily, 7% - several times a week, and 6.2% smoke once a month. As for the popularity of various nicotine delivery systems among regular (daily and several times a week) smokers, 59% use vapes, 21% use cigarettes, 14% use electronic tobacco heating systems, and 6% use nicotine-free devices. The most significant disadvantage of vapes, cigarettes and electronic tobacco heating systems for their owners is the high cost of these devices; the reason for starting smoking for most was stress, interest in second place. About 60% of respondents in groups using vapes and cigarettes do not plan to quit smoking, and in a small group of electronic tobacco heating systems, the number of those who do not plan to quit was only 28%, and 21% noted that with the help of these devices they managed to give up cigarettes.Thus, it can be concluded that in the student environment of Voronezh, the number of daily smokers is 25% and vaping is the most widespread, and the majority of respondents do not intend to give up smoking. This situation requires new approaches to the fight against smoking, which will be studied and used by the team of authors in the future.

Молодежный инновационный вестник. 2023;12(S2):533-535
pages 533-535 views


Sukhanova E.S., Kozhevnikov V.V., Chernokoz A.A., Markosyan Z.S.


According to a recent study of the Russian Periodontological Association conducted in 9 regions of the country, 65% of individuals with some form of periodontal pathology are nonadherent to treatment [1]. Currently, the issue of reducing the risk of adverse outcomes is one of the most important in the field of medicine. The relevance also lies in the ability to observe the effectiveness of the program almost immediately after its implementation, which shows us the importance of improving the work in this area of medicine
The aim of the study is to reduce the risk of adverse outcomes through improved health screening
Materials and methods of the research are the objects of research (the patients of the dental profile and medical records) and the studied phenomena (the primary diseases of the dental profile, 1st and 2nd line complications and outcomes).
The results of the given program are: increase of the general level of dispensary on 49,9 % ; increase of general detectability of stomatological pathology on 29,8 %; increase of early revealing of stomatological pathology on 27,4 %; decrease of general amount of complications on 19,2 %
Conclusion. Proceeding from that we can say that in modern conditions the level of risk of unfavorable outcomes of stomatological diseases is relatively high. Optimization of the content and increase of the volume of dispensary checkup have a favorable influence on the decrease of risk of unfavorable results of dental diseases. The effective diagnosis of the risk group and the emphasis on active early detection allow to improve the program of medical examination of patients with dental pathology

Молодежный инновационный вестник. 2023;12(S2):530-533
pages 530-533 views


Agarkova A.S.


The article reflects the subjective views of the respondents on the prospects for the development of telemedicine in Voronezh. Currently, the concept of telemedicine includes the development and practical application of technologies for remote medical care and information exchange, which are based on the use of information and telecommunication technologies.                                                                                                          Goal. To analyze awareness about electronic information and communication technologies, to assess the prospects for development in healthcare.                                          Methods. The method of interviewing was used, empirical, statistical, analytical methods were used in the course of the study. 120 respondents were interviewed, as a result of which the attitude to the use of digital technologies in medicine was clarified. Results. The majority of respondents believe that the introduction of digital technologies in medicine will have a positive impact on the quality of medical care, as well as increase its accessibility. At this stage of the development of telemedicine, its application in practice has a low prevalence. Conclusion. The study revealed low awareness, a positive assessment of its implementation, as well as the limitations of digital technologies in the practice of both the doctor and the patient  

Молодежный инновационный вестник. 2023;12(S2):473-474
pages 473-474 views


Kurdalin N.I.


The purpose of the study is to show what methods and methods of determining the sample size exist depending on the type of study being conducted.

In the course of our research, a number of methods have been developed and proposed, adapted for a doctor who does not have a special mathematical education. Examples of the use of these techniques for various types of medical research were considered and analyzed. Mathematical methods for determining the volume of samples for different types of medical research were used as materials and methods. We used the world experience of solving this problem. A number of foreign publications in highly rated world-class journals were studied and reviewed.

As the results of our study, calculations of the optimal sample size for diverse medical research were obtained. The methods that allow doctors to independently perform these mathematical calculations are proposed. For optimal "simplification" of the calculation process, the stages of solving this task were described. Specific examples are given for each specific case. In our study, the results of calculating sample volumes for various types of medical research were presented.

The sample size is one of the first steps in the development of the study; The calculation of the sample size is sensitive to errors, so it is recommended to consult with an experienced statistician when developing the study; When publishing the study, it is important to report in detail about the calculation of the sample size.

Молодежный инновационный вестник. 2023;12(S2):498-501
pages 498-501 views


Maslova V.A.


Relevance. The introduction of population projections in practical and scientific activities is a driving force for population analysis, and its usefulness is beyond doubt. By projecting over different time frames, it is directly possible to assess the prospects for the development of society and its components, including the development of the total urban and rural population. The analysis of demographic status is a basic factor in monitoring future developments.
Research objective. To consider and analyze the dynamics of development ,static dependencies of population size, relative to demographic projections and its variable components.
Materials and methods. The article applies the following methods: logical method, method of comparison, method of description and comparison.
Results. Depending on the demographic projection and the underlying data, population size is correlated with the level of projection.
Conclusion. Clearly, according to a high forecast, the population in 2025 will be 147,582.4 thousand. people - the entire population when in 2023 it was 147,281.9 thousand. The total population will increase by 300.5, which is a clear positive predictive sign.
Keywords: demography, demographic forecast, population, development strategy.

Молодежный инновационный вестник. 2023;12(S2):504-507
pages 504-507 views


Zaitsev A.I., Nematova M.E., Molodozhen E.G., Khachatrian V.A., Chaikovskaia E.A.


Relevance. It was suggested on the basis of the materials of one of the previously conducted own studies that the cognitive motivation is due not only to the desire to structure personal ideas and experience, but also to get an objective assessment of them, and the motivation is dedicated to the prevention of developmental disorders and diseases of the musculoskeletal system in children which refers to students of the natural science profile of the Kursk region [1].

The purpose is to study the awareness of students of the natural science profile of the Kursk region in relation to massage, therapeutic physical culture (TPC), physical and neuropsychic development of children.

Materials and methods. An online questionnaire was developed for comprehensive testing, the results were analyzed by calculation of relative values, grouped depending on the percentage of correct answers to the questions from the selected block and divided into 4 categories: "90-100%", "70-89%", "50-69%", "less than 50%." Summary data corresponding to values of 70% and above were interpreted as satisfactory awareness of the prevention of developmental disorders and pathologies of the musculoskeletal system in children.

Results. it was revealed that only 38 respondents (14.4%) received a satisfactory assessment when analyzing the distribution of test results by the total number of correct answers.  The majority of respondents id not reach the established testing threshold, thtare are 227 people (85.6%),

Conclusion. The organization of events in the format of open lectures and practical classes is proposed as a promising way to increase the awareness of students in the region on the prevention of developmental disorders and pathologies of the musculoskeletal system in children.

Молодежный инновационный вестник. 2023;12(S2):493-495
pages 493-495 views


Kostennikova K.M.


One of the key points in the implementation of the management of medical organizations is the assessment of the quality of conditions for the provision of medical services. This assessment shows the level of compliance of the actual conditions of medical care with those that would satisfy the needs of patients, which is important in the context of a patient-oriented line of work.
Goal. Improving the quality of services in a hospital-based medical organization, which can be achieved by developing a questionnaire for patients undergoing inpatient treatment in medical organizations of various profiles.
Methods. A questionnaire was developed, the questions of which were grouped into certain blocks, taking into account one or another criterion. After that, calculations were carried out to determine the final result.
Results. Conducting a survey among patients staying in a medical hospital revealed that 75% of respondents are satisfied with the quality of medical care conditions. In addition, comments were revealed in the organization of the work of the medical organization.
Conclusion. By collecting information from patients, certain areas were identified in the further work of health care organizers that will help improve the quality of medical services provided in order to solve existing problems.

Молодежный инновационный вестник. 2023;12(S2):495-498
pages 495-498 views


Akulshina S.A.


The development of preventive direction in medicine is closely related to the dispensary medical examination (DME) optimization. The last one not only effects the population's health but also has an economic effect. The relevance of the work is conditioned by the existence of some deficiencies in the process's organization, which leading to time and financial costs.

The aim of this work was to study the satisfaction of different age groups with DME, besides, to make the algorithm construction of the first stage's events, to search problems and ways to solve them. At first, the scientific works' researching and SERVQUAL methodology survey have been implemented. Then, according to the methodological recommendations for the new model of the medical organization, the IDEF0 and IDEF3 models have been drawn up.

The above-described methods confirmed the presence of various difficulties, including a work's disproportionation, long waiting time, building planning's defects. The main problems were structured, some ways of their solution were proposed.

The results of the survey proved the existence of certain problems, confirmed that the using of information and lean technologies helps to develop patient-centred healhtcare.

The active implementation of modern lean technologies therefore minimizes the number of disadvantages and the losses associated with them.

Молодежный инновационный вестник. 2023;12(S2):477-480
pages 477-480 views


Milovzorova A.I.


Relevance. The problem of hypogonadism, and especially postmenopausal disorders, is relevant all over the world. Much attention is paid to the relationship between hypogonadism and pathology of other organs and systems. The study of the correlation between the values of steroid hormones in the blood serum and the state of the oral mucosa, including periodontal, proved the effect of low estrogen concentrations on the development of destructive diseases of the COPD.
The purpose of the study: To establish the prevalence of diseases of the SOPR among people suffering from hypogonadism and to develop measures of the effectiveness of dental care provided to these patients.
Materials and methods. The article uses a comparative analysis of the methodological approach to the study of the prevalence of COPD diseases among people suffering from hypogonadism
Results. Steroid hormones, which include sex hormones, directly and indirectly affect cell proliferation and differentiation, immunological factors and reactions, expression of genes responsible for the production of cytokines and factors of cell death.
Conclusion. Prevention and treatment of COPD diseases in people with hypogonadism should be directed to the use of hormone replacement therapy in both male and female individuals. In postmenopausal women, this therapy leads to the restoration of the normal concentration of circulating estrogen, therefore, to a decrease in the development of inflammatory processes in the periodontal. Unfortunately, the practice of using HRT for the correction of postmenopausal changes in Russia is very limited due to the lack of awareness of the population about the relationship between the concentration of steroid hormones and diseases of the SOPR. Only 0.2% of Russian women of menopausal age use HRT. Men need to undergo a screening examination as a timely detection of age-related androgen deficiency. Undoubtedly, the main aspect of the prevention of chronic periodontitis is the individualization of medical care in the perspective of large-scale screening.

Молодежный инновационный вестник. 2023;12(S2):515-517
pages 515-517 views


Bilan A.A.


Literature data indicate that the pandemic of a new coronavirus infection is associated with an increase in the incidence of cerebral circulatory disorders. The purpose of the study is to consider the features of the epidemiological process of cerebral circulation disorders in the Kursk region and adjacent territories in 2020-2021. Methods: As data sources, state statistics on the primary incidence of a number of nosological units and the average annual population in the Russian Federation as a whole, the Central Federal District, the Kursk Region and the regions bordering it were used. The primary morbidity in general and separately for ischemic and hemorrhage-related processes is considered.Results: The data obtained indicate that the primary incidence of cerebral circulatory disorders in the Kursk region is significantly lower than the average for the country and the Federal District, as well as significantly lower in comparison with neighboring regions, while the difference in the indicators of the Kursk region in 2020 and 2021 is not statistically significant. Conclusions: Such results indicate that the Kursk region has adequately passed the pandemic-related problems with the incidence of cerebral circulation disorders, there is sufficient experience in the region on the problem and the need to analyze and disseminate this experience, including to other regions. 

Молодежный инновационный вестник. 2023;12(S2):480-483
pages 480-483 views


Huseynova S.A.


The article describes the services provided within the framework of medical and social assistance to the older generation. The problems of quality of these services and methods of their assessment are identified. An example of assessing the quality of social assistance services to the older generation is given on the example of one of the medical and social institutions of the stationary type. The role of conducting this assessment and the expediency of using survey methods are proved. The presented methodology made it possible to identify problems in the system under consideration and directions for their solution. In addition, when using it, it becomes possible to develop solutions to optimize interdepartmental interaction in the system of providing medical and social assistance to the older generation.
The purpose of the article is to identify the problems of the quality of medical and social assistance to the older generation in the organization of interdepartmental interaction.
Methodology used in the article: expert methods, survey methods, systematization and structuring of data, economic processing of the results obtained, forecasting and modeling of the situation.

Молодежный инновационный вестник. 2023;12(S2):491-493
pages 491-493 views


Manzhosov O.O.


Relevance: Health problems are most often found at the most inopportune moment. Many diseases are asymptomatic, and a person may not be aware of it. Therefore, regular medical examination, preventive medical examination (PMO) will allow you to identify various diseases at an early stage, when their treatment will be most effective. It is also known that to date, more than 21 million citizens of the Russian Federation have been ill with a new coronavirus infection (COVID – 19) and in addition to PMT and medical examination, the ill citizens undergo in-depth medical examination (UD). The medical examination is carried out within the framework of the program of state guarantees of free provision of medical care to citizens and the territorial program of state guarantees of free provision of medical care to citizens, both PMO and UD. The analysis of the conducted medical examination, PMO, and UD in a medical organization (MO) is a very important task for the rational use of resources and the formation of good health in the population, since it is a healthy person who forms a strong nation.
Objective: To analyze the generated coupons of outpatient patients for dispensarization, PM and UD in the medical information system "Quasar" of compulsory medical insurance and determine the implementation of regulatory indicators MO in these sections.
Materials and methods: Statistical accounting of medical examination, PMO and UD to identify problem areas and promising areas of development. Quantitative indicators of accounting for cases of outpatient visits by patients of the city polyclinic for the purpose of undergoing medical examination, PMO, UD for the 3rd quarter of 2022 will be subjected to comparative analysis. The end point of the study will be a comparison of the actual results of quantitative accounting with the normative planned indicators of the MO of the conducted medical examinations, PMO, UD of the population.
Results: The study took into account the statistical coupons of outpatient patients from the section of medical examination, PMO and UD of three randomly selected sections of one of the buildings, as well as the entire building of the Voronezh polyclinic. It turned out that district internists, at the selected sites, do not fulfill all sections of the regulatory plan of the Ministry of Health for medical examination and UD. The overall results for the sections of medical examination, PMO and UD of the building do not correspond to the regulatory plans of the organization.
Conclusion: In order to solve problems in the implementation of the regulatory plan, a more detailed analysis of the medical examination, PMO and UD should be carried out at all therapeutic areas of the polyclinic in order to form rational and correct management decisions, in order to optimize preventive measures and greater coverage of the population in accordance with the regulatory plans of the MO.

Молодежный инновационный вестник. 2023;12(S2):501-504
pages 501-504 views


Matasova J.A.


Relevance. According to the Ministry of Education, in 2021 the number of children's recreation camps decreased by almost 20% compared to the recent 2018 year (RIA Novosti, 05/18/2022) and this downward trend continues in the current 2022 year. In most of the existing children's camps, there are many problems of various social nature that directly affect the quality of recreation, as well as the health of children and adolescents due to the frequency of acute infectious diseases, problems with nutrition, medications, etc., which necessitates improving the quality and effectiveness of organizational measures.
The purpose of the study. To improve the activities of the medical center in the children's sanatorium camp on the basis of lean manufacturing technologies. In the work, 7 problems were noted in the organization of the process of therapeutic and preventive activities in the children's sanatorium camp: 1) insufficient measures to prevent the spread and infection of viral and skin diseases, 2) intersection of patient flows, 3) lack of navigation and safety signs, 4) lack of first aid skills among counselors, 5) the problem of sorting and storing medical records, 6) inconvenient location of reception points for nurses and the general layout of the medical center, 7) other problems, affecting the quality of medical services provided. The tasks of the work included the development and implementation of measures to eliminate these problems within the framework of the lean production methodology.
Materials and methods. The object of the study is a children's health complex of the sanatorium type "SHAKHTINSKY TEXTILE WORKER", located on the Black Sea coast in the Krasnodar Territory, Tuapse district, Olginka village. The subject of the study were patients aged 14 to 17 years, vacationers in the period from 01.07.2022 to 22.07.2022 and medical staff. 175 children and 11 medical workers took part in the survey. The purpose of the survey was the satisfaction of patients with the quality of medical care provided and the satisfaction of medical workers with working conditions. The questionnaire contained questions corresponding to the QUALITY OF SERVICE methodology. The methods of system analysis, methods of satisfaction assessment, methods and technologies of lean production, methods of improving the quality and efficiency of the medical center in the children's sanatorium camp were also used in the work.
Results. The ways to solve problems are based on methods and tools of lean manufacturing and Kaizen methodology: orientation to the contingent of vacationing children, universal quality control, the use of digital technologies, quality control circles and a system of proposals, autonomization, visualization, quality analysis (Ishikawa diagram), balancing.
Conclusions. Having analyzed the structure, functions and activities of the medical center of the children's sanatorium camp, problems were identified in the organization of the process of therapeutic and preventive activities, proposals were developed and partially implemented measures to improve the activities of the medical center based on lean manufacturing technologies.

Молодежный инновационный вестник. 2023;12(S2):507-511
pages 507-511 views


Geidarova E.D.


Cervical cancer remains an urgent problem today, which mainly affects the female reproductive system at the age of 20-40 years. In 2022, in most cases, cervical cancer is diagnosed at stages I and II. In 40% of women, the disease is detected at stages III and IV, while the five-year survival rate of patients with oncology stage I is 87%, with stage III - 43%, and with stage IV - 7% [1,2].

The most cost-effective method of cervical cancer prevention is screening and health education among the female population. Cervical cancer can be cured if diagnosed early and treated immediately. Women's awareness of HPV infection as a risk factor for cervical cancer is critical for participation in cervical screening programs [6].

Purpose of the study: Review of ways to increase public awareness of HPV infection and select the most effective ones.

Materials and methods

The study was carried out in several stages. In the first phase, ways were developed to raise women's awareness. The second stage was the implementation of the plan. At the third, a survey was conducted: data were recorded on age and the source from which women received information about the possibility of being screened.
The number of respondents was 44 (one person could select more than one item on the data collection questionnaire). The point of information materials was chosen by 17 (38.63%) women, from employees of the LCD - 30 (68%), from acquaintances - 9 (20.45%).
Of the women (303) screened, 54 (17.82%) were diagnosed with HPV. Most of the women who were diagnosed with HPV agreed to undergo a cytological examination.
According to the results of a cytological study of all women who visited the antenatal clinic, which is part of the VGKP N1 (306), 9 women had cervical dysplasia (2.9%), 31 had background processes (10.1%). There were no cases of cancer or suspected cancer during the study period.

The results of this study show that the best ways to increase public awareness of HPV, and ultimately, increase the detection of HPV infection, are the distribution of information materials and the active participation of facility staff in attracting women to undergo screening.

Молодежный инновационный вестник. 2023;12(S2):485-488
pages 485-488 views


Moliboga K.M.


Background. As early as 1980, according to the World Health Organization (WHO), there were about 150 million people suffering from diabetes mellitus. And in 2021, according to the International Federation of Diabetes, the number of patients was 536.6 million people, the number of deaths was 6.7 million. The total cost of diabetes treatment has reached $966 billion. 

Purpose. Problem-oriented analysis of data on the incidence of type 2 diabetes with a view to rational choice of the most successful approaches to reducing the number of complications and deaths of type 2 diabetes patients.

Materials and Methods.  The paper used the following methods: statistical, problem-logical, economic,  analysis of the literature, retrospective analysis.

Results. Diabetes Mellitus is a pressing problem today. The social significance of this disease is due to the significant economic damage to society. The greatest economic losses are represented by indirect costs (the country’s GDP loss due to incapacity for work). Within medical costs, the largest share is in the management of complications of diabetes mellitus. Early diagnosis of type 2 diabetes and competent monitoring of patients with already identified diabetes are needed to prevent disability and reduce complications. To this end, it would be purposeful to carry out such activities: the inclusion of primary care in the diagnosis of diabetes, the wide use of the questionnaire FINDRISK, the distribution and improvement of schools of diabetes, the problem of the test deficiencystreaks for glucosometers, development of the software product "Self-monitoring diary", development of a mobile system for monitoring blood sugar and application of telemedicine technologies as part of the federal electronic register EGISZ.

Conclusion: Diabetes mellitus is an urgent problem of modern medicine in terms of the costs of premature mortality and the development of complications. Late diagnosis of the disease, lack of self-control facilities are still unresolved health problems. The proposed measures will improve the timeliness and effectiveness of diabetes diagnosis, reduce the number of complications and, as a result, reduce material and economic losses.

Молодежный инновационный вестник. 2023;12(S2):517-520
pages 517-520 views


Gorushkina E.S., Eist N.V.


The relevance of the study is directly related to the demographic indicators given in the article, demonstrating an increase in the population over working age (which indicates the demographic aging of the population). An analysis of the number and ratio of medical and medical and social activities implemented within the framework of the Federal Project “Older Generation” of the national project “Demography” in the Voronezh Region as of 2022 is necessary to assess the level and quality of the implementation of state programs.
Using statistical and analytical research methods, it was found that both preventive and therapeutic activities aimed at supporting active longevity are being successfully carried out in the region.
A multi-level approach, organized and coordinated activities of each link contribute to the creation of a solid base for the future generation to continue their activities. Many years of active interaction between medical and social institutions creates the basis for the involvement of specialists from various fields of activity. The totality of activities carried out both within the framework of state funding and on a voluntary basis covers all spheres of life of the elderly, creates conditions for the realization of personal qualities, the formation of healthy longevity, taking into account the characteristics of the body.

Молодежный инновационный вестник. 2023;12(S2):488-490
pages 488-490 views


Akperova S.R., Dimitrova E.G., Babenko J.D.


Relevance. In Russia, about 31 million people suffer from diseases of the cardiovascular system. Moreover, every year there is a tendency for the manifestation of this pathology at an earlier age. If earlier the “usual” age for heart disease was 55-65 years, now there are more and more people under 40-50 years old suffering from cardiovascular diseases.

Purpose of the study. Based on the analysis of mortality rates of the population of the Voronezh region from diseases of the cardiovascular system and comparison of data with target indicators (up to 450 deaths per 100,000 population), determine the dynamics of mortality of the population of the Voronezh region from diseases of the cardiovascular system for 2019-2022.

Materials and methods. Using the statistics of the Department of Health of the Voronezh region, scientific literature, the results of the implementation of the national project "Health" in the territorial framework of the Voronezh region, to assess the state of the problem of cardiovascular diseases in the Voronezh region.

Results. The current state of the problem of cardiovascular diseases in the Voronezh region was studied. An analysis of the statistical data of the Department of Health of the VO based on the results of the regional project "Fight against cardiovascular diseases" was carried out. The patterns of decrease and temporary increase in mortality of the population for the period 2019-2022 were revealed.

Conclusion. According to the results of the study, a positive trend in reducing mortality from diseases of the cardiovascular system in the Voronezh region was revealed. Despite this, the pathology of the circulatory organs is still a hot topic for public health. An important aspect in preventing the development of these diseases is the prevention and early diagnosis of pathologies of the circulatory organs.

In addition, the possession of information on the incidence of the population in certain areas makes it possible to rationally optimize the resources of the urban healthcare system in order to increase the availability and quality of medical care for people suffering from pathologies of the cardiovascular system.

Keywords: cardiovascular disease, mortality, health care.

Молодежный инновационный вестник. 2023;12(S2):474-477
pages 474-477 views


Nasedkina M.Y., Anisimova T.A.


Clinical examination is a set of measures that includes a preventive medical examination and additional examination methods, carried out in order to assess the state of health (including determining the health group and the dispensary observation group) and carried out in relation to certain groups of the population in accordance with the legislation of the Russian Federation.
Goal of the work. To determine the level of awareness among students of medical universities and students of other universities about the possibilities of compulsory medical insurance and medical examination.
Materials and methods. To assess awareness, a survey was conducted among 104 students (84 medical students and 20 students from other universities), which included 19 questions.
Results. The key question aimed at awareness of medical examination revealed that all medical students surveyed know what medical examination is and 70% of students from other universities are also aware of this. It turned out that about 70% of the students passed medical examinations, among which the majority (76%) were satisfied with the organization, quantity and quality of the research.
Conclusion. The analysis of data from 104 students demonstrates that the topic of clinical examination and the possibilities of compulsory medical insurance is very relevant. The medical examination of the population is positioned by the Russian state as the most important tool of health policy.

Молодежный инновационный вестник. 2023;12(S2):520-522
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Peshkova A.A., Slusarev D.N.


Relevance. The development of urology as a clinical discipline, the emergence of new modern methods of diagnosis, treatment, and the level of training of specialists contributed to changing the structure of the organization of urological care to the population, aimed at reducing the main types of adverse outcomes of medical care, such as disability and mortality.
The aim of the study is to determine the currently available and relevant organizational aspects of the impact on the controlled causes of premature mortality and adverse outcomes of medical care.
Research materials. Patients of medical organizations of the Voronezh region of inpatient and outpatient type, medical documentation, analytical reports of Health Departments and the Ministry of Health of the Russian Federation, Official information sources on the problem.
Research methods. Historical analysis, collection of complaints and anamnestic data of patients, sociological (questionnaire), content analysis of medical documentation and official information sources, statistical.
The data of analytical reports of the Department of Health of the Voronezh Region for the period 2005-2010, 2011-2015, the Ministry of Health of the Russian Federation, official information sources on the problems of urological care were used [3].
Results. A program of organizational measures "three-level system of medical care" was developed and applied. This program included the following tools: a diagnostic system for risk groups, a clear system (protocols) for standardization of diagnostics, treatment, routing of patients, an adapted educational and methodological complex, determination of key performance indicators, an information and analytical support system.
Conclusion. At the moment, one of the most relevant organizational aspects of the impact on the controlled causes of premature mortality and adverse outcomes of medical care available for correction are: 1) the detectability of pathology, 2) the duration of the conservative stage of treatment, 3) operational activity, 4) timeliness and accessibility of medical care, 5) the use of minimally invasive and high-tech interventions, 6) the level of preparedness of specialists in applied aspects of medical care, 7) the level of medical literacy among the population, 8) standardization of medical care, 9) ergonomics and informatization of planning and control of organizational events

Молодежный инновационный вестник. 2023;12(S2):523-525
pages 523-525 views


Yan K.S., Nesterova A.V.


Relevance. Students are the most vulnerable group subject to negative external influences. Numerous factors have a shaping effect on the health status of this category of people, which emphasizes the obligation to determine the need for the implementation of health-saving technologies in the educational process.
Target. To compare health indicators among senior students of the pediatric faculty of the Voronezh State Medical University. N.N. Burdenko with the identification of the need to change motor and physical activity, and the possibility of implementing health-saving technologies on the basis of the Academic Health Center.
Materials and methods. We used the data of a survey conducted among senior students of the pediatric faculty of VSMU. N.N. Burdenko in the framework of the implementation of the program "Health saving of the able-bodied population" (for 2022-2023). 133 respondents took part in the survey. To calculate the indicators, we used the methods of processing statistical results in the standard package MS Office 2016 (Excel 2016) and on the statistical software package Statistica 10.0.
Results. Based on the results of the survey, the following data were obtained, showing low physical activity among senior students of the pediatric faculty. Only 14.3% of respondents showed high activity (they go to the gym at least 2 times a week), 45.1% and 40.6%, respectively, showed medium and low activity. In turn, the results of physical activity accounted for the vast majority in the range from 5 to 10 thousand steps per day (71.4%). A sufficiently high number of students declared their intention to increase physical activity, which, according to the results of the study, amounted to 77.5% of the number of respondents. Disappointing figures were shown in the response of respondents about visiting the Health Center "Academic" at the VSMU. N.N. Burdenko. Only 0.8% visit it regularly, and 91.7% did not visit it at all.
Conclusion. The implementation of health-saving technologies among students is one of the priority areas in modern conditions. High academic performance, quality of life directly depend on these events. Health Center "Academic" has a high potential for the development of health-saving technologies.

Молодежный инновационный вестник. 2023;12(S2):539-541
pages 539-541 views


Fedortsov A.А., Bulygin Y.O., Arkhipov V.Y.


Relevance: Ambulance, including emergency specialized medical care provided to citizens in conditions requiring urgent medical intervention, is one of the key links in the healthcare system of the Russian Federation. At the same time, the process of organizing the provision of EMS is extremely complicated due to the influence of many economic and non-economic factors, as well as a huge number of nosological forms, about which teams are called, which greatly complicates its standardization and development of regulatory documentation.

Оbjective: To analyze the structure of diseases, in connection with which the ambulance team is most often called in the city of Voronezh using the example of the work of the VSSMP.

Materials and Methods: The article is a retrospective study of data on patients who called the ambulance team of the Healthcare Institution of Higher Medical Education "VSSMP" taking into account the disease for which the call was made, gender, average age of patients, form of medical care, treatment options and the final status of the patient. When writing it, the hypothetical-deductive method, comparison, probabilistic-statistical methods, and generalization were used.

Results: The most common and statistically significant were 3 diseases out of 55 - G90, I11 and J06.9. No statistically significant differences were found among men and women in most nosologies, with the exception of patients with A04, B34.2, G90, I11, K35, K85, K86.1, M42. In most cases, age dependence is not observed or its detection is not possible, however, using the classification of age groups (according to WHO from 2015), some diseases can still be correlated with age: children and youth - A04, H60, J06.9, L50 ; young - G90, N92.1, O07; elderly and senile - I10, I11, I48, I67, N23. Assessing the compliance of the forms of medical care with certain nosologies, several inconsistencies with the Standards for the provision of medical care were revealed. For the healthcare system, repeated calls are of particular importance, since they give an additional and often unreasonable load on substations and all identified nosologies for this indicator stand out I11, J06.9 and I67. Also, special attention should be paid to diseases with which patients most often refuse hospitalization, even if there are indications for this, such as therapeutic (A04, G58.0, G90, I10, I64 and especially J06.9), as well as surgical ( N23, T26.6, S61, S62, K85).

Conclusion: The creation of a rational system for the provision of emergency, including emergency specialized, medical care is a real challenge for modern healthcare organizers, which requires taking into account a wide variety of factors, one of which is the nosological structure, which affects how often specialized care will be required, which determines routing (priority of emergency calls over emergency calls) of teams and the level of workload at the ambulance station.

Молодежный инновационный вестник. 2023;12(S2):535-538
pages 535-538 views


Potapova M.M., Konyaeva A.S.


Abstract. There is a relationship between the growth of pediatric oncology diseases and a number of factors: improving diagnostic capabilities, optimizing patient routing, etc. and the deterioration of the environmental situation in certain regions of Russia. Annually, such statistics are covered in the media. The goal is to analyze the incidence of leukemia in children, understand the causes of their development and outcomes, as well as assess the relationship between childhood cancer incidence and the environmental situation in the Russian Federation. The study was conducted on the basis of data on cancer incidence in the regions presented on the website 2019-2021, as well as specialized search engines (Сyberleninka, Elibrary). An increase in childhood cancer incidence is revealed, however, comparative studies of the influence of the environmental situation in a particular region have not been practically studied. The literature lists assumptions about the influence of the environment and the ecological situation on the epidemiology of oncological diseases in children. The data obtained can be used in scientific research to determine the rating of regions in terms of oncological diseases and evaluate the effectiveness of ongoing measures to eliminate the development of malignant neoplasms in children.

Молодежный инновационный вестник. 2023;12(S2):526-527
pages 526-527 views


Mezhuyeva V.Y., Novikova M.V.


Abstract. The article is devoted to the problem of trust in the modern healthcare system. The results of a sociological survey of junior and senior students, both medical and other universities, are analyzed.
Aim. To determine the attitude of modern youth to medical personnel and their own health, to identify the main problems associated with the availability of medical information and the priority of self-medication.
Materials and methods. A sociological survey on the Google-Form platform. Methods were used: analysis of the received information, work with statistical data. A total of 150 respondents were interviewed.
Results. According to the analyzed sample, most of the respondents are students of a medical university (44%) or another institute (40%). Based on the data obtained, it was revealed that only 18% of respondents seek medical help for health problems, 82% of respondents prefer to solve health problems on their own.
Conclusion. The problem of trust within the framework of available medical information is most acute and requires immediate solution.

Keywords: deontology, trust, sociological survey.

Молодежный инновационный вестник. 2023;12(S2):511-512
pages 511-512 views


Proskurin E.A.


Relevance: Urolithiasis remains one of the most common chronic non-communicable diseases, while there is no downward trend. Increasing morbidity, “rejuvenation” of the disease, and the persistence of high mortality determine the need to find new approaches to increase the effectiveness of treatment by increasing patient compliance.
Purpose of the study: To assess the impact of medical and social aspects on adherence to treatment of patients with urolithiasis who are in hospital.
Materials and Methods: We examined 100 patients with KSD in the acute stage (age from 20 to 60 years, mean - (42.0±1.2) years, men 59, women 41), who underwent inpatient treatment in the urology department.
Results: The lowest adherence to treatment was observed in patients with newly diagnosed KSD — the mean score was 2.0±1.1, and significantly differed (p<0.05) from patients with a longer duration of the disease, the mean score of adherence to treatment of which was 2.9±0.1. When analyzing adherence to treatment depending on gender, it was found that in men, high adherence to therapy is noted in 50.1% of cases, in women - in 73%. The influence of age, level of education of patients on adherence to treatment was not revealed. Among the married / married, the proportion of people with high adherence is 56.5%, among widowers / widows - 50%, while the lowest adherence to taking drugs was observed in people who have never been married (33.3%). When assessing the influence of the nature of work on adherence to the treatment of urolithiasis, it was revealed that among mental workers the proportion of people with high adherence is higher (70%) than among manual workers (50%), unemployed (40%) and pensioners (42.9 %).
Conclusion: It has been established that it was revealed that in patients with KSD there is an insufficient level of adherence to treatment. The best indicator of compliance between the doctor and the patient is observed in female patients who are married, who are knowledge workers, with a history of urolithiasis for more than 5 years. Increasing the adherence of patients with KSD to treatment is an urgent public health problem that largely determines the effectiveness of medical and social measures.

Молодежный инновационный вестник. 2023;12(S2):528-530
pages 528-530 views



Zatsepina E.A., Kazaryan D.G., Kotova A.L.


Relevance. Post- covid syndrome - consequences of COVID-19. According to Rospotrebnadzor, 20 % of people suffer from long-term symptoms. It should be noted that there are various disturbances in the body's systems from mood changes to heartbeat, from sleep to breathing, from the hormonal cycle to digestion. The treatment of post-COVID syndrome is also complicated by the difficulty of selecting drugs and an increase in their side effects. Medicinal plants do not have toxic properties and have a wide range of effects on various body systems.

Target. Having studied the main complications of coronavirus infection, consider the possibility of using some medicinal plants as an addition to the main treatment of post-COVID syndrome.

Methods. In this work, the general scientific method was used.

Results. Postcovid syndrome includes a violation of the functions of most organs and systems of the body. In addition, it can be aggravated by drugs used to treat acute coronavirus infection, so the use of medicinal plants can increase the effectiveness of treatment and improve the general condition of the body.

Conclusion. The use of medicinal plants as a general tonic can help avoid complications after suffering a coronavirus infection.